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Stk36 Gene Detail
Summary
  • Symbol
    Stk36
  • Name
    serine/threonine kinase 36
  • Synonyms
    1700112N14Rik, Fused
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920831
    NCBI Gene: 269209
  • Gene Overview
    MyGene.info: STK36
Location & Maps
more
  • Sequence Map
    Chr1:74601445-74636894 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      35450 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    STK36, serine/threonine kinase 36
  • Vertebrate Orthologs
    8
  • Human Ortholog
    STK36, serine/threonine kinase 36
    Orthology source: HomoloGene
  • Synonyms
    FU
  • Links
    NCBI Gene ID: 27148
    neXtProt AC: NX_Q9NRP7

  • Chr Location
    2q35; chr2:218672026-218702717 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 4 alleles in 4 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    1
  • Radiation induced
    2
  • Targeted
    4
  • Genomic Mutations
    3 involving Stk36
  • Incidental Mutations
Nullizygous mutations cause postnatal growth defects and lethality. Homozygotes for a null allele show hydrocephaly, cranial defects, otitis media and sterility. Homozygotes for another null allele show additional defects in lung and renal development, thymus and spleen atrophy, rhinitis and ataxia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021747 VEGA Gene Model | MGI Sequence Detail 35450 C57BL/6J ±  kb
transcript OTTMUST00000051614 VEGA | MGI Sequence Detail 5245 Not Applicable  
polypeptide OTTMUSP00000024329 VEGA | MGI Sequence Detail 1316 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    294 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 50
    cDNA 48
    Primer pair 1
    Other 1

    Microarray probesets 5
References
more
  • Summaries
    All 35
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 19
  • Earliest
    J:113893 Murone M, et al., Gli regulation by the opposing activities of fused and suppressor of fused. Nat Cell Biol. 2000 May;2(5):310-2
  • Latest
    J:208762 Nozawa YI, et al., Mammalian Fused is essential for sperm head shaping and periaxonemal structure formation during spermatogenesis. Dev Biol. 2014 Apr 15;388(2):170-80

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory