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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Sting1
stimulator of interferon response cGAMP interactor 1
MGI:1919762
40 phenotypes from 6 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
\Sting1em1Jmin/\Sting1+
involves: C57BL/6N
abnormal cytokine level J:251372
abnormal lung thrombosis J:251372
abnormal spleen morphology J:251372
decreased single-positive T cell number J:251372
enlarged spleen J:251372
increased circulating interleukin-10 level J:251372
increased circulating interleukin-13 level J:251372
increased circulating tumor necrosis factor level J:251372
increased IgM level J:251372
increased myeloid cell number J:251372
lung inflammation J:251372
pleural effusion J:251372
normal renal/urinary system phenotype J:251372
respiratory distress J:251372
skin lesions J:251372
spontaneous skin ulceration J:251372
\Sting1em1Jmin/\Sting1em1Jmin
involves: C57BL/6N
prenatal lethality, complete penetrance J:251372
\Sting1em1Osb/\Sting1em1Osb
involves: C57BL/6NJcl * DBA/2NJcl
reproductive system phenotype J:348425
\Sting1gt/\Sting1gt
C57BL/6-Sting1gt
abnormal dendritic cell physiology J:201167
abnormal humoral immune response J:201167
abnormal immune cell physiology J:201167
abnormal macrophage physiology J:201167
abnormal plasmacytoid dendritic cell physiology J:201167
abnormal response to infection J:168746
decreased circulating interferon-alpha level J:201167
decreased circulating interferon-beta level J:168746, J:201167
increased susceptibility to Herpesvirales infection J:201167
increased susceptibility to Herpesvirales infection induced morbidity/mortality J:201167
\Sting1gt/\Sting1gt
C57BL/6J-Sting1gt/J
abnormal interferon-beta secretion J:354143
abnormal level of surface class I molecules J:363611
abnormal MHC II cell surface expression on macrophages J:363611
abnormal response to infection J:354143
increased susceptibility to Retroviridae infection J:354143
\Sting1gt/\Sting1gt
involves: C57BL/6
decreased enterocyte apoptosis J:269933
normal hematopoietic system phenotype J:265023
normal immune system phenotype J:265023
increased susceptibility to Retroviridae infection J:265023
\Sting1tm1.1(KOMP)Mbp/\Sting1tm1.1(KOMP)Mbp
C57BL/6NCrl-Sting1tm1.1(KOMP)Mbp/MbpMmucd
female infertility J:211773
\Sting1tm1Camb/\Sting1tm1Camb
involves: C57BL/6N
decreased circulating interferon-beta level J:179270
decreased circulating interleukin-6 level J:179270
normal immune system phenotype J:179270
\Sting1tm1Gnb/\Sting1tm1Gnb
involves: 129P2/OlaHsd
abnormal response to infection J:168746
\Sting1tm1Gnb/\Sting1tm1Gnb
involves: 129P2/OlaHsd * C57BL/6
abnormal innate immunity J:141011
abnormal susceptibility to Herpesvirales infection J:141011
increased susceptibility to Riboviria infection J:141011

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory