Tpx2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tpx2
TPX2, microtubule-associated
MGI:1919369

22 phenotypes from 4 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tpx2^em1(IMPC)J/Tpx2^em1(IMPC)J C57BL/6NJ-Tpx2^em1(IMPC)J/Mmjax	embryonic lethality prior to organogenesis	J:211773
	preweaning lethality, complete penetrance	J:211773
Tpx2^{Gt(D028B03)1.1Wrst}/Tpx2^{Gt(D028B03)1.1Wrst} involves: 129S2/SvPas * C57BL/6J	abnormal cell nucleus morphology	J:184948
	abnormal mitosis	J:184948
	abnormal mitotic spindle assembly checkpoint	J:184948
	decreased cell proliferation	J:184948
	polyploidy	J:184948
Tpx2^{Gt(D028B03)1.2Wrst}/Tpx2^{Gt(D028B03)1.2Wrst} involves: 129S2/SvPas * C57BL/6J	abnormal embryo development	J:184948
Tpx2^{Gt(D028B03)Wrst}/Tpx2⁺ involves: 129S2/SvPas * C57BL/6J	abnormal splenocyte morphology	J:184948
	aneuploidy	J:184948
	granulomatous inflammation	J:184948
	increased hepatocellular carcinoma incidence	J:184948
	increased intestinal adenoma incidence	J:184948
	increased lung adenocarcinoma incidence	J:184948
	increased lung adenoma incidence	J:184948
	increased lymphoma incidence	J:184948
	increased metastatic potential	J:184948
	increased stomach tumor incidence	J:184948
	pituitary intermediate lobe hyperplasia	J:184948
Tpx2^{Gt(D028B03)Wrst}/Tpx2^{Gt(D028B03)Wrst} involves: 129S2/SvPas * C57BL/6J	abnormal embryo development	J:184948
	abnormal mitotic spindle morphology	J:184948
	embryonic growth arrest	J:184948
	embryonic lethality, complete penetrance	J:184948
	polyploidy	J:184948

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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