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Irak3 Gene Detail
Summary
  • Symbol
    Irak3
  • Name
    interleukin-1 receptor-associated kinase 3
  • Synonyms
    4833428C18Rik, IRAK-M
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921164
    NCBI Gene: 73914
  • Gene Overview
    MyGene.info: IRAK3
Location & Maps
more
  • Sequence Map
    Chr10:120141648-120202130 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      60483 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 67.94 cM, cytoband D2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    IRAK3, interleukin 1 receptor associated kinase 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    IRAK3, interleukin 1 receptor associated kinase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ASRT5, IRAKM
  • Links
    NCBI Gene ID: 11213
    neXtProt AC: NX_Q9Y616
    UniProt: Q9Y616

  • Chr Location
    12q14.3; chr12:66189198-66254622 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    2 with Irak3 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display abnormal inflammatory responses to bacterial infections and loose bone mass with age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    54
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    23
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034096 VEGA Gene Model | MGI Sequence Detail 60483 C57BL/6J ±  kb
transcript OTTMUST00000086213 VEGA | MGI Sequence Detail 3097 Not Applicable  
polypeptide OTTMUSP00000046651 VEGA | MGI Sequence Detail 609 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    448 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    cDNA 23

    Microarray probesets 4
Other
Accession IDs
less
MGI:2143647
References
more
  • Summaries
    All 65
    Diseases 2
    Gene Ontology 9
    Phenotypes 30
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:231897 Kesselring R, et al., IRAK-M Expression in Tumor Cells Supports Colorectal Cancer Progression through Reduction of Antimicrobial Defense and Stabilization of STAT3. Cancer Cell. 2016 May 9;29(5):684-96
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/20/2017
MGI 6.10 		The Jackson Laboratory