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Cox15
Gene Detail
 Symbol
Name
ID
Cox15
cytochrome c oxidase assembly protein 15
MGI:1920112
Synonyms 2900026G05Rik
Feature Type protein coding gene
Genetic Map
Chromosome 19
36.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:43733254-43753000 bp, - strand
From VEGA annotation of GRCm38

  19747 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5848  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cox15

Human
homologs
Human Homolog COX15, cytochrome c oxidase assembly homolog 15 (yeast)
NCBI Gene ID 1355
neXtProt AC  NX_Q7KZN9
Human Synonyms  CEMCOX2
Human Chr (Location)  10q24; chr10:99696131-99732666 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human COX15
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit embryonic lethality.
 
Interactions
Cox15 interacts with 329 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process heme a biosynthetic process, hydrogen ion transmembrane transport, ...
Component integral component of membrane, membrane, ...
Function catalytic activity, cytochrome-c oxidase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000026393 (Evidence)
Ensembl Gene ModelENSMUSG00000040018 (Evidence)
Entrez Gene226139 (Evidence)
Consensus CDS ProjectCCDS29836.1
International Mouse Knockout Project StatusCox15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026393 VEGA Gene Model | MGI Sequence Detail 19747 C57BL/6J ±  kb
transcript OTTMUST00000065269 VEGA | MGI Sequence Detail 4798 Not Applicable 
polypeptide OTTMUSP00000032506 VEGA | MGI Sequence Detail 413 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(141 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003780 Heme A synthase
InterPro IPR023754 Heme A synthase, type 2
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000005771 cytochrome c oxidase assembly protein COX15
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:176080 Viscomi C, et al., In vivo correction of COX deficiency by activation of the AMPK/PGC-1alpha axis. Cell Metab. 2011 Jul 6;14(1):80-90
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory