About   Help   FAQ
Pinx1
Gene Detail
Symbol

Name
ID
Pinx1
PIN2/TERF1 interacting, telomerase inhibitor 1
MGI:1919650
Synonyms
2210403I16Rik, 2610028A01Rik, LPTS
Feature Type
protein coding gene
Genetic Map
Chromosome 14
33.34 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:63860312-63919859 bp, + strand
From NCBI annotation of GRCm38

  59548 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134540  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Pinx1

Human
homologs
Human Homolog PINX1, PIN2/TERF1 interacting, telomerase inhibitor 1
NCBI Gene ID 54984
neXtProt AC  NX_Q96BK5
Human Synonyms  LPTL, LPTS
Human Chr (Location)  8p23; chr8:10764961-10839899 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit decreased embryonic size, pallor, anemia, and die during organogenesis. Mice heterozygous for a knock-out allele exhibit increased tumor incidence associated with chromosomal instability and elongated telomeres.
 
Phenotype Images(12)
Interactions
Pinx1 interacts with 45 markers (Mir134, Mir138-2, Mir147, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process mitotic metaphase plate congression, telomere maintenance via telomerase
Component chromosome, chromosome, centromeric region, ...
Function nucleic acid binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (22)    Tissues (22)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 20
RT-PCR 2
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000021958 (Evidence)
Entrez Gene72400 (Evidence)
DFCITC1583300, TC1625941, TC1658425
DoTSDT.101228689, DT.101376961, DT.97363630
NIA Mouse Gene IndexU015756
Consensus CDS ProjectCCDS27205.1
International Mouse Knockout Project StatusPinx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 72400 NCBI Gene Model | MGI Sequence Detail 59548 C57BL/6J ±  kb
transcript NM_028228 RefSeq | MGI Sequence Detail 1351 C57BL/6 
polypeptide Q9CZX5 UniProt | EBI | MGI Sequence Detail 332 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(9) UniProt(1)
Polymorphisms
SNPs within 2kb(246 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000467 G-patch domain
Protein Ontology PR:000012738 pin2-interacting protein X1
Graphical View of Protein Domain Structure
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)
Other
accession IDs
MGI:1914881, MGI:2145748

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory