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Irak3
Gene Detail
Symbol

Name
ID
Irak3
interleukin-1 receptor-associated kinase 3
MGI:1921164
Synonyms
4833428C18Rik, IRAK-M
Feature Type
protein coding gene
Genetic Map
Chromosome 10
67.94 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:120141648-120202130 bp, - strand
From VEGA annotation of GRCm38

  60483 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36215  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

HCOP human homology predictions: IRAK3
Gene Tree: Irak3

Human
homologs
IRAK3, interleukin-1 receptor-associated kinase 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 11213
neXtProt AC: NX_Q9Y616

Human Synonyms: ASRT5, IRAKM

Human Chr (Location): 12q14.3; chr12:66189198-66254622 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human IRAK3

Mutations,
alleles, and
phenotypes
All mutations/alleles(78) : Gene trapped(75) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display abnormal inflammatory responses to bacterial infections and loose bone mass with age.
 
Human Diseases Modeled in Mice Using Irak3 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Irak3 interacts with 209 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (57 annotations)
Process apoptotic process, cytokine-mediated signaling pathway, ...
Component cytoplasm, intracellular, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN irak3    NEW 
Molecular
reagents
All nucleic(23) cDNA(23)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000034096 (Evidence)
Ensembl Gene Model ENSMUSG00000020227 (Evidence)
Entrez Gene 73914 (Evidence)
UniGene 146194
DFCI TC1581461, TC1704302
DoTS DT.101723531, DT.528664, DT.55143549
NIA Mouse Gene Index U032277
EC 2.7.11.1
Consensus CDS Project CCDS24204.1
International Mouse Phenotyping Consortium Status Irak3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034096 VEGA Gene Model | MGI Sequence Detail 60483 C57BL/6J ±  kb
transcript OTTMUST00000086213 VEGA | MGI Sequence Detail 3097 Not Applicable 
polypeptide OTTMUSP00000046651 VEGA | MGI Sequence Detail 609 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(7) UniProt(4)
Polymorphisms
SNPs within 2kb(453 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
Protein Ontology PR:000001784 interleukin-1 receptor-associated kinase 3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:216920 Maitra U, et al., Molecular mechanisms responsible for the reduced expression of cholesterol transporters from macrophages by low-dose endotoxin. Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):24-33
All references(59)
Disease annotation references (1)
Other
accession IDs
MGI:2143647

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory