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Wasl
Gene Detail
Symbol

Name
ID
Wasl
Wiskott-Aldrich syndrome-like (human)
MGI:1920428
Synonyms
2900021I12Rik, 3110031I02Rik, N-WASP
Feature Type
protein coding gene
Genetic Map
Chromosome 6
11.28 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:24613805-24665009 bp, - strand
From VEGA annotation of GRCm38

  51205 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:135996  Vertebrate Homology Class
1 mouse; 1 rat

Protein SuperFamily: Wasp protein, metazoan type
Gene Tree: Wasl

Mutations,
alleles, and
phenotypes
All mutations/alleles(42) : Gene trapped(35) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants exhibit developmental retardation, fail to undergo turning, show abnormal differentiation of intra- and extra-embryonal mesoderm, and die around midgestation.
 
Phenotype Images(1)
Interactions
Wasl interacts with 381 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process actin cytoskeleton organization, actin filament organization, ...
Component actin cap, cytoplasm, ...
Function actin binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (24)    Tissues (15)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
cDNA source data(136)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(137) cDNA(137)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037666 (Evidence)
Ensembl Gene ModelENSMUSG00000029684 (Evidence)
Entrez Gene73178 (Evidence)
UniGene1574
DFCITC1593065, TC1572372
DoTSDT.50317000, DT.97345935
NIA Mouse Gene IndexU027087
PDB3M3N
Consensus CDS ProjectCCDS19945.1, CCDS51727.1
International Mouse Knockout Project StatusWasl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037666 VEGA Gene Model | MGI Sequence Detail 51205 C57BL/6J ±  kb
transcript OTTMUST00000097259 VEGA | MGI Sequence Detail 4352 Not Applicable 
polypeptide OTTMUSP00000054515 VEGA | MGI Sequence Detail 501 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(4) UniProt(21)
Polymorphisms
SNPs within 2kb(189 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000697 EVH1
InterPro IPR000095 PAK-box/P21-Rho-binding
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR003124 WH2 domain
InterPro IPR011026 Wiscott-Aldrich syndrome, C-terminal
Protein Ontology PR:000017375 neural Wiskott-Aldrich syndrome protein
References
(Earliest) J:66805 Modregger J, et al., All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis. J Cell Sci. 2000 Dec;113 Pt 24:4511-21
(Latest) J:208336 Kesavan G, et al., Cdc42/N-WASP signaling links actin dynamics to pancreatic beta cell delamination and differentiation. Development. 2014 Feb;141(3):685-96
All references(74)
Other
accession IDs
MGI:1920097

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory