Stk36
Gene Detail

Symbol Name ID

Stk36 serine/threonine kinase 36 MGI:1920831

Synonyms

1700112N14Rik, Fused

Feature Type

protein coding gene

Genetic Map

Chromosome 1

38.54 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:74601445-74636894 bp, + strand From VEGA annotation of GRCm38   35450 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:49432  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Stk36

Human homologs

Human Homolog		STK36, serine/threonine kinase 36
NCBI Gene ID		27148
neXtProt AC		NX_Q9NRP7
Human Synonyms		FU
Human Chr (Location)		2q35; chr2:219536749-219567440 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Homozygotes for one knock-out allele become runty and emaciated and die before 3 wks of age. Homozygotes for another knock-out allele show a similar growth arrest and mortality in addition to hydrocephalus, a domed head, ataxia, rhinitis, immature lungs and kidneys, and thymus and spleen atrophy.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	brain development, cell projection organization, ...
Component	cytoplasm, nucleus
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (172)    Tissues (40)    Images (26)
Theiler Stages: 21, 23

Assay Type	Results
RNA in situ	172

cDNA source data(46)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(47) cDNA(46) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000021747 (Evidence)
Ensembl Gene Model	ENSMUSG00000033276 (Evidence)
Entrez Gene	269209 (Evidence)
UniGene	310974
DFCI	TC1581130, TC1588227, TC1589191, TC1595143, TC1614313, TC1624165
DoTS	DT.101210889, DT.101244797, DT.101736454, DT.110934425, DT.524097, DT.91329604, DT.94172035
NIA Mouse Gene Index	U000456
EC	2.7.11.1
Consensus CDS Project	CCDS35619.1
International Mouse Knockout Project Status	Stk36

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021747	VEGA Gene Model | MGI Sequence Detail	35450	C57BL/6J
transcript	OTTMUST00000051614	VEGA | MGI Sequence Detail	5245	Not Applicable
polypeptide	OTTMUSP00000024329	VEGA | MGI Sequence Detail	1316	Not Applicable

All sequences(63) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(151 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011989	Armadillo-like helical
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000015753	serine/threonine-protein kinase 36

References

(Earliest) J:113893 Murone M, et al., Gli regulation by the opposing activities of fused and suppressor of fused. Nat Cell Biol. 2000 May;2(5):310-2
(Latest) J:185566 Vogel P, et al., Congenital hydrocephalus in genetically engineered mice. Vet Pathol. 2012 Jan;49(1):166-81
All references(36)