Sequence Detail

ID/Version

Q9D9J7 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Izumo sperm-egg fusion protein 1 {ECO:0000305};AltName: Full=Oocyte binding/fusion factor {ECO:0000303|PubMed:15759005}; Short=OBF {ECO:0000303|PubMed:15759005};AltName: Full=Sperm-specific protein izumo {ECO:0000303|PubMed:15759005}

Provider

SWISS-PROT

Sequence

Polypeptide 397 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Izumo1	izumo sperm-egg fusion 1	45	96	2	7

Sequence references in MGI

J:97563 Inoue N, et al., The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs. Nature. 2005 Mar 10;434(7030):234-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:144869 Inoue N, et al., Putative sperm fusion protein IZUMO and the role of N-glycosylation. Biochem Biophys Res Commun. 2008 Dec 19;377(3):910-4
J:155060 Ellerman DA, et al., Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm. Mol Reprod Dev. 2009 Dec;76(12):1188-99
J:160139 Inoue N, et al., Identification and disruption of sperm-specific angiotensin converting enzyme-3 (ACE3) in mouse. PLoS One. 2010;5(4):e10301
J:209568 Bianchi E, et al., Juno is the egg Izumo receptor and is essential for mammalian fertilization. Nature. 2014 Apr 24;508(7497):483-7
J:228028 Inoue N, et al., Oocyte-triggered dimerization of sperm IZUMO1 promotes sperm-egg fusion in mice. Nat Commun. 2015;6:8858
J:235303 Ohto U, et al., Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization. Nature. 2016 Jun 23;534(7608):566-9
J:258196 Young SA, et al., CRISPR/Cas9-mediated mutation revealed cytoplasmic tail is dispensable for IZUMO1 function and male fertility. Reproduction. 2016 Dec;152(6):665-672
J:278260 Inoue N, et al., Monitoring dimeric status of IZUMO1 during the acrosome reaction in living spermatozoon. Cell Cycle. 2018;17(11):1279-1285
J:289090 Lamas-Toranzo I, et al., TMEM95 is a sperm membrane protein essential for mammalian fertilization. Elife. 2020 Jun 2;9:e53913
J:289149 Noda T, et al., Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm-oocyte fusion in mice. Proc Natl Acad Sci U S A. 2020 May 26;117(21):11493-11502
J:290694 Gaikwad AS, et al., GLIPR1L1 is an IZUMO-binding protein required for optimal fertilization in the mouse. BMC Biol. 2019 Oct 31;17(1):86
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:326368 Kaneda Y, et al., IRGC1, a testis-enriched immunity related GTPase, is important for fibrous sheath integrity and sperm motility in mice. Dev Biol. 2022 Aug;488:104-113
J:328498 Contreras W, et al., C11orf94/Frey is a key regulator for male fertility by controlling Izumo1 complex assembly. Sci Adv. 2022 Aug 12;8(32):eabo6049
J:333062 Brukman NG, et al., A novel function for the sperm adhesion protein IZUMO1 in cell-cell fusion. J Cell Biol. 2023 Feb 6;222(2)
J:337404 Matsumura T, et al., Sperm IZUMO1 Is Required for Binding Preceding Fusion With Oolemma in Mice and Rats. Front Cell Dev Biol. 2021;9:810118
J:355669 Jean C, et al., JUNO, the receptor of sperm IZUMO1, is expressed by the human oocyte and is essential for human fertilisation. Hum Reprod. 2019 Jan 1;34(1):118-126
J:359376 Chalbi M, et al., Binding of sperm protein Izumo1 and its egg receptor Juno drives Cd9 accumulation in the intercellular contact area prior to fusion during mammalian fertilization. Development. 2014 Oct;141(19):3732-9