Cox15 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cox15
cytochrome c oxidase assembly protein 15
MGI:1920112

19 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
\Cox15^m1Mhda/\Cox15^m1Mhda C3HeB/FeJ-Cox15^m1Mhda	no abnormal phenotype detected	J:82809
\Cox15^{tm1.1(KOMP)Vlcg}/\Cox15⁺ C57BL/6N-Cox15^{tm1.1(KOMP)Vlcg}/Ucd	abnormal heart morphology	J:211773
	increased circulating alanine transaminase level	J:211773
	increased circulating aspartate transaminase level	J:211773
	increased heart atrium size	J:211773
	increased heart weight	J:211773
\Cox15^{tm1.1(KOMP)Vlcg}/\Cox15^{tm1.1(KOMP)Vlcg} C57BL/6N-Cox15^{tm1.1(KOMP)Vlcg}/MbpMmucd	embryonic lethality prior to organogenesis	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
\Cox15^{tm1.1(KOMP)Vlcg}/\Cox15^{tm1.1(KOMP)Vlcg} C57BL/6N-Cox15^{tm1.1(KOMP)Vlcg}/Ucd	preweaning lethality, complete penetrance	J:211773
\Cox15^tm1.1Zev/\Cox15^tm1.1Zev \Tg(ACTA1-cre)79Jme/0 involves: 129 * C57BL/6 * C57BL/6J * SJL	abnormal cellular respiration	J:176080
	abnormal motor capabilities/coordination/movement	J:176080
	abnormal muscle fiber mitochondrial morphology	J:176080
	centrally nucleated skeletal muscle fibers	J:176080
	increased mitochondrial fission	J:176080
	increased physiological sensitivity to xenobiotic	J:176080
	increased susceptibility to xenobiotic induced morbidity/mortality	J:176080
	increased variability of skeletal muscle fiber size	J:176080
	myopathy	J:176080
\Cox15^tm1.2Zev/\Cox15^tm1.2Zev involves: 129 * C57BL/6	embryonic lethality, complete penetrance	J:176080

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