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Tmem173
Gene Detail
 Symbol
Name
ID
Tmem173
transmembrane protein 173
MGI:1919762
Synonyms 2610307O08Rik, ERIS, MPYS, Sting
Feature Type protein coding gene
Genetic Map
Chromosome 18
19.23 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:35733678-35740554 bp, - strand
From NCBI annotation of GRCm38

  6877 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18868  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tmem173

Human
homologs
Human Homolog TMEM173, transmembrane protein 173
NCBI Gene ID 340061
neXtProt AC  NX_Q86WV6
Human Synonyms  ERIS, MITA, MPYS, NET23, SAVI, STING
Human Chr (Location)  5q31.2; chr5:139475528-139482758 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TMEM173
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased susceptibility to viral infection and abnormal innate immunity. Mice homozygous for an ENU-induced allele exhibit altered response to bacterial and viral infection.
 
Interactions
Tmem173 interacts with 130 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process activation of innate immune response, apoptotic process, ...
Component cytoplasm, endoplasmic reticulum, ...
Function cyclic-di-GMP binding, cyclic-GMP-AMP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(43)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) cDNA(43)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000024349 (Evidence)
Entrez Gene72512 (Evidence)
UniGene45995
DFCITC1575050
DoTSDT.94128630, DT.99862930
NIA Mouse Gene IndexU041219
PDB4KBY, 4LOJ, 4LOK, 4LOL, 4JC5, 4KC0
Consensus CDS ProjectCCDS50253.1
International Mouse Knockout Project StatusTmem173
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 72512 NCBI Gene Model | MGI Sequence Detail 6877 C57BL/6J ±  kb
transcript NM_028261 RefSeq | MGI Sequence Detail 2302 C57BL/6 
polypeptide Q3TBT3 UniProt | EBI | MGI Sequence Detail 378 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(8) UniProt(1)
Polymorphisms SNPs within 2kb(27 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000016417 transmembrane protein 173
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:209981 Zang Y, et al., Conservation of pathogenic TCR homology across class II restrictions in anti-ribonucleoprotein autoimmunity: extended efficacy of T cell vaccine therapy. J Immunol. 2014 May 1;192(9):4093-102
All references(72)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory