Cyp2c65 MGI Mouse Gene Detail - MGI:1919553 - cytochrome P450, family 2, subfamily c, polypeptide 65

Symbol

Cyp2c65
Name

cytochrome P450, family 2, subfamily c, polypeptide 65
Synonyms

2210009K14Rik

Feature Type

protein coding gene
IDs

MGI:1919553
NCBI Gene: 72303
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr19:39049459-39082388 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 33.70 cM, cytoband D1
Mapping Data

2 experiments

SNPs within 2kb

144 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919553	protein coding gene	Chr19:39049450-39082392 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025098	protein coding gene	Chr19:38188056-38218555 (+)
A/J	MGP_AJ_G0025074	protein coding gene	Chr19:36328733-36360201 (+)
AKR/J	MGP_AKRJ_G0025042	protein coding gene	Chr19:37536541-37570516 (+)
BALB/cJ	MGP_BALBcJ_G0025072	protein coding gene	Chr19:36417408-36453209 (+)
C3H/HeJ	MGP_C3HHeJ_G0024831	protein coding gene	Chr19:37633843-37670586 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025513	protein coding gene	Chr19:39235768-39271708 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022932	protein coding gene	Chr19:35627639-35658527 (+)
CAST/EiJ	MGP_CASTEiJ_G0024298	protein coding gene	Chr19:37493372-37562174 (+)
CBA/J	MGP_CBAJ_G0024808	protein coding gene	Chr19:41150404-41179462 (+)
DBA/2J	MGP_DBA2J_G0024940	protein coding gene	Chr19:36154191-36186422 (+)
FVB/NJ	MGP_FVBNJ_G0024901	protein coding gene	Chr19:35978704-36009841 (+)
LP/J	MGP_LPJ_G0025026	protein coding gene	Chr19:38258242-38305317 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024932	protein coding gene	Chr19:40821552-40852503 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025571	protein coding gene	Chr19:37652703-37685619 (+)
PWK/PhJ	MGP_PWKPhJ_G0024050	protein coding gene	Chr19:36023929-36063130 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023850	protein coding gene	Chr19:36469912-36731419 (+)
WSB/EiJ	MGP_WSBEiJ_G0024366	protein coding gene	Chr19:37746250-37781008 (+)

Human Ortholog

CYP2C8, cytochrome P450 family 2 subfamily C member 8

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CYP2C8, cytochrome P450 family 2 subfamily C member 8
Synonyms

CPC8, CYP2C8DM, CYPIIC8, MP-12/MP-20
Links

HGNC:2622

NCBI Gene ID: 1558

neXtProt AC: NX_P10632

UniProt: P10632
Chr Location

10q23.33; chr10:95036772-95069497 (-) GRCh38

Human Ortholog

CYP2C9, cytochrome P450 family 2 subfamily C member 9
Synonyms

CPC9, CYP2C, CYP2C10, CYPIIC9, P450-2C9, P450IIC9
Links

HGNC:2623

NCBI Gene ID: 1559

neXtProt AC: NX_P11712

UniProt: P11712
Chr Location

10q23.33; chr10:94938658-94990091 (+) GRCh38

MGI Vertebrate Homology

Cyp2c65 stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CYP2C8, CYP2C9
Gene Tree

Cyp2c65

Diseases

20 with human CYP2C19,CYP2C8,CYP2C9 associations

				Human Disease	Mouse Models
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142
				diabetes mellitus IDs diabetes mellitus DOID:9351 ICD10CM:E08-E13 ICD9CM:250 MESH:D003920 NCI:C2985 UMLS_CUI:C0011849
				end stage renal disease IDs end stage renal disease DOID:783
				eosinophilic esophagitis IDs eosinophilic esophagitis DOID:13922 EFO:0004232 ICD10CM:K20.0 ICD9CM:530.13 MESH:D057765 NCI:C27105 OMIM:610247 OMIM:613412 ORDO:73247 UMLS_CUI:C0341106
				head and neck squamous cell carcinoma IDs head and neck squamous cell carcinoma DOID:5520 MESH:D000077195 NCI:C34447 OMIM:275355 UMLS_CUI:C1168401
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176
				hyperglycemia IDs hyperglycemia DOID:4195 ICD10CM:R73.9 MESH:D006943 NCI:C26797 UMLS_CUI:C0020456
				hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538
				hypoglycemia IDs hypoglycemia DOID:9993 ICD10CM:E16.2 ICD9CM:251.2 MESH:D007003 NCI:C3126 UMLS_CUI:C0020615
				invasive aspergillosis IDs invasive aspergillosis DOID:0050073
				multiple chemical sensitivity IDs multiple chemical sensitivity DOID:4661 MESH:D018777 UMLS_CUI:C0242992
				multiple myeloma IDs multiple myeloma DOID:9538 EFO:0001378 ICD10CM:C90.0 ICD9CM:203.0 MESH:D009101 NCI:C3242 OMIM:254500 ORDO:29073 UMLS_CUI:C0026764
				peptic ulcer disease IDs peptic ulcer disease DOID:750 DOID:11466 DOID:12635 DOID:13115 ICD10CM:K27 ICD9CM:533 MESH:D010437 NCI:C3318 UMLS_CUI:C0030920
				Plasmodium falciparum malaria IDs Plasmodium falciparum malaria DOID:14067 ICD10CM:B50 ICD9CM:084.0 ICD9CM_2006:084.0 MESH:D016778 NCI:C34798 UMLS_CUI:C0024535
				renal hypertension IDs renal hypertension DOID:1073 MESH:D006977 NCI:C3121 UMLS_CUI:C0020544
				sickle cell anemia IDs sickle cell anemia DOID:10923 DOID:12924 DOID:13024 ICD10CM:D57.1 ICD10CM:D57.2 ICD9CM_2006:282.63 ICD9CM:282.6 ICD9CM:282.60 ICD9CM:282.63 MESH:D000755 MESH:D006450 NCI:C34383 NCI:C34676 OMIM:603903 ORDO:232 UMLS_CUI:C0002895 UMLS_CUI:C0019034
				tuberculosis IDs tuberculosis DOID:399 DOID:10096 DOID:12688 DOID:12691 DOID:415 DOID:9901 DOID:9902 MESH:D014375 UMLS_CUI:C0041295
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860
				urinary bladder cancer IDs urinary bladder cancer DOID:11054 DOID:5428 ICD10CM:C67 ICD9CM:188 ICD9CM:188.9 KEGG:05219 MESH:D001749 NCI:C2901 NCI:C9334 OMIM:109800 UMLS_CUI:C0005684 UMLS_CUI:C0005695
				warfarin resistance IDs warfarin resistance DOID:0080665 OMIM:122700

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotype references

All Mutations and Alleles

4
Targeted

4
Genomic Mutations

2 involving Cyp2c65
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

30 strains or lines available

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All GO Annotations

21
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

8
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

34
RefSeq

2
UniProt

4
CCDS

CCDS29791.1

Ensembl

ENSMUSG00000067231 (Evidence)
NCBI Gene

72303

			Length	Strain/Species	Flank
genomic	ENSMUSG00000067231	Ensembl Gene Model \| MGI Sequence Detail	32930	C57BL/6J	± kb
transcript	ENSMUST00000087236	Ensembl \| MGI Sequence Detail	1928	Not Applicable
polypeptide	ENSMUSP00000084489	Ensembl \| MGI Sequence Detail	490	Not Applicable

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UniProt

4 Sequences
InterPro Domains

IPR001128 Cytochrome P450

IPR017972 Cytochrome P450, conserved site

IPR002401 Cytochrome P450, E-class, group I

IPR036396 Cytochrome P450 superfamily

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All nucleic 9

cDNA 8

Primer pair 1

Microarray probesets 2

Summaries

All 25

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:341617 Zhang J, et al., CYP eicosanoid pathway mediates colon cancer-promoting effects of dietary linoleic acid. FASEB J. 2023 Jul;37(7):e23009

TSS for Cyp2c65:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156319	Chr19:39049442-39049459 (+)	-8 bp
Tssr156320	Chr19:39049496-39049527 (+)	53 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23