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Pinx1 Gene Detail
Summary
  • Symbol
    Pinx1
  • Name
    PIN2/TERF1 interacting, telomerase inhibitor 1
  • Synonyms
    2210403I16Rik, 2610028A01Rik, LPTS
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919650
    NCBI Gene: 72400
  • Gene Overview
    MyGene.info: PINX1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:63860364-63919859 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      59496 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 33.34 cM, cytoband C3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PINX1, PIN2 (TERF1) interacting telomerase inhibitor 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    PINX1, PIN2 (TERF1) interacting telomerase inhibitor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Gno1, LPTL, LPTS, Pxr1
  • Links
    NCBI Gene ID: 54984
    neXtProt AC: NX_Q96BK5
    UniProt: Q96BK5

  • Chr Location
    8p23.1; chr8:10764961-10839899 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 1 allele in 1 genetic background
    12 phenotypes from multigenic genotypes
    12 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased embryonic size, pallor, anemia, and die during organogenesis. Mice heterozygous for a knock-out allele exhibit increased tumor incidence associated with chromosomal instability and elongated telomeres.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021958 Ensembl Gene Model | MGI Sequence Detail 59496 C57BL/6J ±  kb
    transcript ENSMUST00000022528 Ensembl | MGI Sequence Detail 1295 Not Applicable  
    polypeptide ENSMUSP00000022528 Ensembl | MGI Sequence Detail 332 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      245 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 7
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1914881, MGI:2145748
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 8
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory