Phenotypes Associated with This Genotype

Genotype
MGI:3584247

• Allelic Composition: Irak3^tm1Flv/Irak3^tm1Flv
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Small size and reduced total bone mineral density in Irak3^tm1Flv/Irak3^tm1Flv mice

immune system

abnormal immune system morphology ( J:78189 )

increased neutrophil cell number ( J:78189 )

• increased numbers of polymorphonuclear cells found in Peyer's patches

increased osteoclast cell number ( J:98035 )

• increased numbers of osteoclasts per unit area of bone surface

abnormal Peyer's patch morphology ( J:78189 )

• shows hemorrhaging

enlarged Peyer's patches ( J:78189 )

• grossly enlarged after infection with gram negative bacteria

increased interleukin-12b secretion ( J:78189 )

• increased amounts of Il12p40 produced by macrophage when challenged by either gram negative or gram positive bacteria

increased interleukin-6 secretion ( J:78189 )

• increased amounts produced by macrophage when challenged by either gram negative or gram positive bacteria

increased tumor necrosis factor secretion ( J:78189 )

• increased amounts produced by macrophage when challenged by gram negative bacteria

abnormal inflammatory response ( J:78189 )

increased susceptibility to endotoxin shock ( J:78189 )

• decreased tolerance to endotoxin

abnormal innate immunity ( J:78189 )

• enhanced innate immunity

• bacterial load not greatly increased in spleens of mice with bacterial infections

abnormal osteoclast physiology ( J:98035 )

• bone marrow macrophage have a reduced proliferation rate but fuse more rapidly

• osteoclasts are generated more rapidly and have more prolonged life spans

skeleton

increased osteoclast cell number ( J:98035 )

• increased numbers of osteoclasts per unit area of bone surface

abnormal osteoclast physiology ( J:98035 )

• bone marrow macrophage have a reduced proliferation rate but fuse more rapidly

• osteoclasts are generated more rapidly and have more prolonged life spans

decreased diameter of femur ( J:98035 )

• decreased diameter of the femur in both sexes

kyphosis ( J:98035 )

• develops by 4 months of age

abnormal compact bone morphology ( J:98035 )

• lower cortical bone content at 4 months of age in the femur

decreased compact bone thickness ( J:98035 )

• cortical thickness of the femur reduced in males

increased osteoblast cell number ( J:98035 )

• increased numbers of osteoblasts seen in males

abnormal trabecular bone morphology ( J:98035 )

• trabecular bone content at epiphyses reduced

decreased trabecular bone volume ( J:98035 )

• 60% reduction in trabecular bone volume

growth/size/body

decreased body size ( J:98035 )

• by 4 months of age

hematopoietic system

increased neutrophil cell number ( J:78189 )

• increased numbers of polymorphonuclear cells found in Peyer's patches

increased osteoclast cell number ( J:98035 )

• increased numbers of osteoclasts per unit area of bone surface

abnormal osteoclast physiology ( J:98035 )

• bone marrow macrophage have a reduced proliferation rate but fuse more rapidly

• osteoclasts are generated more rapidly and have more prolonged life spans

limbs/digits/tail

decreased diameter of femur ( J:98035 )

• decreased diameter of the femur in both sexes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
osteoporosis		DOID:11476	OMIM:166710	J:98035