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Bag6
Gene Detail
Symbol

Name
ID
Bag6
BCL2-associated athanogene 6
MGI:1919439
Synonyms
2410045D21Rik, Bat3, D17H6S52E, G3, Scythe
Feature Type
protein coding gene
Genetic Map
Chromosome 17
18.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr17:35135178-35147320 bp, + strand
From VEGA annotation of GRCm38

  12143 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3409  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Bag6

Human
homologs
Human Homolog BAG6, BCL2-associated athanogene 6
NCBI Gene ID 7917
neXtProt AC  NX_P46379
Human Synonyms  BAG-6, BAT3, D6S52E, G3
Human Chr (Location)  6p21.3; chr6:31639028-31660767 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(10) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted disruption of this gene results in either embryonic lethality following abnormal brain development or neonatal death associated with severe developmental defects in the lung and kidney. These developmental defects are associated with widespread aberrant apoptosis and proliferation.
 
Interactions
Bag6 interacts with 68 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process antigen processing and presentation of peptide antigen via MHC class I, apoptotic process, ...
Component BAT3 complex, cytoplasm, ...
Function Hsp70 protein binding, polyubiquitin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(261)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(280) Genomic(17) cDNA(262) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037183 (Evidence)
Ensembl Gene ModelENSMUSG00000024392 (Evidence)
Entrez Gene224727 (Evidence)
UniGene203962
DFCITC1622374, TC1623979, TC1656290, TC1669507, TC1690454
DoTSDT.101398355, DT.101398360, DT.494624, DT.94369819, DT.94369880, DT.99871624
NIA Mouse Gene IndexU017892
Consensus CDS ProjectCCDS28688.1, CCDS57072.1, CCDS57073.1
International Mouse Knockout Project StatusBag6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037183 VEGA Gene Model | MGI Sequence Detail 12143 C57BL/6J ±  kb
transcript OTTMUST00000095814 VEGA | MGI Sequence Detail 3787 Not Applicable 
polypeptide OTTMUSP00000053489 VEGA | MGI Sequence Detail 1136 Not Applicable 

For the selected sequences
All sequences(218) RefSeq(94) UniProt(14)
Polymorphisms
SNPs within 2kb(50 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021925 Protein of unknown function DUF3538
InterPro IPR000626 Ubiquitin
InterPro IPR019954 Ubiquitin conserved site
Protein Ontology PR:000004651 large proline-rich protein BAT3
References
(Earliest) J:1314 Lafuse WP, et al., PFGE mapping and RFLP analysis of the S/D region of the mouse H-2 complex. Immunogenetics. 1992;36(2):110-6
(Latest) J:207394 Sebti S, et al., BAT3 modulates p300-dependent acetylation of p53 and autophagy-related protein 7 (ATG7) during autophagy. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4115-20
All references(54)
Other
accession IDs
MGD-MRK-1508, MGD-MRK-16249, MGI:2146754, MGI:99475

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory