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Izumo1 Gene Detail
Summary
  • Symbol
    Izumo1
  • Name
    izumo sperm-egg fusion 1
  • Synonyms
    1700058F15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920706
    NCBI Gene: 73456
  • Gene Overview
    MyGene.info: IZUMO1
Location & Maps
more
  • Sequence Map
    Chr7:45621811-45627242 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5432 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.39 cM, cytoband B2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    IZUMO1, izumo sperm-egg fusion 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    IZUMO1, izumo sperm-egg fusion 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IZUMO, OBF
  • Links
    NCBI Gene ID: 284359
    neXtProt AC: NX_Q8IYV9

  • Chr Location
    19q13.33; chr19:48740888-48747650 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Gene trapped
    1
  • Targeted
    2
  • Incidental Mutations
Homozygous null male mice are infertile due to inability of sperm to fuse with the egg.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 73456 NCBI Gene Model | MGI Sequence Detail 5432 C57BL/6J ±  kb
transcript NM_001018013 RefSeq | MGI Sequence Detail 1493 C57BL/6  
polypeptide Q9D9J7 UniProt | EBI | MGI Sequence Detail 397 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    63 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000009171 izumo sperm-egg fusion protein 1
  • InterPro Domains
    IPR007110 Immunoglobulin-like domain
    IPR032699 Izumo protein, immunoglobulin domain
    IPR029389 Izumo sperm-egg fusion protein
    IPR032700 Izumo sperm-egg fusion protein 1
Molecular
Reagents
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  • All nucleic 10
    cDNA 9
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 35
    Gene Ontology 9
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:228028 Inoue N, et al., Oocyte-triggered dimerization of sperm IZUMO1 promotes sperm-egg fusion in mice. Nat Commun. 2015;6:8858

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory