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Tpx2
Gene Detail
 Symbol
Name
ID
Tpx2
TPX2, microtubule-associated protein homolog (Xenopus laevis)
MGI:1919369
Synonyms 2610005B21Rik, DIL2, p100, REPP86
Feature Type protein coding gene
Genetic Map
Chromosome 2
75.41 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:152847978-152894654 bp, + strand
From VEGA annotation of GRCm38

  46677 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8107  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Tpx2

Human
homologs
Human Homolog TPX2, TPX2, microtubule-associated
NCBI Gene ID 22974
neXtProt AC  NX_Q9ULW0
Human Synonyms  C20orf1, C20orf2, DIL2, DIL-2, FLS353, GD:C20orf1, HCA519, HCTP4, p100, REPP86
Human Chr (Location)  20q11.2; chr20:31739101-31801802 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(120) : Gene trapped(118) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele exhibit embryonic arrest at the morula stage, embryonic lethality and tetraploidy of cultured E1.5 embryos. Mice heterozygous for the gene trap allele exhibit aneuploidy and increased tumor incidence.
 
Interactions
Tpx2 interacts with 251 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process activation of protein kinase activity, apoptotic process, ...
Component aster, axon hillock, ...
Function protein binding, protein kinase binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000015861 (Evidence)
Ensembl Gene ModelENSMUSG00000027469 (Evidence)
Entrez Gene72119 (Evidence)
DFCITC1572503, TC1601413, TC1627761, TC1683414, TC1683903, TC1688197
DoTSDT.101395172, DT.101395175, DT.101737513, DT.102542941, DT.110672213, DT.110721938
NIA Mouse Gene IndexU002656
Consensus CDS ProjectCCDS16900.1
International Mouse Knockout Project StatusTpx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015861 VEGA Gene Model | MGI Sequence Detail 46677 C57BL/6J ±  kb
transcript OTTMUST00000037690 VEGA | MGI Sequence Detail 3483 Not Applicable 
polypeptide OTTMUSP00000016904 VEGA | MGI Sequence Detail 745 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(16) UniProt(3)
Polymorphisms SNPs within 2kb(335 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015128 Aurora-A binding
InterPro IPR009675 TPX2
InterPro IPR027330 TPX2, central domain
InterPro IPR027329 TPX2, C-terminal domain
Protein Ontology PR:000016598 targeting protein for Xklp2
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:206141 Eguren M, et al., The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors. Nat Commun. 2013;4:2880
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory