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Wasl Gene Detail
Summary
  • Symbol
    Wasl
  • Name
    Wiskott-Aldrich syndrome-like (human)
  • Synonyms
    2900021I12Rik, 3110031I02Rik, N-WASP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920428
    NCBI Gene: 73178
  • Gene Overview
    MyGene.info: WASL
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:24613805-24665009 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      51205 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 11.28 cM, cytoband A3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    WASL, Wiskott-Aldrich syndrome like
  • Vertebrate Orthologs
    2
  • Human Ortholog
    WASL, Wiskott-Aldrich syndrome like
    Orthology source: HGNC
  • Synonyms
    NWASP, N-WASP, WASPB
  • Links
    NCBI Gene ID: 8976
    neXtProt AC: NX_O00401
    UniProt: O00401

  • Chr Location
    7q31.32; chr7:123681927-123749071 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    50 phenotypes from 6 alleles in 5 genetic backgrounds
    10 phenotypes from multigenic genotypes
    1 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit developmental retardation, fail to undergo turning, show abnormal differentiation of intra- and extra-embryonal mesoderm, and die around midgestation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000037666 VEGA Gene Model | MGI Sequence Detail 51205 C57BL/6J ±  kb
    transcript OTTMUST00000097259 VEGA | MGI Sequence Detail 4352 Not Applicable  
    polypeptide OTTMUSP00000054515 VEGA | MGI Sequence Detail 501 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      189 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 138
      cDNA 137
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1920097
    References
    more
    • Summaries
      All 89
      Developmental Gene Expression 6
      Gene Ontology 15
      Phenotypes 24
    • Earliest
      J:66805 Modregger J, et al., All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis. J Cell Sci. 2000 Dec;113 Pt 24:4511-21
    • Latest
      J:239487 Wagener BM, et al., Neuronal Wiskott-Aldrich syndrome protein regulates TGF-beta1-mediated lung vascular permeability. FASEB J. 2016 Jul;30(7):2557-69

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory