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Tonsl Gene Detail
Summary
  • Symbol
    Tonsl
  • Name
    tonsoku-like, DNA repair protein
  • Synonyms
    2810439M11Rik, Nfkbil2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919999
    NCBI Gene: 72749
  • Gene Overview
    MyGene.info: TONSL
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:76626237-76639929 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 36.18 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    109 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919999
protein coding gene Chr15:76626002-76639958 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022002
protein coding gene Chr15:76711412-76731135 (-)
A/J MGP_AJ_G0021960
protein coding gene Chr15:73907752-73927477 (-)
AKR/J MGP_AKRJ_G0021943
protein coding gene Chr15:75916439-75934282 (-)
BALB/cJ MGP_BALBcJ_G0021969
protein coding gene Chr15:73934048-73952831 (-)
C3H/HeJ MGP_C3HHeJ_G0021741
protein coding gene Chr15:75961441-75979240 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022409
protein coding gene Chr15:79574874-79592577 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019938
protein coding gene Chr15:70565607-70583380 (-)
CAST/EiJ MGP_CASTEiJ_G0021260
protein coding gene Chr15:76765195-76783239 (-)
CBA/J MGP_CBAJ_G0021708
protein coding gene Chr15:82093681-82112833 (-)
DBA/2J MGP_DBA2J_G0021833
protein coding gene Chr15:73446354-73464250 (-)
FVB/NJ MGP_FVBNJ_G0021813
protein coding gene Chr15:72502635-72520691 (-)
LP/J MGP_LPJ_G0021904
protein coding gene Chr15:76800683-76821171 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021838
protein coding gene Chr15:87433174-87452188 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022429
protein coding gene Chr15:76190158-76208021 (-)
PWK/PhJ MGP_PWKPhJ_G0021001
protein coding gene Chr15:73610420-73628311 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020841
protein coding gene Chr15:75882817-75900674 (-)
WSB/EiJ MGP_WSBEiJ_G0021312
protein coding gene Chr15:76277095-76295976 (-)



Homology
more
  • Human Ortholog
    TONSL, tonsoku like, DNA repair protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TONSL, tonsoku like, DNA repair protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IKBR, NFKBIL2
  • Links
    NCBI Gene ID: 4796
    neXtProt AC: NX_Q96HA7
    UniProt: Q96HA7

  • Chr Location
    8q24.3; chr8:144428780-144444488 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 72749 NCBI Gene Model | MGI Sequence Detail 13693 C57BL/6J ±  kb
transcript NM_183091 RefSeq | MGI Sequence Detail 4239 C57BL/6  
polypeptide Q6NZL6 UniProt | EBI | MGI Sequence Detail 1363 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR020683 Ankyrin repeat-containing domain
    IPR036770 Ankyrin repeat-containing domain superfamily
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain superfamily
    IPR011990 Tetratricopeptide-like helical domain superfamily
    IPR019734 Tetratricopeptide repeat
    IPR013026 Tetratricopeptide repeat-containing domain
Molecular
Reagents
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  • All nucleic 34
    cDNA 34

    Microarray probesets 3
References
more
  • Summaries
    All 47
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 2
    Phenotypes 27
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:233611 Hirata A, et al., Homeobox family Hoxc localization during murine palate formation. Congenit Anom (Kyoto). 2016 Jul;56(4):172-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory