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Wasl Gene Detail
Summary
  • Symbol
    Wasl
  • Name
    Wiskott-Aldrich syndrome-like (human)
  • Synonyms
    2900021I12Rik, 3110031I02Rik, N-WASP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920428
    NCBI Gene: 73178
  • Gene Overview
    MyGene.info: WASL
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:24613810-24664995 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 11.28 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    189 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920428
protein coding gene Chr6:24613805-24665009 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030497
protein coding gene Chr6:22179630-22233049 (-)
A/J MGP_AJ_G0030470
protein coding gene Chr6:21253306-21305311 (-)
AKR/J MGP_AKRJ_G0030397
protein coding gene Chr6:21932624-21983749 (-)
BALB/cJ MGP_BALBcJ_G0030480
protein coding gene Chr6:21360685-21412929 (-)
C3H/HeJ MGP_C3HHeJ_G0030193
protein coding gene Chr6:21933389-21986931 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030934
protein coding gene Chr6:22880104-22931272 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028145
protein coding gene Chr6:19710172-19761867 (-)
CAST/EiJ MGP_CASTEiJ_G0029595
protein coding gene Chr6:21788541-21843271 (-)
CBA/J MGP_CBAJ_G0030171
protein coding gene Chr6:23653622-23709779 (-)
DBA/2J MGP_DBA2J_G0030315
protein coding gene Chr6:21210788-21262509 (-)
FVB/NJ MGP_FVBNJ_G0030269
protein coding gene Chr6:20973161-21025918 (-)
LP/J MGP_LPJ_G0030402
protein coding gene Chr6:22333267-22396984 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030305
protein coding gene Chr6:25570471-25628374 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030964
protein coding gene Chr6:21862557-21915201 (-)
PWK/PhJ MGP_PWKPhJ_G0029309
protein coding gene Chr6:20776129-20828433 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029145
protein coding gene Chr6:21593395-21648383 (-)
WSB/EiJ MGP_WSBEiJ_G0029671
protein coding gene Chr6:21830145-21884278 (-)



Homology
more
  • Human Ortholog
    WASL, WASP like actin nucleation promoting factor
  • Vertebrate Orthologs
    2
  • Human Ortholog
    WASL, WASP like actin nucleation promoting factor
    Orthology source: HGNC
  • Synonyms
    NWASP, N-WASP, WASPB
  • Links
    NCBI Gene ID: 8976
    neXtProt AC: NX_O00401
    UniProt: O00401

  • Chr Location
    7q31.32; chr7:123681927-123749071 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Wasl mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    70 phenotypes from 6 alleles in 6 genetic backgrounds
    10 phenotypes from multigenic genotypes
    1 images
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit developmental retardation, fail to undergo turning, show abnormal differentiation of intra- and extra-embryonal mesoderm, and die around midgestation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 73178 NCBI Gene Model | MGI Sequence Detail 51186 C57BL/6J ±  kb
    transcript NM_028459 RefSeq | MGI Sequence Detail 4348 C57BL/6  
    polypeptide Q91YD9 UniProt | EBI | MGI Sequence Detail 501 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 139
      cDNA 138
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1920097
    References
    more
    • Summaries
      All 97
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 17
      Phenotypes 29
    • Earliest
      J:66805 Modregger J, et al., All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis. J Cell Sci. 2000 Dec;113 Pt 24:4511-21
    • Latest
      J:274262 Li H, et al., Negative Regulation of p53-Induced Senescence by N-WASP Is Crucial for DMBA/TPA-Induced Skin Tumor Formation. Cancer Res. 2019 May 1;79(9):2167-2181

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory