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Lrpprc
Gene Detail
Symbol

Name
ID
Lrpprc
leucine-rich PPR-motif containing
MGI:1919666
Synonyms
3110001K13Rik, Lrp130
Feature Type
protein coding gene
Genetic Map
Chromosome 17
55.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:84705247-84790789 bp, - strand
From VEGA annotation of GRCm38

  85543 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32695  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LRPPRC
Gene Tree: Lrpprc

Human
homologs
LRPPRC, leucine-rich pentatricopeptide repeat containing
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10128
neXtProt AC: NX_P42704

Human Synonyms: CLONE-23970, GP130, LRP130, LSFC

Human Chr (Location): 2p21; chr2:43886224-43996005 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LRPPRC

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(10) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele exhibit embryonic lethality during organogenesis associated with growth retardation. Mice homozygous for a knock-out allele exhibit embryonic lethality between somite formation and embryo turning.
 
Interactions
Lrpprc interacts with 74 markers (Mir20a, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process mRNA transport, negative regulation of mitochondrial RNA catabolic process, ...
Component condensed nuclear chromosome, cytoplasm, ...
Function beta-tubulin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (14)    Tissues (14)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 12
RT-PCR 2
cDNA source data(135)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lrpprc ; ZFIN lrpprc    NEW 
Molecular
reagents
All nucleic(136) cDNA(135) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000030887 (Evidence)
Ensembl Gene Model ENSMUSG00000024120 (Evidence)
Entrez Gene 72416 (Evidence)
UniGene 217027
DFCI TC1580134, TC1598436, TC1610640
DoTS DT.87045043, DT.97336873, DT.110566378, DT.533439, DT.101391440, DT.101151208
NIA Mouse Gene Index U038114
Consensus CDS Project CCDS29003.2
International Mouse Phenotyping Consortium Status Lrpprc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030887 VEGA Gene Model | MGI Sequence Detail 85543 C57BL/6J ±  kb
transcript OTTMUST00000076447 VEGA | MGI Sequence Detail 4393 Not Applicable 
polypeptide OTTMUSP00000040245 VEGA | MGI Sequence Detail 1392 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(448 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002885 Pentatricopeptide repeat
Protein Ontology PR:000009930 leucine-rich PPR motif-containing protein, mitochondrial
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:209159 Mourier A, et al., Loss of LRPPRC causes ATP synthase deficiency. Hum Mol Genet. 2014 May 15;23(10):2580-92
All references(38)
Other
accession IDs
MGI:2145077

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory