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Dnm1l Gene Detail
Summary
  • Symbol
    Dnm1l
  • Name
    dynamin 1-like
  • Synonyms
    6330417M19Rik, Dnmlp1, Drp1, python
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921256
    NCBI Gene: 74006
  • Gene Overview
    MyGene.info: DNM1L
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:16312230-16358959 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      46730 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 10.12 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DNM1L, dynamin 1 like
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DNM1L, dynamin 1 like
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DLP1, DRP1, DVLP, DYMPLE, EMPF, EMPF1, HDYNIV, OPA5
  • Links
    NCBI Gene ID: 10059
    neXtProt AC: NX_O00429
    UniProt: O00429

  • Chr Location
    12p11.21; chr12:32679200-32745650 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Dnm1l mouse models; 1 with human DNM1L associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    71 phenotypes from 6 alleles in 8 genetic backgrounds
    6 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality at E11.5 with internal hemorrhage and small size. Mice heterozygous for an ENU induced allele have dilated cardiomyopathy and congestive heart failure, homozygous are embryonic lethal with posterior truncation at E11.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022789 Ensembl Gene Model | MGI Sequence Detail 46730 C57BL/6J ±  kb
    transcript ENSMUST00000230980 Ensembl | MGI Sequence Detail 2151 Not Applicable  
    polypeptide ENSMUSP00000155155 Ensembl | MGI Sequence Detail 716 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      134 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 26

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1195987, MGI:2146435
    References
    more
    • Summaries
      All 110
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 19
      Phenotypes 32
    • Earliest
      J:45166 Kamimoto T, et al., Dymple, a novel dynamin-like high molecular weight GTPase lacking a proline-rich carboxyl-terminal domain in mammalian cells. J Biol Chem. 1998 Jan 9;273(2):1044-51
    • Latest
      J:260505 Schmitt K, et al., Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics. Cell Metab. 2018 Mar 6;27(3):657-666.e5

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory