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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pfn4
profilin family, member 4
MGI:1920121
34 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pfn4em1Hsc/Pfn4em1Hsc
C57BL/6J-Pfn4em1Hsc 		abnormal acrosome assembly J:328252
abnormal acrosome morphology J:328252
abnormal Golgi apparatus morphology J:328252
abnormal Golgi vesicle transport J:328252
abnormal manchette assembly J:328252
abnormal manchette morphology J:328252
abnormal proacrosomal vesicle fusion J:328252
abnormal sperm connecting piece morphology J:328252
abnormal sperm flagellum morphology J:328252
abnormal sperm head morphology J:328252
abnormal sperm midpiece morphology J:328252
abnormal sperm mitochondrial sheath morphology J:328252
abnormal sperm nucleus morphology J:328252
abnormal spermatid morphology J:328252
abnormal spermiogenesis J:328252
abnormal testis physiology J:328252
absent manchette J:328252
asthenozoospermia J:328252
normal cellular phenotype J:328252
coiled sperm flagellum J:328252
decreased sperm progressive motility J:328252
globozoospermia J:328252
impaired acrosome reaction J:328252
impaired autophagy J:328252
impaired fertilization J:328252
male infertility J:328252
necrospermia J:328252
normal reproductive system phenotype J:328252
small sperm head J:328252
Pfn4em2Hsc/Pfn4em2Hsc
C57BL/6J-Pfn4em2Hsc 		abnormal acrosome assembly J:328252
abnormal acrosome morphology J:328252
abnormal Golgi apparatus morphology J:328252
abnormal Golgi vesicle transport J:328252
abnormal manchette assembly J:328252
abnormal manchette morphology J:328252
abnormal proacrosomal vesicle fusion J:328252
abnormal sperm connecting piece morphology J:328252
abnormal sperm flagellum morphology J:328252
abnormal sperm head morphology J:328252
abnormal sperm midpiece morphology J:328252
abnormal sperm mitochondrial sheath morphology J:328252
abnormal sperm nucleus morphology J:328252
abnormal spermatid morphology J:328252
abnormal spermiogenesis J:328252
abnormal testis physiology J:328252
absent manchette J:328252
asthenozoospermia J:328252
normal cellular phenotype J:328252
coiled sperm flagellum J:328252
decreased sperm progressive motility J:328252
globozoospermia J:328252
impaired acrosome reaction J:328252
impaired autophagy J:328252
impaired fertilization J:328252
male infertility J:328252
necrospermia J:328252
reproductive system phenotype J:328252
normal reproductive system phenotype J:328252
small sperm head J:328252
Pfn4tm1b(KOMP)Wtsi/Pfn4tm1b(KOMP)Wtsi
C57BL/6N-Pfn4tm1b(KOMP)Wtsi/MbpMmucd 		decreased bronchoconstrictive response J:211773
decreased pulmonary ventilation J:211773
increased pulmonary respiratory rate J:211773
Pfn4tm1b(KOMP)Wtsi/Pfn4tm1b(KOMP)Wtsi
C57BL/6N-Pfn4tm1b(KOMP)Wtsi/Ucd 		abnormal tail morphology J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory