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Brf1 Gene Detail
Summary
  • Symbol
    Brf1
  • Name
    BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
  • Synonyms
    2510002F24Rik, GTF3B, TAF3C, TAFIII90, TFIIIB90
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919558
    NCBI Gene: 72308
  • Gene Overview
    MyGene.info: BRF1
Location & Maps
more
  • Sequence Map
    Chr12:112959862-113000621 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40760 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 61.47 cM, cytoband F2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    BRF1, BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BRF1, BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BRF, BRF-1, CFDS, GTF3B, hBRF, HEL-S-76p, TAF3B2, TAF3C, TAFIII90, TF3B90, TFIIIB90
  • Links
    NCBI Gene ID: 2972
    neXtProt AC: NX_Q92994

  • Chr Location
    14q; chr14:105209286-105315577 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1161
    1 human;1 mouse;1 rat;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: BRF1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human BRF1 associations

Human Disease Mouse Models
       Cerebellofaciodental Syndrome; CFDS   OMIM: 616202
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    5
  • Gene trapped
    3
  • Targeted
    2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000011158 Ensembl Gene Model | MGI Sequence Detail 40760 C57BL/6J ±  kb
transcript ENSMUST00000011302 Ensembl | MGI Sequence Detail 2755 Not Applicable  
polypeptide ENSMUSP00000011302 Ensembl | MGI Sequence Detail 676 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    371 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000004812 transcription factor IIIB 90 kDa subunit
  • InterPro Domains
    IPR011665 Brf1, TBP-binding domain
    IPR013763 Cyclin-like
    IPR029529 Transcription factor IIIB subunit Brf1
    IPR000812 Transcription factor TFIIB
    IPR013150 Transcription factor TFIIB, cyclin-like domain
    IPR013137 Zinc finger, TFIIB-type
Molecular
Reagents
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  • All nucleic 7
    cDNA 7

    Microarray probesets 2
References
more
  • Summaries
    All 27
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory