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Tpx2 Gene Detail
Summary
  • Symbol
    Tpx2
  • Name
    TPX2, microtubule-associated
  • Synonyms
    2610005B21Rik, DIL2, p100, REPP86
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919369
    NCBI Gene: 72119
  • Gene Overview
    MyGene.info: TPX2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:152847964-152895321 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 75.41 cM, cytoband H2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    337 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919369
protein coding gene Chr2:152847964-152895321 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026679
protein coding gene Chr2:157435417-157493828 (+)
A/J MGP_AJ_G0026645
protein coding gene Chr2:151146869-151194434 (+)
AKR/J MGP_AKRJ_G0026615
protein coding gene Chr2:155564008-155614704 (+)
BALB/cJ MGP_BALBcJ_G0026654
protein coding gene Chr2:151456668-151504166 (+)
C3H/HeJ MGP_C3HHeJ_G0026397
protein coding gene Chr2:155935983-155985681 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027103
protein coding gene Chr2:161997861-162054872 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024474
protein coding gene Chr2:144736995-144786210 (+)
CAST/EiJ MGP_CASTEiJ_G0025858
protein coding gene Chr2:156190755-156241435 (+)
CBA/J MGP_CBAJ_G0026375
protein coding gene Chr2:167962511-168024156 (+)
DBA/2J MGP_DBA2J_G0026511
protein coding gene Chr2:150356803-150404783 (+)
FVB/NJ MGP_FVBNJ_G0026477
protein coding gene Chr2:148816568-148868403 (+)
LP/J MGP_LPJ_G0026615
protein coding gene Chr2:157586338-157642419 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026498
protein coding gene Chr2:172040627-172091067 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027159
protein coding gene Chr2:155453621-155506064 (+)
PWK/PhJ MGP_PWKPhJ_G0025592
protein coding gene Chr2:149880517-149928734 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025395
protein coding gene Chr2:154294833-154340941 (+)
WSB/EiJ MGP_WSBEiJ_G0025928
protein coding gene Chr2:156361255-156412429 (+)



Homology
more
  • Human Ortholog
    TPX2, TPX2 microtubule nucleation factor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TPX2, TPX2 microtubule nucleation factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C20orf1, C20orf2, DIL2, DIL-2, FLS353, GD:C20orf1, HCA519, HCTP4, p100, REPP86
  • Links
    NCBI Gene ID: 22974
    neXtProt AC: NX_Q9ULW0
    UniProt: Q9ULW0

  • Chr Location
    20q11.21; chr20:31739101-31801802 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8107
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TPX2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 3 alleles in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit embryonic arrest at the morula stage, embryonic lethality and tetraploidy of cultured E1.5 embryos. Mice heterozygous for the gene trap allele exhibit aneuploidy and increased tumor incidence.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72119 NCBI Gene Model | MGI Sequence Detail 47358 C57BL/6J ±  kb
    transcript NM_001141977 RefSeq | MGI Sequence Detail 4365 C57BL/6  
    polypeptide A2APB8 UniProt | EBI | MGI Sequence Detail 745 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 5
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:282460 Rong Y, et al., ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation. Nucleic Acids Res. 2019 Dec 2;47(21):11387-11402

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    05/26/2020
    MGI 6.15
    The Jackson Laboratory