About   Help   FAQ
Izumo1
Gene Detail
Symbol

Name
ID
Izumo1
izumo sperm-egg fusion 1
MGI:1920706
Synonyms
1700058F15Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 7
29.39 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:45621811-45628823 bp, + strand
From VEGA annotation of GRCm38

  7013 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:77701  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

HCOP human homology predictions: IZUMO1
Gene Tree: Izumo1

Human
homologs
IZUMO1, izumo sperm-egg fusion 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 284359
neXtProt AC: NX_Q8IYV9

Human Synonyms: IZUMO

Human Chr (Location): 19q13.33; chr19:48740888-48747650 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null male mice are infertile due to inability of sperm to fuse with the egg.
 
Interactions
Izumo1 interacts with 13 markers (Mir10a, Mir10b, Mir218-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell adhesion, fusion of sperm to egg plasma membrane, ...
Component acrosomal membrane, acrosomal vesicle, ...
Function protein binding, protein homodimerization activity, ...
External Resources: FuncBase
Expression
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(9) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000029510 (Evidence)
Ensembl Gene Model ENSMUSG00000064158 (Evidence)
Entrez Gene 73456 (Evidence)
UniGene 380445
DFCI TC1586808
DoTS DT.521810
Consensus CDS Project CCDS21255.1
International Mouse Phenotyping Consortium Status Izumo1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029510 VEGA Gene Model | MGI Sequence Detail 7013 C57BL/6J ±  kb
transcript OTTMUST00000073125 VEGA | MGI Sequence Detail 1493 Not Applicable 
polypeptide OTTMUSP00000037822 VEGA | MGI Sequence Detail 397 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(75 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003599 Immunoglobulin subtype
Protein Ontology PR:000009171 izumo sperm-egg fusion protein 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:209568 Bianchi E, et al., Juno is the egg Izumo receptor and is essential for mammalian fertilization. Nature. 2014 Apr 24;508(7497):483-7
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory