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Tdp1 Gene Detail
Summary
  • Symbol
    Tdp1
  • Name
    tyrosyl-DNA phosphodiesterase 1
  • Synonyms
    2810481F14Rik, 4921509N21Rik, E430034L06Rik, SCAN1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920036
    NCBI Gene: 104884
  • Gene Overview
    MyGene.info: TDP1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:99884517-99955219 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 50.43 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    705 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920036
protein coding gene Chr12:99884515-99955219 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020013
protein coding gene Chr12:101336864-101408330 (+)
A/J MGP_AJ_G0019968
protein coding gene Chr12:97531300-97601762 (+)
AKR/J MGP_AKRJ_G0019944
protein coding gene Chr12:100160646-100233626 (+)
BALB/cJ MGP_BALBcJ_G0019954
protein coding gene Chr12:97869649-97940891 (+)
C3H/HeJ MGP_C3HHeJ_G0019756
protein coding gene Chr12:100701708-100774486 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020403
protein coding gene Chr12:104455006-104527468 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018017
protein coding gene Chr12:94498861-94566897 (+)
CAST/EiJ MGP_CASTEiJ_G0019302
protein coding gene Chr12:95799799-95882225 (+)
CBA/J MGP_CBAJ_G0019728
protein coding gene Chr12:108331619-108412579 (+)
DBA/2J MGP_DBA2J_G0019839
protein coding gene Chr12:96962231-97033320 (+)
FVB/NJ MGP_FVBNJ_G0019828
protein coding gene Chr12:95676858-95747313 (+)
LP/J MGP_LPJ_G0019915
protein coding gene Chr12:101163056-101236711 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019870
protein coding gene Chr12:111948800-112021448 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020432
protein coding gene Chr12:99725463-99799482 (+)
PWK/PhJ MGP_PWKPhJ_G0019066
protein coding gene Chr12:91589625-91660407 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018862
protein coding gene Chr12:93902822-93977899 (+)
WSB/EiJ MGP_WSBEiJ_G0019356
protein coding gene Chr12:100581998-100655192 (+)



Homology
more
  • Human Ortholog
    TDP1, tyrosyl-DNA phosphodiesterase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TDP1, tyrosyl-DNA phosphodiesterase 1
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 55775
    neXtProt AC: NX_Q9NUW8
    UniProt: Q9NUW8

  • Chr Location
    14q32.11; chr14:89954935-90044764 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 5424
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TDP1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Tdp1 mouse models; 1 with human TDP1 associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 3 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit defective single strand DNA repair in neurons, decreased cerebellum size and increased sensitivity to topotecan.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021177 Ensembl Gene Model | MGI Sequence Detail 70703 C57BL/6J ±  kb
transcript ENSMUST00000153627 Ensembl | MGI Sequence Detail 2036 Not Applicable  
polypeptide ENSMUSP00000118656 Ensembl | MGI Sequence Detail 609 Not Applicable  
For the selected sequence
Molecular
Reagents
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  • All nucleic 8
    cDNA 8

    Microarray probesets 3
Other
Accession IDs
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MGI:1918105, MGI:2144890, MGI:2145029, MGI:3041233
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Diseases 2
    Gene Ontology 5
    Phenotypes 19
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:262613 Fam HK, et al., Reactive oxygen species stress increases accumulation of tyrosyl-DNA phsosphodiesterase 1 within mitochondria. Sci Rep. 2018 Mar 9;8(1):4304

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory