Tdp1
Gene Detail

Symbol Name ID

Tdp1 tyrosyl-DNA phosphodiesterase 1 MGI:1920036

Synonyms

2810481F14Rik, 4921509N21Rik, E430034L06Rik, SCAN1

Feature Type

protein coding gene

Genetic Map

Chromosome 12

50.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr12:99884517-99955219 bp, + strand From VEGA annotation of GRCm38   70703 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5424  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tdp1

Human homologs

Human Homolog		TDP1, tyrosyl-DNA phosphodiesterase 1
NCBI Gene ID		55775
neXtProt AC		NX_Q9NUW8
Human Chr (Location)		14q32.11; chr14:90422246-90511108 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TDP1

Alleles and phenotypes

All alleles(21) : Targeted(3) Gene trapped(18)
 

Mice homozygous for a null allele exhibit defective single strand DNA repair in neurons, decreased cerebellum size and increased sensitivity to topotecan.

 
Human Diseases Modeled Using Mouse Tdp1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	DNA repair, double-strand break repair, ...
Component	nucleus
Function	3'-tyrosyl-DNA phosphodiesterase activity, double-stranded DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(52)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(52) cDNA(52)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000033586 (Evidence)
Ensembl Gene Model	ENSMUSG00000021177 (Evidence)
Entrez Gene	104884 (Evidence)
UniGene	312323
DFCI	TC1577646, TC1594143, TC1595117, TC1613323, TC1747791
DoTS	DT.101384379, DT.101384380, DT.91435075, DT.91439260, DT.97335438, DT.99847475
NIA Mouse Gene Index	U014274, U014276, U265881
EC	3.1.4.-
Consensus CDS Project	CCDS26105.2
International Mouse Knockout Project Status	Tdp1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033586	VEGA Gene Model | MGI Sequence Detail	70703	C57BL/6J
transcript	OTTMUST00000084599	VEGA | MGI Sequence Detail	2036	Not Applicable
polypeptide	OTTMUSP00000045614	VEGA | MGI Sequence Detail	609	Not Applicable

All sequences(56) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(443 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR010347	Tyrosyl-DNA phosphodiesterase
Protein Ontology	PR:000016215	tyrosyl-DNA phosphodiesterase 1

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:170077 Gao Y, et al., DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair. Nature. 2011 Mar 10;471(7337):240-4
All references(40)

Other accession IDs

MGI:1918105, MGI:2144890, MGI:2145029, MGI:3041233