Brf1 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Brf1
BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
MGI:1919558

14 phenotypes from 2 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Brf1^tm1.1Arte/Brf1⁺ involves: BALB/cJ	delayed blastocyst hatching from the zona pellucida	J:285667
Brf1^tm1.1Arte/Brf1⁺ involves: BALB/cJ	preweaning lethality, incomplete penetrance	J:285667
Brf1^tm1.1Arte/Brf1^tm1.1Arte involves: BALB/cJ	embryonic lethality, complete penetrance	J:285667
Brf1^tm1.1Arte/Brf1^tm1.1Arte involves: BALB/cJ	failure of blastocyst formation	J:285667
Brf1^tm1Arte/Brf1^tm1Arte Not Specified	decreased body weight	J:285667
	increased circulating alanine transaminase level	J:285667
	increased circulating alkaline phosphatase level	J:285667
	increased circulating bilirubin level	J:285667
Brf1^tm1Arte/Brf1^tm1Arte Tg(Cyp1a1-cre)1Dwi/0 involves: C57BL/6 * CBA	abnormal translation	J:285667
	hepatic necrosis	J:285667
	increased hepatocyte apoptosis	J:285667
	liver inflammation	J:285667
	small liver	J:285667
Brf1^tm1Arte/Brf1^tm1Arte Tg(Pdx1-cre)6Tuv/0 involves: FVB/N	normal endocrine/exocrine gland phenotype	J:285667

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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