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Wasl Gene Detail
Summary
  • Symbol
    Wasl
  • Name
    WASP like actin nucleation promoting factor
  • Synonyms
    2900021I12Rik, 3110031I02Rik, N-WASP, Wiskott-Aldrich syndrome-like (human)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920428
    NCBI Gene: 73178
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:24613804-24665008 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 11.28 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    189 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920428
protein coding gene Chr6:24613804-24665185 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030497
protein coding gene Chr6:22179630-22233049 (-)
A/J MGP_AJ_G0030470
protein coding gene Chr6:21253306-21305311 (-)
AKR/J MGP_AKRJ_G0030397
protein coding gene Chr6:21932624-21983749 (-)
BALB/cJ MGP_BALBcJ_G0030480
protein coding gene Chr6:21360685-21412929 (-)
C3H/HeJ MGP_C3HHeJ_G0030193
protein coding gene Chr6:21933389-21986931 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030934
protein coding gene Chr6:22880104-22931272 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028145
protein coding gene Chr6:19710172-19761867 (-)
CAST/EiJ MGP_CASTEiJ_G0029595
protein coding gene Chr6:21788541-21843271 (-)
CBA/J MGP_CBAJ_G0030171
protein coding gene Chr6:23653622-23709779 (-)
DBA/2J MGP_DBA2J_G0030315
protein coding gene Chr6:21210788-21262509 (-)
FVB/NJ MGP_FVBNJ_G0030269
protein coding gene Chr6:20973161-21025918 (-)
LP/J MGP_LPJ_G0030402
protein coding gene Chr6:22333267-22396984 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030305
protein coding gene Chr6:25570471-25628374 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030964
protein coding gene Chr6:21862557-21915201 (-)
PWK/PhJ MGP_PWKPhJ_G0029309
protein coding gene Chr6:20776129-20828433 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029145
protein coding gene Chr6:21593395-21648383 (-)
WSB/EiJ MGP_WSBEiJ_G0029671
protein coding gene Chr6:21830145-21884278 (-)



Homology
more
  • Human Ortholog
    WASL, WASP like actin nucleation promoting factor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WASL, WASP like actin nucleation promoting factor
  • Synonyms
    NWASP, N-WASP, WASPB
  • Links
    NCBI Gene ID: 8976
    neXtProt AC: NX_O00401
    UniProt: O00401

  • Chr Location
    7q31.32; chr7:123681943-123749003 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with Wasl mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    70 phenotypes from 6 alleles in 6 genetic backgrounds
    10 phenotypes from multigenic genotypes
    1 images
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit developmental retardation, fail to undergo turning, show abnormal differentiation of intra- and extra-embryonal mesoderm, and die around midgestation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029684 Ensembl Gene Model | MGI Sequence Detail 51205 C57BL/6J ±  kb
    transcript ENSMUST00000031695 Ensembl | MGI Sequence Detail 4352 Not Applicable  
    polypeptide ENSMUSP00000031695 Ensembl | MGI Sequence Detail 501 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 139
      cDNA 138
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1920097
    References
    more
    • Summaries
      All 111
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 18
      Phenotypes 39
    • Earliest
      J:66805 Modregger J, et al., All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis. J Cell Sci. 2000 Dec;113 Pt 24:4511-21
    • Latest
      J:341359 Kalailingam P, et al., Conditional Knockout of N-WASP Enhanced the Formation of Keratinizing Squamous Cell Carcinoma Induced by KRas(G12D). Cancers (Basel). 2023 Sep 7;15(18)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory