Izumo1 MGI Mouse Gene Detail - MGI:1920706

Symbol

Izumo1
Name

izumo sperm-egg fusion 1
Synonyms

1700058F15Rik

Feature Type

protein coding gene
IDs

MGI:1920706
NCBI Gene: 73456
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr7:45270251-45276653 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 29.39 cM, cytoband B2
Mapping Data

2 experiments

SNPs within 2kb

68 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920706	protein coding gene	Chr7:45270251-45278247 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032234	protein coding gene	Chr7:45921552-45928561 (+)
A/J	MGP_AJ_G0032213	protein coding gene	Chr7:45015960-45022959 (+)
AKR/J	MGP_AKRJ_G0032149	protein coding gene	Chr7:46264921-46271926 (+)
BALB/cJ	MGP_BALBcJ_G0032225	protein coding gene	Chr7:45009677-45016637 (+)
C3H/HeJ	MGP_C3HHeJ_G0031940	protein coding gene	Chr7:46755709-46763136 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032717	protein coding gene	Chr7:48175999-48182991 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029731	protein coding gene	Chr7:47561422-47568180 (+)
CAST/EiJ	MGP_CASTEiJ_G0031269	protein coding gene	Chr7:38193779-38202696 (+)
CBA/J	MGP_CBAJ_G0031905	protein coding gene	Chr7:49779066-49785908 (+)
DBA/2J	MGP_DBA2J_G0032063	protein coding gene	Chr7:44693868-44701048 (+)
FVB/NJ	MGP_FVBNJ_G0032014	protein coding gene	Chr7:44466580-44473848 (+)
LP/J	MGP_LPJ_G0032141	protein coding gene	Chr7:46625822-46636195 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032051	protein coding gene	Chr7:48464052-48471336 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032733	protein coding gene	Chr7:45474618-45484076 (+)
PWK/PhJ	MGP_PWKPhJ_G0030991	protein coding gene	Chr7:38061626-38069046 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030829	protein coding gene	Chr7:33502677-33509472 (+)
WSB/EiJ	MGP_WSBEiJ_G0031386	protein coding gene	Chr7:45978995-45987379 (+)

Human Ortholog

IZUMO1, izumo sperm-oocyte fusion 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IZUMO1, izumo sperm-oocyte fusion 1
Synonyms

IZUMO, OBF
Links

HGNC:28539

NCBI Gene ID: 284359

neXtProt AC: NX_Q8IYV9

UniProt: Q8IYV9
Chr Location

19q13.33; chr19:48740852-48746909 (-) GRCh38

MGI Vertebrate Homology

Izumo1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: IZUMO1
Gene Tree

Izumo1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Gene trapped

1
Targeted

2
Transgenic

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null male mice are infertile due to inability of sperm to fuse with the egg.

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All GO Annotations

32
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

9

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

40
RefSeq

12
UniProt

1
CCDS

CCDS21255.1

Ensembl

ENSMUSG00000064158 (Evidence)
NCBI Gene

73456

			Length	Strain/Species	Flank
genomic	73456	NCBI Gene Model \| MGI Sequence Detail	6403	C57BL/6J	± kb
transcript	NM_001018013	RefSeq \| MGI Sequence Detail	1460	C57BL/6
polypeptide	Q9D9J7	UniProt \| EBI \| MGI Sequence Detail	397	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000009171 izumo sperm-egg fusion protein 1

(term hierarchy)
PDB

5B5K
InterPro Domains

IPR036179 Immunoglobulin-like domain superfamily

IPR032699 Izumo protein, immunoglobulin domain

IPR029389 Izumo sperm-egg fusion protein

IPR032700 Izumo sperm-egg fusion protein 1

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All nucleic 10

cDNA 10

Microarray probesets 3

Summaries

All 52

Gene Ontology 15

Phenotypes 20
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:333062 Brukman NG, et al., A novel function for the sperm adhesion protein IZUMO1 in cell-cell fusion. J Cell Biol. 2023 Feb 6;222(2)

TSS for Izumo1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr66591	Chr7:45270232-45270261 (+)	-4 bp
Tssr66592	Chr7:45271207-45271220 (+)	963 bp
Tssr66593	Chr7:45271229-45271249 (+)	988 bp
Tssr66594	Chr7:45271251-45271265 (+)	1,007 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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