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Tmem173 Gene Detail
Summary
  • Symbol
    Tmem173
  • Name
    transmembrane protein 173
  • Synonyms
    2610307O08Rik, ERIS, MPYS, Sting
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919762
    NCBI Gene: 72512
  • Gene Overview
    MyGene.info: TMEM173
Location & Maps
more
  • Sequence Map
    Chr18:35733678-35740554 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6877 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TMEM173, transmembrane protein 173
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TMEM173, transmembrane protein 173
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ERIS, hMITA, hSTING, MITA, MPYS, NET23, SAVI, STING
  • Links
    NCBI Gene ID: 340061
    neXtProt AC: NX_Q86WV6

  • Chr Location
    5q31.2; chr5:139475528-139482790 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TMEM173 associations

Human Disease Mouse Models
       Sting-Associated Vasculopathy, Infantile-Onset; SAVI   OMIM: 615934
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (ENU)
    1
  • Targeted
    7
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit increased susceptibility to viral infection and abnormal innate immunity. Mice homozygous for an ENU-induced allele exhibit altered response to bacterial and viral infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 72512 NCBI Gene Model | MGI Sequence Detail 6877 C57BL/6J ±  kb
transcript NM_028261 RefSeq | MGI Sequence Detail 2302 C57BL/6  
polypeptide Q3TBT3 UniProt | EBI | MGI Sequence Detail 378 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    27 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 43
    cDNA 43

    Microarray probesets 5
References
more
  • Summaries
    All 83
    Developmental Gene Expression 1
    Gene Ontology 14
    Phenotypes 43
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:228986 Temizoz B, et al., TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN. Eur J Immunol. 2015 Apr;45(4):1159-69

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory