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Mark4
Gene Detail
 Symbol
Name
ID
Mark4
MAP/microtubule affinity-regulating kinase 4
MGI:1920955
Synonyms 2410090P21Rik, Markl1
Feature Type protein coding gene
Genetic Map
Chromosome 7
9.78 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:19426075-19458494 bp, - strand
From NCBI annotation of GRCm38

  32420 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:57146  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Gene Tree: Mark4

Human
homologs
Human Homolog MARK4, MAP/microtubule affinity-regulating kinase 4
NCBI Gene ID 57787
neXtProt AC  NX_Q96L34
Human Synonyms  MARK4L, MARK4S, MARKL1, MARKL1L, PAR-1D
Human Chr (Location)  19q13.3; chr19:45251258-45305283 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele exhibit insulin hypersensitivity and resistance to diet-induced obersity.
 
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process microtubule cytoskeleton organization, nervous system development, ...
Component centrosome, microtubule cytoskeleton, ...
Function ATP binding, gamma-tubulin binding, ...
External Resources: FuncBase
Expression
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(7) Other(1)
Microarray probesets(8)
Other database
links
Ensembl Gene ModelENSMUSG00000030397 (Evidence)
Entrez Gene232944 (Evidence)
EC2.7.11.1
Consensus CDS ProjectCCDS20903.1
International Mouse Knockout Project StatusMark4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 232944 NCBI Gene Model | MGI Sequence Detail 32420 C57BL/6J ±  kb
transcript NM_172279 RefSeq | MGI Sequence Detail 2259 Swiss Webster 
polypeptide Q8CIP4 UniProt | EBI | MGI Sequence Detail 752 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(294 from dbSNP Build 137)    SNPs within 2kb including multiple locations(296)
Protein-related
information
ResourceIDDescription
InterPro IPR001772 Kinase associated domain 1 (KA1)
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR000449 Ubiquitin-associated/translation elongation factor EF1B, N-terminal
InterPro IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
Protein Ontology PR:000010189 MAP/microtubule affinity-regulating kinase 4
Graphical View of Protein Domain Structure
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:195206 Kuhns S, et al., The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis. J Cell Biol. 2013 Feb 18;200(4):505-22
All references(30)
Other
accession IDs
MGI:2142337

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory