Cox15
Gene Detail

Symbol Name ID

Cox15 cytochrome c oxidase assembly protein 15 MGI:1920112

Synonyms

2900026G05Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 19

36.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr19:43733254-43753000 bp, - strand From VEGA annotation of GRCm38   19747 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5848  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Cox15

Human homologs

Human Homolog		COX15, cytochrome c oxidase assembly homolog 15 (yeast)
NCBI Gene ID		1355
neXtProt AC		NX_Q7KZN9
Human Synonyms		CEMCOX2
Human Chr (Location)		10q24; chr10:101468505-101492423 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human COX15

Alleles and phenotypes

All alleles(7) : Targeted(3) Gene trapped(4)
 

Mice homozygous for a knock-out allele exhibit embryonic lethality.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	heme a biosynthetic process, oxidation-reduction process, ...
Component	integral to membrane, membrane, ...
Function	catalytic activity, cytochrome-c oxidase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) cDNA(9)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000026393 (Evidence)
Ensembl Gene Model	ENSMUSG00000040018 (Evidence)
Entrez Gene	226139 (Evidence)
Consensus CDS Project	CCDS29836.1
International Mouse Knockout Project Status	Cox15

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026393	VEGA Gene Model | MGI Sequence Detail	19747	C57BL/6J
transcript	OTTMUST00000065269	VEGA | MGI Sequence Detail	4798	Not Applicable
polypeptide	OTTMUSP00000032506	VEGA | MGI Sequence Detail	413	Not Applicable

All sequences(23) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(113 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003780	Heme A synthase
InterPro	IPR023754	Heme A synthase, type 2
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
Protein Ontology	PR:000005771	cytochrome c oxidase assembly protein COX15

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:176080 Viscomi C, et al., In vivo correction of COX deficiency by activation of the AMPK/PGC-1alpha axis. Cell Metab. 2011 Jul 6;14(1):80-90
All references(32)