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Ttc7
Gene Detail
Symbol

Name
ID
Ttc7
tetratricopeptide repeat domain 7
MGI:1920999
Synonyms
1110035E02Rik, 1700007L07Rik, fsn, hea
Feature Type
protein coding gene
Genetic Map
Chromosome 17
57.12 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr17:87282886-87381769 bp, + strand
From VEGA annotation of GRCm38

  98884 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12515  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TTC7A
Gene Tree: Ttc7

Human
homologs
TTC7A, tetratricopeptide repeat domain 7A
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 57217
neXtProt AC: NX_Q9ULT0

Human Synonyms: GIDID, MINAT, TTC7

Human Chr (Location): 2p21; chr2:46916129-47076136 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TTC7A

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Spontaneous(3) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a spontaneous mutation exhibit reduced growth, sparse hair, thickened, scaly skin, increased numbers of splenic B cells, macrophages, and erythroid cells, elevated IgE, glomerulonephritis, and forestomach papillomas.
 
Interactions
Ttc7 interacts with 329 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process cellular iron ion homeostasis, hemopoiesis
Component cell
External Resources: FuncBase
Expression
cDNA source data(69)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN ttc7a    NEW 
Molecular
reagents
All nucleic(70) cDNA(70)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000028525 (Evidence)
Ensembl Gene Model ENSMUSG00000036918 (Evidence)
Entrez Gene 225049 (Evidence)
UniGene 77396
DFCI TC1578451, TC1624268, TC1658761, TC1702346, TC1733454
DoTS DT.101353130, DT.40174797, DT.87072388, DT.91421482, DT.91577881, DT.97337987
Consensus CDS Project CCDS29016.1
International Mouse Phenotyping Consortium Status Ttc7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028525 VEGA Gene Model | MGI Sequence Detail 98884 C57BL/6J ±  kb
transcript OTTMUST00000070689 VEGA | MGI Sequence Detail 4614 Not Applicable 
polypeptide OTTMUSP00000036065 VEGA | MGI Sequence Detail 858 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(8) UniProt(8)
Polymorphisms
SNPs within 2kb(537 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR026900 Tetratricopeptide repeat protein 7
InterPro IPR001440 Tetratricopeptide TPR-1
InterPro IPR013105 Tetratricopeptide TPR2
Protein Ontology PR:000032808 tetratricopeptide repeat protein 7A
References
(Earliest) J:7515 Shimizu K, et al., Hereditary erythroblastic anaemia in the laboratory mouse. Lab Anim. 1983 Jul;17(3):198-202
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(51)
Other
accession IDs
MGD-MRK-10690, MGD-MRK-9877, MGI:1922718, MGI:95584, MGI:96068

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory