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Pfn4 Gene Detail
Summary
  • Symbol
    Pfn4
  • Name
    profilin family, member 4
  • Synonyms
    2900024P18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920121
    NCBI Gene: 382562
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:4769167-4778808 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 2.09 cM, cytoband A1.1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    72 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920121
protein coding gene Chr12:4769022-4778813 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019573
protein coding gene Chr12:1679778-1688791 (+)
A/J MGP_AJ_G0019540
protein coding gene Chr12:1655845-1664773 (+)
AKR/J MGP_AKRJ_G0019510
protein coding gene Chr12:1847760-1856460 (+)
BALB/cJ MGP_BALBcJ_G0019515
protein coding gene Chr12:1692997-1701967 (+)
C3H/HeJ MGP_C3HHeJ_G0019321
protein coding gene Chr12:1623097-1632115 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019964
protein coding gene Chr12:1709888-1718820 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017589
protein coding gene Chr12:1570617-1579736 (+)
CAST/EiJ MGP_CASTEiJ_G0018876
protein coding gene Chr12:1705484-1714323 (+)
CBA/J MGP_CBAJ_G0019292
protein coding gene Chr12:2041436-2050454 (+)
DBA/2J MGP_DBA2J_G0019405
protein coding gene Chr12:1589352-1598362 (+)
FVB/NJ MGP_FVBNJ_G0019396
protein coding gene Chr12:1600954-1609961 (+)
LP/J MGP_LPJ_G0019476
protein coding gene Chr12:1694781-1703706 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019429
protein coding gene Chr12:1779625-1788554 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020003
protein coding gene Chr12:1652802-1661809 (+)
PWK/PhJ MGP_PWKPhJ_G0018642
protein coding gene Chr12:1646811-1656147 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018433
protein coding gene Chr12:1692490-1698503 (+)
WSB/EiJ MGP_WSBEiJ_G0018927
protein coding gene Chr12:1648749-1657687 (+)



Homology
more
  • Human Ortholog
    PFN4, profilin family member 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PFN4, profilin family member 4
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 375189
    neXtProt AC: NX_Q8NHR9
    UniProt: Q8NHR9

  • Chr Location
    2p23.3; chr2:24114809-24123491 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 382562 NCBI Gene Model | MGI Sequence Detail 9642 C57BL/6J ±  kb
transcript NM_028376 RefSeq | MGI Sequence Detail 1870 C57BL/6  
polypeptide Q9D6I3 UniProt | EBI | MGI Sequence Detail 129 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 2
References
more
  • Summaries
    All 26
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory