Irak3 Gene Detail

Summary

• Symbol
  Irak3
• Name
  interleukin-1 receptor-associated kinase 3
• Synonyms
  4833428C18Rik, IRAK-M

• Feature Type
  protein coding gene
• IDs
  MGI:1921164
  NCBI Gene: 73914
• Gene Overview
  MyGene.info: IRAK3

Location & Maps

• Sequence Map
  Chr10:120141648-120202130 bp, - strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    60483 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 10, 67.94 cM, cytoband D2
• Mapping Data
  3 experiments

Homology

• Human Ortholog
  IRAK3, interleukin 1 receptor associated kinase 3

• Vertebrate Orthologs
  8

• Human Ortholog
  IRAK3, interleukin 1 receptor associated kinase 3
  Orthology source: HomoloGene, HGNC
• Synonyms
  ASRT5, IRAKM
• Links
  HGNC:17020

  NCBI Gene ID: 11213

  neXtProt AC: NX_Q9Y616

  
  
• Chr Location
  12q14.3; chr12:66189198-66254622 (+)  GRCh38.p2

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• HomoloGene
  Vertebrate Homology Class 36215
  1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 zebrafish
  
• HCOP
  human homology predictions: IRAK3
• Gene Tree
  Irak3
  

Human Diseases

• Diseases
  1 with Irak3 mouse models; 1 with human IRAK3 associations

Human Disease

Mouse Models

Osteoporosis   OMIM: 166710

View 1 model

Mouse Models

Human Disease Modeled: Osteoporosis

Allelic Composition	Genetic Background	Reference	Phenotypes
Irak3tm1Flv/Irak3tm1Flv	involves: 129S1/Sv * C57BL/6	J:98035	View

Asthma-Related Traits, Susceptibility to, 5   OMIM: 611064

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  20 phenotypes from 1 allele in 1 genetic background
  1 images
  30 phenotype references
  

• All Mutations and Alleles
  79
• Chemically induced (other)
  1
• Gene trapped
  75
• Targeted
  3
• Genomic Mutations
  1 involving Irak3
• Incidental Mutations
  Mutagenetix , APF

Mice homozygous for disruptions in this gene display abnormal inflammatory responses to bacterial infections and loose bone mass with age.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  54
• GO References
  9

• External Resources
  FuncBase

Expression

• cDNA Data
  23

• Other Mouse Links
  Allen Institute
  GEO
• Other Vertebrate Links
  ZFIN irak3

Interactions

• Irak3 interacts with 209 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

Sequences &
Gene Models

• All Sequences
  44
• RefSeq
  7
• UniProt
  4
• CCDS
  CCDS24204.1
• UniGene
  146194

• VEGA
  OTTMUSG00000034096 (Evidence)
• Ensembl
  ENSMUSG00000020227 (Evidence)
• NCBI Gene
  73914

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000034096	VEGA Gene Model | MGI Sequence Detail	60483	C57BL/6J
transcript	OTTMUST00000086213	VEGA | MGI Sequence Detail	3097	Not Applicable
polypeptide	OTTMUSP00000046651	VEGA | MGI Sequence Detail	609	Not Applicable

Polymorphisms

• SNPs within 2kb
  448 from dbSNP Build 142

Protein
Information

• UniProt
  4 Sequences
• Protein Ontology
  PR:000001784 interleukin-1 receptor-associated kinase 3
• EC
  2.7.11.1
• InterPro Domains
  IPR000488 Death domain
  IPR011029 Death-like domain
  IPR033610 Interleukin-1 receptor-associated kinase 3
  IPR000719 Protein kinase domain
  IPR011009 Protein kinase-like domain

Molecular
Reagents

• All nucleic 23

  cDNA 23

  
  

  Microarray probesets 4

Other
Accession IDs

MGI:2143647

References

• Summaries
  All 59

  Diseases 1

  Gene Ontology 9

  Phenotypes 30
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:231897 Kesselring R, et al., IRAK-M Expression in Tumor Cells Supports Colorectal Cancer Progression through Reduction of Antimicrobial Defense and Stabilization of STAT3. Cancer Cell. 2016 May 9;29(5):684-96