About   Help   FAQ
Irak3
Gene Detail
Symbol

Name
ID
Irak3
interleukin-1 receptor-associated kinase 3
MGI:1921164
Synonyms
4833428C18Rik, IRAK-M
Feature Type
protein coding gene
Genetic Map
Chromosome 10
67.94 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:120141648-120202130 bp, - strand
From VEGA annotation of GRCm38

  60483 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36215  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Irak3

Human
homologs
Human Homolog IRAK3, interleukin-1 receptor-associated kinase 3
NCBI Gene ID 11213
neXtProt AC  NX_Q9Y616
Human Synonyms  ASRT5, IRAKM
Human Chr (Location)  12q14.3; chr12:66189198-66254622 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human IRAK3
Mutations,
alleles, and
phenotypes
All mutations/alleles(78) : Gene trapped(75) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display abnormal inflammatory responses to bacterial infections and loose bone mass with age.
 
Human Diseases Modeled Using Mouse Irak3 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Irak3 interacts with 209 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (55 annotations)
Process apoptotic process, cytokine-mediated signaling pathway, ...
Component cytoplasm, interleukin-1 receptor complex, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(23)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000034096 (Evidence)
Ensembl Gene ModelENSMUSG00000020227 (Evidence)
Entrez Gene73914 (Evidence)
UniGene146194
DFCITC1704302, TC1581461
DoTSDT.55143549, DT.528664, DT.101723531
NIA Mouse Gene IndexU032277
EC2.7.11.1
Consensus CDS ProjectCCDS24204.1
International Mouse Knockout Project StatusIrak3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034096 VEGA Gene Model | MGI Sequence Detail 60483 C57BL/6J ±  kb
transcript OTTMUST00000086213 VEGA | MGI Sequence Detail 3097 Not Applicable 
polypeptide OTTMUSP00000046651 VEGA | MGI Sequence Detail 609 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(9) UniProt(7)
Polymorphisms
SNPs within 2kb(453 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
Protein Ontology PR:000001784 interleukin-1 receptor-associated kinase 3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:206904 Zhou H, et al., IRAK-M mediates Toll-like receptor/IL-1R-induced NFkappaB activation and cytokine production. EMBO J. 2013 Feb 20;32(4):583-96
All references(59)
Disease annotation references (1)
Other
accession IDs
MGI:2143647

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/18/2014
MGI 5.20
The Jackson Laboratory