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Chst14 Gene Detail
Summary
  • Symbol
    Chst14
  • Name
    carbohydrate sulfotransferase 14
  • Synonyms
    2600016L03Rik, D4st1, D4ST-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919386
    NCBI Gene: 72136
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:118756978-118759066 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 59.73 cM, cytoband E5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    88 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919386
 protein coding gene Chr2:118756977-118759066 (+)
129S1/SvImJ ENSMUSG00200044386
 protein coding gene Chr2:115697012-115699101 (+)
A/J ENSMUSG00195021357
 protein coding gene Chr2:115745285-115747374 (+)
AKR/J ENSMUSG00220034060
 protein coding gene Chr2:115623510-115625599 (+)
BALB/cJ ENSMUSG00180040008
 protein coding gene Chr2:115550412-115552501 (+)
C3H/HeJ ENSMUSG00175024982
 protein coding gene Chr2:116010602-116012691 (+)
C57BL/6NJ ENSMUSG00215027788
 protein coding gene Chr2:115673720-115675809 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024128
 protein coding gene Chr2:111746584-111748686 (+)
CAST/EiJ ENSTCUG00005015412
 protein coding gene Chr2:114949225-114951314 (+)
CBA/J ENSMUSG00210006668
 protein coding gene Chr2:115851563-115853652 (+)
DBA/2J ENSMUSG00185047653
 protein coding gene Chr2:115547101-115549190 (+)
FVB/NJ ENSMUSG00205026557
 protein coding gene Chr2:114761846-114763935 (+)
JF1/MsJ ENSUMUG00000016183
 protein coding gene Chr2:115412329-115414418 (+)
LP/J ENSMUSG00230019298
 protein coding gene Chr2:117356681-117358770 (+)
NOD/ShiLtJ ENSMUSG00190034521
 protein coding gene Chr2:115779911-115782000 (+)
NZO/HlLtJ ENSMUSG00225002762
 protein coding gene Chr2:125258233-125260322 (+)
PWK/PhJ ENSLUMG00010046071
 protein coding gene Chr2:115321220-115323309 (+)
SPRET/EiJ ENSMSPG00010037707
 protein coding gene Chr2:117728284-117730377 (+)
WSB/EiJ ENSIUOG00005021727
 protein coding gene Chr2:115511260-115513349 (+)



Homology
more
  • Human Ortholog
    CHST14, carbohydrate sulfotransferase 14
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHST14, carbohydrate sulfotransferase 14
  • Synonyms
    ATCS, D4ST1, EDSMC1, HNK1ST
  • Links
    NCBI Gene ID: 113189
    UniProt: Q8NCH0

  • Chr Location
    15q15.1; chr15:40470984-40473158 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Chst14 mouse models; 1 with human CHST14 associations

Human Disease Mouse Models
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 5 alleles in 6 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit accelerated peripheral nerve regeneration, decreased body weight, premature death, fragile skin and background sensitive abnormal fertility, kinked tail and tooth growth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    614
  • Tissues
    13
  • cDNA Data
    15
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72136 NCBI Gene Model | MGI Sequence Detail 2089 C57BL/6J ±  kb
    transcript NM_028117 RefSeq | MGI Sequence Detail 2089 C57BL/6  
    polypeptide Q80V53 UniProt | EBI | MGI Sequence Detail 376 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 11
      Phenotypes 24
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:387338 Takahashi Y, et al., Comprehensive analysis of the skeletal phenotype in Chst14-/- mice: implications for dermatan sulfate in bone structure and strength. Glycobiology. 2026 May 22;36(7)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory