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Tmem173 Gene Detail
Summary
  • Symbol
    Tmem173
  • Name
    transmembrane protein 173
  • Synonyms
    2610307O08Rik, ERIS, MPYS, Sting
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919762
    NCBI Gene: 72512
  • Gene Overview
    MyGene.info: TMEM173
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:35733678-35740554 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 19.23 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    27 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919762
protein coding gene Chr18:35733678-35740554 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024270
protein coding gene Chr18:34065100-34071974 (-)
A/J MGP_AJ_G0024236
protein coding gene Chr18:32887525-32894401 (-)
AKR/J MGP_AKRJ_G0024204
protein coding gene Chr18:33821674-33828550 (-)
BALB/cJ MGP_BALBcJ_G0024236
protein coding gene Chr18:32932480-32939356 (-)
C3H/HeJ MGP_C3HHeJ_G0024003
protein coding gene Chr18:33852529-33860028 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024677
protein coding gene Chr18:35285057-35291933 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022117
protein coding gene Chr18:32993047-32998907 (-)
CAST/EiJ MGP_CASTEiJ_G0023478
protein coding gene Chr18:33830089-33837091 (-)
CBA/J MGP_CBAJ_G0023971
protein coding gene Chr18:36312670-36319546 (-)
DBA/2J MGP_DBA2J_G0024103
protein coding gene Chr18:32522037-32528903 (-)
FVB/NJ MGP_FVBNJ_G0024070
protein coding gene Chr18:32211456-32219739 (-)
LP/J MGP_LPJ_G0024185
protein coding gene Chr18:34118028-34124904 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024098
protein coding gene Chr18:37531592-37538560 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024726
protein coding gene Chr18:33654464-33661340 (-)
PWK/PhJ MGP_PWKPhJ_G0023222
protein coding gene Chr18:32747702-32757546 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023029
protein coding gene Chr18:33924214-33930613 (-)
WSB/EiJ MGP_WSBEiJ_G0023541
protein coding gene Chr18:33585140-33592016 (-)



Homology
more
  • Human Ortholog
    TMEM173, transmembrane protein 173
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TMEM173, transmembrane protein 173
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ERIS, hMITA, hSTING, MITA, MPYS, NET23, SAVI, STING, STING-beta
  • Links
    NCBI Gene ID: 340061
    neXtProt AC: NX_Q86WV6
    UniProt: Q86WV6

  • Chr Location
    5q31.2; chr5:139475528-139482790 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    103 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to viral infection and abnormal innate immunity. Mice homozygous for an ENU-induced allele exhibit altered response to bacterial and viral infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 72512 NCBI Gene Model | MGI Sequence Detail 6877 C57BL/6J ±  kb
transcript NM_028261 RefSeq | MGI Sequence Detail 2302 C57BL/6  
polypeptide Q3TBT3 UniProt | EBI | MGI Sequence Detail 378 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 44
    cDNA 44

    Microarray probesets 5
References
more
  • Summaries
    All 179
    Developmental Gene Expression 1
    Gene Ontology 20
    Phenotypes 103
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:266322 Torralba D, et al., Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts. Nat Commun. 2018 Jul 9;9(1):2658

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory