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Cox15
Gene Detail
Symbol

Name
ID
Cox15
cytochrome c oxidase assembly protein 15
MGI:1920112
Synonyms
2900026G05Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 19
36.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:43733254-43753000 bp, - strand
From VEGA annotation of GRCm38

  19747 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5848  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: COX15
Gene Tree: Cox15

Human
homologs
COX15, cytochrome c oxidase assembly homolog 15 (yeast)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1355
neXtProt AC: NX_Q7KZN9

Human Synonyms: CEMCOX2

Human Chr (Location): 10q24; chr10:99696129-99732666 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human COX15

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit embryonic lethality.
 
Interactions
Cox15 interacts with 328 markers (Mir7-1, Mir10a, Mir10b, ...)
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100486044 ; ZFIN cox15    NEW 
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000026393 (Evidence)
Ensembl Gene Model ENSMUSG00000040018 (Evidence)
Entrez Gene 226139 (Evidence)
Consensus CDS Project CCDS29836.1
International Mouse Phenotyping Consortium Status Cox15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026393 VEGA Gene Model | MGI Sequence Detail 19747 C57BL/6J ±  kb
transcript OTTMUST00000065269 VEGA | MGI Sequence Detail 4798 Not Applicable 
polypeptide OTTMUSP00000032506 VEGA | MGI Sequence Detail 413 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(141 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003780 Heme A synthase
InterPro IPR023754 Heme A synthase, type 2
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000005771 cytochrome c oxidase assembly protein COX15
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:176080 Viscomi C, et al., In vivo correction of COX deficiency by activation of the AMPK/PGC-1alpha axis. Cell Metab. 2011 Jul 6;14(1):80-90
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory