Sting1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sting1
stimulator of interferon response cGAMP interactor 1
MGI:1919762

40 phenotypes from 6 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
\Sting1^em1Jmin/\Sting1⁺ involves: C57BL/6N	abnormal cytokine level	J:251372
	abnormal lung thrombosis	J:251372
	abnormal spleen morphology	J:251372
	decreased single-positive T cell number	J:251372
	enlarged spleen	J:251372
	increased circulating interleukin-10 level	J:251372
	increased circulating interleukin-13 level	J:251372
	increased circulating tumor necrosis factor level	J:251372
	increased IgM level	J:251372
	increased myeloid cell number	J:251372
	lung inflammation	J:251372
	pleural effusion	J:251372
	normal renal/urinary system phenotype	J:251372
	respiratory distress	J:251372
	skin lesions	J:251372
	spontaneous skin ulceration	J:251372
\Sting1^em1Jmin/\Sting1^em1Jmin involves: C57BL/6N	prenatal lethality, complete penetrance	J:251372
\Sting1^em1Osb/\Sting1^em1Osb involves: C57BL/6NJcl * DBA/2NJcl	reproductive system phenotype	J:348425
\Sting1^gt/\Sting1^gt C57BL/6-Sting1^gt	abnormal dendritic cell physiology	J:201167
	abnormal humoral immune response	J:201167
	abnormal immune cell physiology	J:201167
	abnormal macrophage physiology	J:201167
	abnormal plasmacytoid dendritic cell physiology	J:201167
	abnormal response to infection	J:168746
	decreased circulating interferon-alpha level	J:201167
	decreased circulating interferon-beta level	J:168746, J:201167
	increased susceptibility to Herpesvirales infection	J:201167
	increased susceptibility to Herpesvirales infection induced morbidity/mortality	J:201167
\Sting1^gt/\Sting1^gt C57BL/6J-Sting1^gt/J	abnormal interferon-beta secretion	J:354143
	abnormal level of surface class I molecules	J:363611
	abnormal MHC II cell surface expression on macrophages	J:363611
	abnormal response to infection	J:354143
	increased susceptibility to Retroviridae infection	J:354143
\Sting1^gt/\Sting1^gt involves: C57BL/6	decreased enterocyte apoptosis	J:269933
	normal hematopoietic system phenotype	J:265023
	normal immune system phenotype	J:265023
	increased susceptibility to Retroviridae infection	J:265023
\Sting1^{tm1.1(KOMP)Mbp}/\Sting1^{tm1.1(KOMP)Mbp} C57BL/6NCrl-Sting1^{tm1.1(KOMP)Mbp}/MbpMmucd	female infertility	J:211773
\Sting1^tm1Camb/\Sting1^tm1Camb involves: C57BL/6N	decreased circulating interferon-beta level	J:179270
	decreased circulating interleukin-6 level	J:179270
	normal immune system phenotype	J:179270
\Sting1^tm1Gnb/\Sting1^tm1Gnb involves: 129P2/OlaHsd	abnormal response to infection	J:168746
\Sting1^tm1Gnb/\Sting1^tm1Gnb involves: 129P2/OlaHsd * C57BL/6	abnormal innate immunity	J:141011
	abnormal susceptibility to Herpesvirales infection	J:141011
	increased susceptibility to Riboviria infection	J:141011

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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