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Pot1b
Gene Detail
Symbol

Name
ID
Pot1b
protection of telomeres 1B
MGI:1920086
Synonyms
2810458H16Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 17
28.93 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:55652025-55712628 bp, - strand
From Ensembl annotation of GRCm38

  60604 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(6) Targeted(6) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for one null mutation display male infertility with age, male germ cell apoptosis, hyperpigmentation, increased apoptosis in intestinal crypts, and decreased body size. Mice homozygous for a transgenic gene disruption exhibit neonatal lethality with possible stem cell defects.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Pot1b interacts with 234 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cell aging, chromosome organization, ...
Component nuclear chromosome, telomeric region, nuclear telomere cap complex
Function protein binding, Rab GTPase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (24)    Tissues (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 24
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(5) Primer pair(2)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000024174 (Evidence)
Entrez Gene 72836 (Evidence)
DFCI TC1617647, TC1589284, TC1592310
DoTS DT.40182146, DT.55233506, DT.91288243, DT.91326405
NIA Mouse Gene Index U037930
Consensus CDS Project CCDS50147.1
International Mouse Phenotyping Consortium Status Pot1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024174 Ensembl Gene Model | MGI Sequence Detail 60604 C57BL/6J ±  kb
transcript ENSMUST00000086876 Ensembl | MGI Sequence Detail 3499 Not Applicable 
polypeptide ENSMUSP00000084089 Ensembl | MGI Sequence Detail 640 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(30) UniProt(2)
Polymorphisms
SNPs within 2kb(607 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012340 Nucleic acid-binding, OB-fold
InterPro IPR011564 Telomere end binding protein
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:213522 Frescas D, et al., TRF2-tethered TIN2 can mediate telomere protection by TPP1/POT1. Mol Cell Biol. 2014 Apr;34(7):1349-62
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory