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Dnm1l Gene Detail
Summary
  • Symbol
    Dnm1l
  • Name
    dynamin 1-like
  • Synonyms
    6330417M19Rik, Dnmlp1, Drp1, python
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921256
    NCBI Gene: 74006
  • Gene Overview
    MyGene.info: DNM1L
Location & Maps
more
  • Sequence Map
    Chr16:16312235-16359030 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      46796 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DNM1L, dynamin 1-like
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DNM1L, dynamin 1-like
    Orthology source: HomoloGene
  • Synonyms
    DLP1, DRP1, DVLP, DYMPLE, EMPF, HDYNIV
  • Links
    NCBI Gene ID: 10059
    neXtProt AC: NX_O00429

  • Chr Location
    12p11.21; chr12:32679200-32745650 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human DNM1L associations

Human Disease Mouse Models
       Encephalopathy, Lethal, Due to Defective Mitochondrial and Peroxisomal Fission; EMPF   OMIM: 614388
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    70 phenotypes from 6 alleles in 8 genetic backgrounds
    4 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    28
  • Chemically induced (ENU)
    1
  • Gene trapped
    20
  • Targeted
    7
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit embryonic lethality at E11.5 with internal hemorrhage and small size. Mice heterozygous for an ENU induced allele have dilated cardiomyopathy and congestive heart failure, homozygous are embryonic lethal with posterior truncation at E11.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022789 Ensembl Gene Model | MGI Sequence Detail 46796 C57BL/6J ±  kb
transcript ENSMUST00000115749 Ensembl | MGI Sequence Detail 4068 Not Applicable  
polypeptide ENSMUSP00000111415 Ensembl | MGI Sequence Detail 716 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    134 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    cDNA 25

    Microarray probesets 9
Other
Accession IDs
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MGI:1195987, MGI:2146435
References
more
  • Summaries
    All 75
    Developmental Gene Expression 6
    Gene Ontology 16
    Phenotypes 22
  • Earliest
    J:45166 Kamimoto T, et al., Dymple, a novel dynamin-like high molecular weight GTPase lacking a proline-rich carboxyl-terminal domain in mammalian cells. J Biol Chem. 1998 Jan 9;273(2):1044-51
  • Latest
    J:226977 Moriya M, et al., Adult mice expressing a Braf Q241R mutation on an ICR/CD-1 background exhibit a cardio-facio-cutaneous syndrome phenotype. Hum Mol Genet. 2015 Dec 20;24(25):7349-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory