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Smg1 Gene Detail
Summary
  • Symbol
    Smg1
  • Name
    SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
  • Synonyms
    2610207I05Rik, 5430435M13Rik, C130002K18Rik, mKIAA0421
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919742
    NCBI Gene: 233789
  • Gene Overview
    MyGene.info: SMG1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:118131308-118243657 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 63.44 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    449 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919742
protein coding gene Chr7:118131308-118243670 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032896
protein coding gene Chr7:121942542-122069310 (-)
A/J MGP_AJ_G0032879
protein coding gene Chr7:118866019-118978320 (-)
AKR/J MGP_AKRJ_G0032811
protein coding gene Chr7:121879943-122014404 (-)
BALB/cJ MGP_BALBcJ_G0032884
protein coding gene Chr7:118589341-118708470 (-)
C3H/HeJ MGP_C3HHeJ_G0032594
protein coding gene Chr7:121800650-121920000 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033390
protein coding gene Chr7:126810189-126940631 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030362
protein coding gene Chr7:120332901-120439996 (-)
CAST/EiJ MGP_CASTEiJ_G0031922
protein coding gene Chr7:113538303-113655438 (-)
CBA/J MGP_CBAJ_G0032567
protein coding gene Chr7:131034751-131182929 (-)
DBA/2J MGP_DBA2J_G0032719
protein coding gene Chr7:116904832-117024086 (-)
FVB/NJ MGP_FVBNJ_G0032672
protein coding gene Chr7:116747552-116863489 (-)
LP/J MGP_LPJ_G0032813
protein coding gene Chr7:123425451-123547170 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032704
protein coding gene Chr7:132569020-132701210 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033410
protein coding gene Chr7:120878126-121002055 (-)
PWK/PhJ MGP_PWKPhJ_G0031630
protein coding gene Chr7:109793749-109916048 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031477
protein coding gene Chr7:107626737-107748015 (-)
WSB/EiJ MGP_WSBEiJ_G0032035
protein coding gene Chr7:121770912-121895327 (-)



Homology
more
  • Human Ortholog
    SMG1, SMG1, nonsense mediated mRNA decay associated PI3K related kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SMG1, SMG1, nonsense mediated mRNA decay associated PI3K related kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    61E3.4, ATX, LIP
  • Links
    NCBI Gene ID: 23049
    neXtProt AC: NX_Q96Q15
    UniProt: Q96Q15

  • Chr Location
    16p12.3; chr16:18804853-18926417 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 56697
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SMG1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit early embryonic lethality. Mice heteroygous for a gene trap allele exhibit abnormal tooth development, chronic inflammation, increased body weight, increased incidence of tumor formation and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 233789 NCBI Gene Model | MGI Sequence Detail 112350 C57BL/6J ±  kb
transcript NM_001031814 RefSeq | MGI Sequence Detail 15553 Not Specified  
polypeptide Q8BKX6 UniProt | EBI | MGI Sequence Detail 3658 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 183
    cDNA 183

    Microarray probesets 5
Other
Accession IDs
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MGI:1918594, MGI:2444194
References
more
  • Summaries
    All 43
    Gene Ontology 5
    Phenotypes 15
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:261316 Perez-Garcia V, et al., Placentation defects are highly prevalent in embryonic lethal mouse mutants. Nature. 2018 Mar 22;555(7697):463-468

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory