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Tmem173
Gene Detail
Symbol

Name
ID
Tmem173
transmembrane protein 173
MGI:1919762
Synonyms
2610307O08Rik, ERIS, MPYS, Sting
Feature Type
protein coding gene
Genetic Map
Chromosome 18
19.23 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:35733678-35740554 bp, - strand
From NCBI annotation of GRCm38

  6877 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18868  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TMEM173
Gene Tree: Tmem173

Human
homologs
TMEM173, transmembrane protein 173
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 340061
neXtProt AC: NX_Q86WV6

Human Synonyms: ERIS, hMITA, hSTING, MITA, MPYS, NET23, SAVI, STING

Human Chr (Location): 5q31.2; chr5:139475528-139482790 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TMEM173

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased susceptibility to viral infection and abnormal innate immunity. Mice homozygous for an ENU-induced allele exhibit altered response to bacterial and viral infection.
 
Interactions
Tmem173 interacts with 130 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process activation of innate immune response, apoptotic process, ...
Component cytoplasm, endoplasmic reticulum, ...
Function cyclic-di-GMP binding, cyclic-GMP-AMP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(43)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tmem173    NEW 
Molecular
reagents
All nucleic(43) cDNA(43)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000024349 (Evidence)
Entrez Gene 72512 (Evidence)
UniGene 45995
DFCI TC1575050
DoTS DT.94128630, DT.99862930
NIA Mouse Gene Index U041219
PDB 4JC5, 4KBY, 4KC0, 4LOJ, 4LOK, 4LOL
Consensus CDS Project CCDS50253.1
International Mouse Phenotyping Consortium Status Tmem173
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 72512 NCBI Gene Model | MGI Sequence Detail 6877 C57BL/6J ±  kb
transcript NM_028261 RefSeq | MGI Sequence Detail 2302 C57BL/6 
polypeptide Q3TBT3 UniProt | EBI | MGI Sequence Detail 378 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(27 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR029158 Stimulator of interferon genes protein
Protein Ontology PR:000016417 transmembrane protein 173
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:220964 Wang J, et al., Effective and lesion-free cutaneous influenza vaccination. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5005-10
All references(78)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory