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Uaca Gene Detail
Summary
  • Symbol
    Uaca
  • Name
    uveal autoantigen with coiled-coil domains and ankyrin repeats
  • Synonyms
    2700059D02Rik, nucling
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919815
    NCBI Gene: 72565
  • Gene Overview
    MyGene.info: UACA
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:60794542-60880370 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      85829 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 32.93 cM, cytoband C
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    UACA, uveal autoantigen with coiled-coil domains and ankyrin repeats
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UACA, uveal autoantigen with coiled-coil domains and ankyrin repeats
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NUCLING
  • Links
    NCBI Gene ID: 55075
    neXtProt AC: NX_Q9BZF9
    UniProt: Q9BZF9

  • Chr Location
    15q23; chr15:70654554-70778823 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 74297
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: UACA
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Uaca mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice display swelling of and inflammatory lesions in the preputial gland.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034485 Ensembl Gene Model | MGI Sequence Detail 85829 C57BL/6J ±  kb
    transcript ENSMUST00000050183 Ensembl | MGI Sequence Detail 4428 Not Applicable  
    polypeptide ENSMUSP00000062047 Ensembl | MGI Sequence Detail 1413 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      617 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR020683 Ankyrin repeat-containing domain
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR030227 Protein Nucling
      IPR000727 Target SNARE coiled-coil homology domain
    Molecular
    Reagents
    less
    • All nucleic 87
      cDNA 87

      Microarray probesets 5
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:244571 Kim SM, et al., Nucling, a novel protein associated with NF-kappaB, regulates endotoxin-induced apoptosis in vivo. J Biochem. 2013 Jan;153(1):93-101

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.
    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory