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Mark4 Gene Detail
Summary
  • Symbol
    Mark4
  • Name
    MAP/microtubule affinity regulating kinase 4
  • Synonyms
    2410090P21Rik, Markl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920955
    NCBI Gene: 232944
  • Gene Overview
    MyGene.info: MARK4
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:19425102-19458797 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 9.78 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    295 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920955
protein coding gene Chr7:19424775-19458821 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031778
protein coding gene Chr7:17424537-17462219 (-)
A/J MGP_AJ_G0031754
protein coding gene Chr7:17071824-17103975 (-)
AKR/J MGP_AKRJ_G0031680
protein coding gene Chr7:17544179-17576895 (-)
BALB/cJ MGP_BALBcJ_G0031759
protein coding gene Chr7:17272063-17307975 (-)
C3H/HeJ MGP_C3HHeJ_G0031481
protein coding gene Chr7:17803832-17839347 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032225
protein coding gene Chr7:18299836-18338891 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029291
protein coding gene Chr7:18716823-18752553 (-)
CAST/EiJ MGP_CASTEiJ_G0030825
protein coding gene Chr7:14225778-14264611 (-)
CBA/J MGP_CBAJ_G0031443
protein coding gene Chr7:18958169-18990959 (-)
DBA/2J MGP_DBA2J_G0031598
protein coding gene Chr7:17013234-17046742 (-)
FVB/NJ MGP_FVBNJ_G0031550
protein coding gene Chr7:16874947-16909818 (-)
LP/J MGP_LPJ_G0031681
protein coding gene Chr7:17747797-17789664 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031586
protein coding gene Chr7:18817074-18851324 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032253
protein coding gene Chr7:17140846-17176061 (-)
PWK/PhJ MGP_PWKPhJ_G0030548
protein coding gene Chr7:14107983-14140477 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030375
protein coding gene Chr7:11853645-11889999 (-)
WSB/EiJ MGP_WSBEiJ_G0030924
protein coding gene Chr7:17367883-17401978 (-)



Homology
more
  • Human Ortholog
    MARK4, microtubule affinity regulating kinase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MARK4, microtubule affinity regulating kinase 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MARK4L, MARK4S, MARKL1, MARKL1L, PAR-1D
  • Links
    NCBI Gene ID: 57787
    neXtProt AC: NX_Q96L34
    UniProt: Q96L34

  • Chr Location
    19q13.32; chr19:45251258-45305283 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit insulin hypersensitivity and resistance to diet-induced obersity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 232944 NCBI Gene Model | MGI Sequence Detail 33696 C57BL/6J ±  kb
transcript NM_172279 RefSeq | MGI Sequence Detail 2259 Swiss Webster  
polypeptide Q8CIP4 UniProt | EBI | MGI Sequence Detail 752 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 8
Other
Accession IDs
less
MGI:2142337
References
more
  • Summaries
    All 35
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:249560 Li X, et al., MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism. Nat Commun. 2017 Jun 28;8:15986

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory