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Dnm1l
Gene Detail
Symbol

Name
ID
Dnm1l
dynamin 1-like
MGI:1921256
Synonyms
6330417M19Rik, Dnmlp1, Drp1, python
Feature Type
protein coding gene
Genetic Map
Chromosome 16
10.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:16312235-16359030 bp, - strand
From Ensembl annotation of GRCm38

  46796 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6384  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: dynamin-related, VPS1
Gene Tree: Dnm1l

Human
homologs
Human Homolog DNM1L, dynamin 1-like
NCBI Gene ID 10059
neXtProt AC  NX_O00429
Human Synonyms  DLP1, DRP1, DVLP, DYMPLE, EMPF, HDYNIV
Human Chr (Location)  12p11.21; chr12:32679200-32745650 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DNM1L
Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Chemically induced (ENU)(1) Gene trapped(20) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit embryonic lethality at E11.5 with internal hemorrhage and small size. Mice heterozygous for an ENU induced allele have dilated cardiomyopathy and congestive heart failure, homozygous are embryonic lethal with posterior truncation at E11.5.
 
Phenotype Images(1)
Interactions
Dnm1l interacts with 321 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (56 annotations)
Process dynamin polymerization involved in mitochondrial fission, endocytosis, ...
Component cell junction, coated pit, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) cDNA(25)
Microarray probesets(9)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022789 Ensembl Gene Model | MGI Sequence Detail 46796 C57BL/6J ±  kb
transcript ENSMUST00000115749 Ensembl | MGI Sequence Detail 4068 Not Applicable 
polypeptide ENSMUSP00000111415 Ensembl | MGI Sequence Detail 716 Not Applicable 

For the selected sequences
All sequences(101) RefSeq(33) UniProt(5)
Polymorphisms
SNPs within 2kb(134 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022812 Dynamin
InterPro IPR000375 Dynamin central domain
InterPro IPR001401 Dynamin, GTPase domain
InterPro IPR003130 Dynamin GTPase effector
InterPro IPR019762 Dynamin, GTPase region, conserved site
InterPro IPR020850 GTPase effector domain, GED
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000006602 dynamin-1-like protein
References
(Earliest) J:45166 Kamimoto T, et al., Dymple, a novel dynamin-like high molecular weight GTPase lacking a proline-rich carboxyl-terminal domain in mammalian cells. J Biol Chem. 1998 Jan 9;273(2):1044-51
(Latest) J:208253 Richter V, et al., Structural and functional analysis of MiD51, a dynamin receptor required for mitochondrial fission. J Cell Biol. 2014 Feb 17;204(4):477-86
All references(66)
Other
accession IDs
MGI:1195987, MGI:2146435

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory