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Mark4 Gene Detail
Summary
  • Symbol
    Mark4
  • Name
    MAP/microtubule affinity regulating kinase 4
  • Synonyms
    2410090P21Rik, Markl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920955
    NCBI Gene: 232944
  • Gene Overview
    MyGene.info: MARK4
Location & Maps
more
  • Sequence Map
    Chr7:19424775-19458821 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34047 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 9.78 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MARK4, microtubule affinity regulating kinase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MARK4, microtubule affinity regulating kinase 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MARK4L, MARK4S, MARKL1, MARKL1L, PAR-1D
  • Links
    NCBI Gene ID: 57787
    neXtProt AC: NX_Q96L34

  • Chr Location
    19q13.3; chr19:45251258-45305283 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit insulin hypersensitivity and resistance to diet-induced obersity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000059238 VEGA Gene Model | MGI Sequence Detail 34047 C57BL/6J ±  kb
transcript OTTMUST00000145367 VEGA | MGI Sequence Detail 3886 Not Applicable  
polypeptide OTTMUSP00000075743 VEGA | MGI Sequence Detail 752 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    296 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 8
    cDNA 7
    Other 1

    Microarray probesets 8
Other
Accession IDs
less
MGI:2142337
References
more
  • Summaries
    All 30
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:195206 Kuhns S, et al., The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis. J Cell Biol. 2013 Feb 18;200(4):505-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory