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Tdp1
Gene Detail
Symbol

Name
ID
Tdp1
tyrosyl-DNA phosphodiesterase 1
MGI:1920036
Synonyms
2810481F14Rik, 4921509N21Rik, E430034L06Rik, SCAN1
Feature Type
protein coding gene
Genetic Map
Chromosome 12
50.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:99884517-99955219 bp, + strand
From VEGA annotation of GRCm38

  70703 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5424  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TDP1
Gene Tree: Tdp1

Human
homologs
TDP1, tyrosyl-DNA phosphodiesterase 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 55775
neXtProt AC: NX_Q9NUW8

Human Chr (Location): 14q32.11; chr14:89954935-90044764 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TDP1

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(6) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit defective single strand DNA repair in neurons, decreased cerebellum size and increased sensitivity to topotecan.
 
Human Diseases Modeled in Mice Using Tdp1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Tdp1 interacts with 64 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tdp1    NEW 
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000033586 (Evidence)
Ensembl Gene Model ENSMUSG00000021177 (Evidence)
Entrez Gene 104884 (Evidence)
DFCI TC1594143, TC1747791, TC1613323, TC1577646, TC1595117
DoTS DT.101384379, DT.101384380, DT.99847475, DT.91435075, DT.97335438, DT.91439260
NIA Mouse Gene Index U265881, U014276, U014274
EC 3.1.4.-
Consensus CDS Project CCDS26105.2
International Mouse Phenotyping Consortium Status Tdp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033586 VEGA Gene Model | MGI Sequence Detail 70703 C57BL/6J ±  kb
transcript OTTMUST00000084599 VEGA | MGI Sequence Detail 2036 Not Applicable 
polypeptide OTTMUSP00000045614 VEGA | MGI Sequence Detail 609 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(705 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010347 Tyrosyl-DNA phosphodiesterase
InterPro IPR027415 Tyrosyl-DNA phosphodiesterase C-terminal domain
Protein Ontology PR:000016215 tyrosyl-DNA phosphodiesterase 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:215106 Yeo AJ, et al., R-loops in proliferating cells but not in the brain: implications for AOA2 and other autosomal recessive ataxias. PLoS One. 2014;9(3):e90219
All references(41)
Disease annotation references (2)
Other
accession IDs
MGI:1918105, MGI:2144890, MGI:2145029, MGI:3041233

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory