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Ttc7 Gene Detail
Summary
  • Symbol
    Ttc7
  • Name
    tetratricopeptide repeat domain 7
  • Synonyms
    1110035E02Rik, 1700007L07Rik, fsn, hea
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920999
    NCBI Gene: 225049
  • Gene Overview
    MyGene.info: TTC7A
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:87282886-87381769 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 57.12 cM, cytoband E4
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    537 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920999
protein coding gene Chr17:87282687-87381770 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024101
protein coding gene Chr17:90660397-90767655 (+)
A/J MGP_AJ_G0024060
protein coding gene Chr17:87743079-87842930 (+)
AKR/J MGP_AKRJ_G0024029
protein coding gene Chr17:89217578-89319753 (+)
BALB/cJ MGP_BALBcJ_G0024061
protein coding gene Chr17:87592346-87693803 (+)
C3H/HeJ MGP_C3HHeJ_G0023826
protein coding gene Chr17:90087503-90191910 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024506
protein coding gene Chr17:93785791-93893531 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021945
protein coding gene Chr17:82882714-82984528 (+)
CAST/EiJ MGP_CASTEiJ_G0023305
protein coding gene Chr17:90913179-91018836 (+)
CBA/J MGP_CBAJ_G0023800
protein coding gene Chr17:97738733-97839580 (+)
DBA/2J MGP_DBA2J_G0023928
protein coding gene Chr17:86178564-86277825 (+)
FVB/NJ MGP_FVBNJ_G0023894
protein coding gene Chr17:85690071-85790923 (+)
LP/J MGP_LPJ_G0024012
protein coding gene Chr17:91444729-91552134 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023922
protein coding gene Chr17:97613753-97713756 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024551
protein coding gene Chr17:89736521-89836684 (+)
PWK/PhJ MGP_PWKPhJ_G0023050
protein coding gene Chr17:85818348-85941597 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022861
protein coding gene Chr17:86479491-86580263 (+)
WSB/EiJ MGP_WSBEiJ_G0023371
protein coding gene Chr17:90573427-90679386 (+)



Homology
more
  • Human Ortholog
    TTC7A, tetratricopeptide repeat domain 7A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TTC7A, tetratricopeptide repeat domain 7A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GIDID, MINAT, TTC7
  • Links
    NCBI Gene ID: 57217
    neXtProt AC: NX_Q9ULT0
    UniProt: Q9ULT0

  • Chr Location
    2p21; chr2:46915931-47076136 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 12515
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TTC7A
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Ttc7 mouse models; 1 with human TTC7A associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    82 phenotypes from 3 alleles in 10 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous mutation exhibit reduced growth, sparse hair, thickened, scaly skin, increased numbers of splenic B cells, macrophages, and erythroid cells, elevated IgE, glomerulonephritis, and forestomach papillomas.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036918 Ensembl Gene Model | MGI Sequence Detail 98884 C57BL/6J ±  kb
transcript ENSMUST00000041110 Ensembl | MGI Sequence Detail 4614 Not Applicable  
polypeptide ENSMUSP00000040771 Ensembl | MGI Sequence Detail 858 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 71
    cDNA 71

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10690, MGD-MRK-9877, MGI:1922718, MGI:95584, MGI:96068
References
more
  • Summaries
    All 54
    Diseases 1
    Gene Ontology 5
    Phenotypes 29
  • Earliest
    J:7515 Shimizu K, et al., Hereditary erythroblastic anaemia in the laboratory mouse. Lab Anim. 1983 Jul;17(3):198-202
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory