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Stk36
Gene Detail
Symbol

Name
ID
Stk36
serine/threonine kinase 36
MGI:1920831
Synonyms
1700112N14Rik, Fused
Feature Type
protein coding gene
Genetic Map
Chromosome 1
38.54 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:74601445-74636894 bp, + strand
From VEGA annotation of GRCm38

  35450 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49432  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Stk36

Human
homologs
Human Homolog STK36, serine/threonine kinase 36
NCBI Gene ID 27148
neXtProt AC  NX_Q9NRP7
Human Synonyms  FU
Human Chr (Location)  2q35; chr2:218672026-218702717 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for one knock-out allele become runty and emaciated and die before 3 wks of age. Homozygotes for another knock-out allele show a similar growth arrest and mortality in addition to hydrocephalus, a domed head, ataxia, rhinitis, immature lungs and kidneys, and thymus and spleen atrophy.
 
Interactions
Stk36 interacts with 201 markers (Mir1b, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process brain development, cell projection organization, ...
Component cytoplasm, nucleus
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (178)    Tissues (46)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 176
Northern blot 2
cDNA source data(48)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(50) cDNA(48) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000021747 (Evidence)
Ensembl Gene ModelENSMUSG00000033276 (Evidence)
Entrez Gene269209 (Evidence)
UniGene310974
DFCITC1624165, TC1614313, TC1595143, TC1581130, TC1589191, TC1588227
DoTSDT.101736454, DT.110934425, DT.91329604, DT.524097, DT.101210889, DT.101244797, DT.94172035
NIA Mouse Gene IndexU000456
EC2.7.11.1
Consensus CDS ProjectCCDS35619.1
International Mouse Knockout Project StatusStk36
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021747 VEGA Gene Model | MGI Sequence Detail 35450 C57BL/6J ±  kb
transcript OTTMUST00000051614 VEGA | MGI Sequence Detail 5245 Not Applicable 
polypeptide OTTMUSP00000024329 VEGA | MGI Sequence Detail 1316 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(6) UniProt(8)
Polymorphisms
SNPs within 2kb(298 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000015753 serine/threonine-protein kinase 36
References
(Earliest) J:113893 Murone M, et al., Gli regulation by the opposing activities of fused and suppressor of fused. Nat Cell Biol. 2000 May;2(5):310-2
(Latest) J:208762 Nozawa YI, et al., Mammalian Fused is essential for sperm head shaping and periaxonemal structure formation during spermatogenesis. Dev Biol. 2014 Apr 15;388(2):170-80
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory