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Symbol
Name
ID

Ttc7
tetratricopeptide repeat domain 7
MGI:1920999

Phenotype annotations related to integument

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Psoriasiform dermatitis
Disease(s) Associated with TTC7A	Psoriasiform dermatitis
multiple intestinal atresia

Mouse Phenotypes

integument phenotype

epidermal necrosis

increased dendritic epidermal T cell number

abnormal coat/ hair morphology

abnormal coat/hair pigmentation

alopecia

sparse hair

abnormal hair shaft morphology

abnormal hair cuticle

abnormal nail morphology

deformed nails

abnormal dermal layer morphology

mixed cellular infiltration to dermis

abnormal epidermal layer morphology

hyperkeratosis

orthokeratosis

parakeratosis

abnormal epidermis stratum granulosum morphology

abnormal keratohyalin granule morphology

hypergranulosis

acanthosis

abnormal keratinocyte morphology

epidermal hyperplasia

thick epidermis

flaky skin

pallor

scaly skin

skin lesions

abnormal skin pigmentation

abnormal tail pigmentation

abnormal skin condition

Availability

Mouse Genotype

Ttc7^fsn-Jic/Ttc7^fsn-Jic

*

Ttc7^fsn/Ttc7^fsn

!

Ttc7^hea/Ttc7^hea

Ttc7^em1(IMPC)J/Ttc7⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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