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Tdp1
Gene Detail
 Symbol
Name
ID
Tdp1
tyrosyl-DNA phosphodiesterase 1
MGI:1920036
Synonyms 2810481F14Rik, 4921509N21Rik, E430034L06Rik, SCAN1
Feature Type protein coding gene
Genetic Map
Chromosome 12
50.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:99884517-99955219 bp, + strand
From VEGA annotation of GRCm38

  70703 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5424  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tdp1

Human
homologs
Human Homolog TDP1, tyrosyl-DNA phosphodiesterase 1
NCBI Gene ID 55775
neXtProt AC  NX_Q9NUW8
Human Chr (Location)  14q32.11; chr14:89955600-90044764 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TDP1
Alleles
and
phenotypes
All alleles(21) : Targeted(3) Gene trapped(18)
 
Mice homozygous for a null allele exhibit defective single strand DNA repair in neurons, decreased cerebellum size and increased sensitivity to topotecan.
 
Human Diseases Modeled Using Mouse Tdp1 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cellular response to DNA damage stimulus, DNA repair, ...
Component nucleus
Function 3'-tyrosyl-DNA phosphodiesterase activity, double-stranded DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000033586 (Evidence)
Ensembl Gene ModelENSMUSG00000021177 (Evidence)
Entrez Gene104884 (Evidence)
DFCITC1577646, TC1594143, TC1595117, TC1613323, TC1747791
DoTSDT.101384379, DT.101384380, DT.91435075, DT.91439260, DT.97335438, DT.99847475
NIA Mouse Gene IndexU014274, U014276, U265881
EC3.1.4.-
Consensus CDS ProjectCCDS26105.2
International Mouse Knockout Project StatusTdp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033586 VEGA Gene Model | MGI Sequence Detail 70703 C57BL/6J ±  kb
transcript OTTMUST00000084599 VEGA | MGI Sequence Detail 2036 Not Applicable 
polypeptide OTTMUSP00000045614 VEGA | MGI Sequence Detail 609 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(12) UniProt(5)
Polymorphisms SNPs within 2kb(705 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010347 Tyrosyl-DNA phosphodiesterase
InterPro IPR027415 Tyrosyl-DNA phosphodiesterase C-terminal domain
Protein Ontology PR:000016215 tyrosyl-DNA phosphodiesterase 1
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:200260 Prasad R, et al., Pol beta associated complex and base excision repair factors in mouse fibroblasts. Nucleic Acids Res. 2012 Dec;40(22):11571-82
All references(41)
Other
accession IDs
MGI:1918105, MGI:2144890, MGI:2145029, MGI:3041233

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory