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Uaca
Gene Detail
 Symbol
Name
ID
Uaca
uveal autoantigen with coiled-coil domains and ankyrin repeats
MGI:1919815
Synonyms 2700059D02Rik, nucling
Feature Type protein coding gene
Genetic Map
Chromosome 9
32.93 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:60794548-60880370 bp, + strand
From NCBI annotation of GRCm38

  85823 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74297  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Uaca

Human
homologs
Human Homolog UACA, uveal autoantigen with coiled-coil domains and ankyrin repeats
NCBI Gene ID 55075
neXtProt AC  NX_Q9BZF9
Human Synonyms  NUCLING
Human Chr (Location)  15q22-q24; chr15:70654554-70763593 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(12) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice display swelling of and inflammatory lesions in the preputial gland.
 
Human Diseases Modeled Using Mouse Uaca (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Uaca interacts with 53 markers (Mir7-2, Mir7b, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process intrinsic apoptotic signaling pathway in response to DNA damage, intrinsic apoptotic signaling pathway in response to oxidative stress, ...
Component apoptosome, cytoplasm, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (15)    Tissues (15)    Images (1)
Theiler Stages: 10, 15, 17, 18, 22, 23, 25, 28
Assay TypeResults
RNA in situ 3
Northern blot 12
cDNA source data(87)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(87) cDNA(87)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000034485 (Evidence)
Entrez Gene72565 (Evidence)
UniGene68819
DFCITC1577513, TC1591662
DoTSDT.103560283, DT.490153, DT.55157941, DT.97365079
NIA Mouse Gene IndexU010589
Consensus CDS ProjectCCDS23259.1
International Mouse Knockout Project StatusUaca
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 72565 NCBI Gene Model | MGI Sequence Detail 85823 C57BL/6J ±  kb
transcript NM_028283 RefSeq | MGI Sequence Detail 4428 C57BL/6 
polypeptide Q8CGB3 UniProt | EBI | MGI Sequence Detail 1411 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(10) UniProt(2)
Polymorphisms SNPs within 2kb(614 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR000727 Target SNARE coiled-coil domain
Protein Ontology PR:000016947 uveal autoantigen with coiled-coil domains and ankyrin repeats
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:157049 Sakai T, et al., Inflammatory disease and cancer with a decrease in Kupffer cell numbers in Nucling-knockout mice. Int J Cancer. 2010 Mar 1;126(5):1079-94
All references(38)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory