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Auts2 Gene Detail
Summary
  • Symbol
    Auts2
  • Name
    autism susceptibility candidate 2
  • Synonyms
    2700063G02Rik, A730011F23Rik, D830032G16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919847
    NCBI Gene: 319974
  • Alliance
    genome feature page
  • Transcription Start Sites
    37 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:131466171-132572059 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 70.66 cM, cytoband G1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    31386 from dbSNP Build 142
  • Strain Annotations
    25
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919847
 protein coding gene Chr5:131466171-132572183 (-)
129S1/SvImJ ENSMUSGG00200054915
 protein coding gene Chr5:125833571-126241817 (-)
129S1/SvImJ ENSMUSG00200045655
 protein coding gene Chr5:125239952-125277349 (-)
A/J ENSMUSGG00195055026
 protein coding gene Chr5:125349313-125760664 (-)
A/J ENSMUSG00195049511
 protein coding gene Chr5:124755640-124793036 (-)
AKR/J ENSMUSG00220044325
 protein coding gene Chr5:124224064-124261177 (-)
AKR/J ENSMUSGG00220054444
 protein coding gene Chr5:124817452-125235840 (-)
BALB/cJ ENSMUSGG00180055159
 protein coding gene Chr5:125456542-125867890 (-)
BALB/cJ ENSMUSG00180033628
 protein coding gene Chr5:124862891-124900287 (-)
C3H/HeJ ENSMUSG00175039512
 protein coding gene Chr5:126823151-126860542 (-)
C57BL/6NJ ENSMUSGG00215055736
 protein coding gene Chr5:125489720-125908154 (-)
C57BL/6NJ ENSMUSG00215044529
 protein coding gene Chr5:124896079-124933468 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027805
 protein coding gene Chr5:124280424-125380513 (-)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054690
 protein coding gene Chr5:126174403-126582629 (-)
CBA/J ENSMUSG00210005946
 protein coding gene Chr5:125580797-125618189 (-)
DBA/2J ENSMUSG00185007560
 protein coding gene Chr5:128626087-128663479 (-)
DBA/2J ENSMUSGG00185057832
 protein coding gene Chr5:129219699-129627938 (-)
FVB/NJ ENSMUSGG00205054131
 protein coding gene Chr5:125121231-125532454 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230047285
 protein coding gene Chr5:132737613-132775003 (-)
LP/J ENSMUSGG00230055849
 protein coding gene Chr5:133331199-133742517 (-)
NOD/ShiLtJ ENSMUSGG00190054645
 protein coding gene Chr5:125151703-125559568 (-)
NOD/ShiLtJ ENSMUSG00190030565
 protein coding gene Chr5:124555639-124593130 (-)
NZO/HlLtJ ENSMUSG00225013510
 protein coding gene Chr5:140426488-140464925 (-)
NZO/HlLtJ ENSMUSGG00225055277
 protein coding gene Chr5:141017423-141422746 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010026855
 protein coding gene Chr5:126825536-127926428 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    AUTS2, activator of transcription and developmental regulator AUTS2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AUTS2, activator of transcription and developmental regulator AUTS2
  • Synonyms
    FBRSL2, MRD26
  • Links
    NCBI Gene ID: 26053
    UniProt: Q8WXX7

  • Chr Location
    7q11.22; chr7:69598296-70793506 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Auts2 mouse models; 1 with human AUTS2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 5 alleles in 4 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a brain-specific knockout are smaller than controls, and exhibit behavioral defects such as less vocalizations, impairments in righting response and geotaxis, and decreased food intake.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    839
  • Tissues
    180
  • cDNA Data
    29
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      97
    • RefSeq
      2
    • UniProt
      12
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 319974 NCBI Gene Model | MGI Sequence Detail 1105889 C57BL/6J ±  kb
    transcript NM_001363480 RefSeq | MGI Sequence Detail 7291 Not Specified  
    polypeptide A0A087WPF7 UniProt | EBI | MGI Sequence Detail 1261 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 30
      Other 2
      Antibodies 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2442710, MGI:2443091
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 19
      Diseases 2
      Gene Ontology 8
      Phenotypes 22
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:362390 Shimaoka K, et al., The microcephaly-associated transcriptional regulator AUTS2 cooperates with Polycomb complex PRC2 to produce upper-layer neurons in mice. EMBO J. 2025 Mar;44(5):1354-1378
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory