Lrpprc
Gene Detail

Symbol Name ID

Lrpprc leucine-rich PPR-motif containing MGI:1919666

Synonyms

3110001K13Rik, Lrp130

Feature Type

protein coding gene

Genetic Map

Chromosome 17

55.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr17:84705247-84790789 bp, - strand From VEGA annotation of GRCm38   85543 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32695  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lrpprc

Human homologs

Human Homolog		LRPPRC, leucine-rich pentatricopeptide repeat containing
NCBI Gene ID		10128
neXtProt AC		NX_P42704
Human Synonyms		CLONE-23970, GP130, LRP130, LSFC
Human Chr (Location)		2p21; chr2:44113363-44223144 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LRPPRC

Alleles and phenotypes

All alleles(13) : Targeted(3) Gene trapped(10)
 

Mice homozygous for a gene trap allele exhibit embryonic lethality during organogenesis associated with growth retardation. Mice homozygous for a knock-out allele exhibit embryonic lethality between somite formation and embryo turning.

 

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	mRNA transport, negative regulation of mitochondrial RNA catabolic process, ...
Component	condensed nuclear chromosome, cytoplasm, ...
Function	beta-tubulin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (14)    Tissues (13)   
Theiler Stages: 10, 18, 21, 23, 25, 28

Assay Type	Results
Northern blot	12
RT-PCR	2

cDNA source data(135)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(136) cDNA(135) Primer pair(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000030887 (Evidence)
Ensembl Gene Model	ENSMUSG00000024120 (Evidence)
Entrez Gene	72416 (Evidence)
UniGene	217027
DFCI	TC1580134, TC1598436, TC1610640
DoTS	DT.101151208, DT.101391440, DT.110566378, DT.533439, DT.87045043, DT.97336873
NIA Mouse Gene Index	U038114
Consensus CDS Project	CCDS29003.2
International Mouse Knockout Project Status	Lrpprc

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030887	VEGA Gene Model | MGI Sequence Detail	85543	C57BL/6J
transcript	OTTMUST00000076447	VEGA | MGI Sequence Detail	4393	Not Applicable
polypeptide	OTTMUSP00000040245	VEGA | MGI Sequence Detail	1392	Not Applicable

All sequences(46) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(235 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002885	Pentatricopeptide repeat
InterPro	IPR011990	Tetratricopeptide-like helical
Protein Ontology	PR:000009930	leucine-rich PPR motif-containing protein, mitochondrial

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:187800 Ruzzenente B, et al., LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs. EMBO J. 2012 Jan 18;31(2):443-56
All references(39)

Other accession IDs

MGI:2145077