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Tpx2 Gene Detail
Summary
  • Symbol
    Tpx2
  • Name
    TPX2, microtubule-associated
  • Synonyms
    2610005B21Rik, DIL2, p100, REPP86
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919369
    NCBI Gene: 72119
  • Gene Overview
    MyGene.info: TPX2
Location & Maps
more
  • Sequence Map
    Chr2:152847978-152894654 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      46677 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 75.41 cM, cytoband H2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TPX2, TPX2, microtubule nucleation factor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TPX2, TPX2, microtubule nucleation factor
    Orthology source: HomoloGene
  • Synonyms
    C20orf1, C20orf2, DIL2, DIL-2, FLS353, GD:C20orf1, HCA519, HCTP4, p100, REPP86
  • Links
    NCBI Gene ID: 22974
    neXtProt AC: NX_Q9ULW0

  • Chr Location
    20q11.2; chr20:31733819-31801802 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8107
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog
  • HCOP
    human homology predictions: TPX2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 3 alleles in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    122
  • Chemically induced (other)
    1
  • Gene trapped
    118
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Tpx2
  • Incidental Mutations
Mice homozygous for a gene trap allele exhibit embryonic arrest at the morula stage, embryonic lethality and tetraploidy of cultured E1.5 embryos. Mice heterozygous for the gene trap allele exhibit aneuploidy and increased tumor incidence.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015861 VEGA Gene Model | MGI Sequence Detail 46677 C57BL/6J ±  kb
transcript OTTMUST00000037690 VEGA | MGI Sequence Detail 3483 Not Applicable  
polypeptide OTTMUSP00000016904 VEGA | MGI Sequence Detail 745 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    332 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 5
References
more
  • Summaries
    All 39
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:224841 Wei JH, et al., GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2 and Capturing Microtubules. Cell. 2015 Jul 16;162(2):287-99

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory