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Ddhd2
Gene Detail
Symbol

Name
ID
Ddhd2
DDHD domain containing 2
MGI:1919358
Synonyms
2010305K11Rik, SAMWD1
Feature Type
protein coding gene
Genetic Map
Chromosome 8
14.17 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:25725324-25754280 bp, - strand
From Ensembl annotation of GRCm38

  28957 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:66646  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DDHD2
Gene Tree: Ddhd2

Human
homologs
DDHD2, DDHD domain containing 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 23259
neXtProt AC: NX_O94830

Human Synonyms: iPLA(1)gamma, SAMWD1, SPG54

Human Chr (Location): 8p11.23; chr8:38231343-38273885 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DDHD2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(7) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Ddhd2 interacts with 269 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process lipid catabolic process, lipid metabolic process, ...
Component cytoplasm, Golgi apparatus, ...
Function 1-oxa-2-oxocycloheptane lactonase activity, 3,4-dihydrocoumarin hydrolase activity, ...
External Resources: FuncBase
Expression
cDNA source data(45)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ddhd2    NEW 
Molecular
reagents
All nucleic(45) cDNA(45)
Microarray probesets(7)
Other database
links
Ensembl Gene Model ENSMUSG00000061313 (Evidence)
Entrez Gene 72108 (Evidence)
UniGene 246875
EC 3.1.1.-
Consensus CDS Project CCDS52529.1
International Mouse Phenotyping Consortium Status Ddhd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061313 Ensembl Gene Model | MGI Sequence Detail 28957 C57BL/6J ±  kb
transcript ENSMUST00000033975 Ensembl | MGI Sequence Detail 4267 Not Applicable 
polypeptide ENSMUSP00000033975 Ensembl | MGI Sequence Detail 699 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(21) UniProt(2)
Polymorphisms
SNPs within 2kb(154 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004177 DDHD
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR021129 Sterile alpha motif, type 1
InterPro IPR004170 WWE domain
Protein Ontology PR:000006344 phospholipase DDHD2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:212425 Baba T, et al., Phosphatidic acid (PA)-preferring phospholipase A1 regulates mitochondrial dynamics. J Biol Chem. 2014 Apr 18;289(16):11497-511
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory