Irak3
Gene Detail

Symbol

Name
ID

Irak3
interleukin-1 receptor-associated kinase 3
MGI:1921164

Synonyms

4833428C18Rik, IRAK-M

Feature Type

protein coding gene

Genetic Map

Chromosome 10
67.94 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr10:120141648-120202130 bp, - strand From VEGA annotation of GRCm38   60483 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:36215  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Irak3

Human
homologs

Human Homolog		IRAK3, interleukin-1 receptor-associated kinase 3
NCBI Gene ID		11213
neXtProt AC		NX_Q9Y616
Human Synonyms		ASRT5, IRAKM
Human Chr (Location)		12q14.3; chr12:66189198-66254622 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human IRAK3

Mutations,
alleles, and
phenotypes

All mutations/alleles(78) : Gene trapped(75) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for disruptions in this gene display abnormal inflammatory responses to bacterial infections and loose bone mass with age.

 
Human Diseases Modeled in Mice Using Irak3 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(1)

Interactions

Irak3 interacts with 209 markers (Mir9-1, Mir9-2, Mir9-3, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (55 annotations)

Process	apoptotic process, cytokine-mediated signaling pathway, ...
Component	cytoplasm, interleukin-1 receptor complex, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(23) cDNA(23)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000034096 (Evidence)
Ensembl Gene Model	ENSMUSG00000020227 (Evidence)
Entrez Gene	73914 (Evidence)
UniGene	146194
DFCI	TC1581461, TC1704302
DoTS	DT.55143549, DT.528664, DT.101723531
NIA Mouse Gene Index	U032277
EC	2.7.11.1
Consensus CDS Project	CCDS24204.1
International Mouse Knockout Project Status	Irak3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034096	VEGA Gene Model | MGI Sequence Detail	60483	C57BL/6J
transcript	OTTMUST00000086213	VEGA | MGI Sequence Detail	3097	Not Applicable
polypeptide	OTTMUSP00000046651	VEGA | MGI Sequence Detail	609	Not Applicable

All sequences(55) RefSeq(9) UniProt(7)

Polymorphisms

SNPs within 2kb(453 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR000488	Death domain
InterPro	IPR011029	Death-like domain
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
Protein Ontology	PR:000001784	interleukin-1 receptor-associated kinase 3

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:206904 Zhou H, et al., IRAK-M mediates Toll-like receptor/IL-1R-induced NFkappaB activation and cytokine production. EMBO J. 2013 Feb 20;32(4):583-96
All references(59)
Disease annotation references (1)

Other
accession IDs

MGI:2143647