Ddhd2^tm1Crv
Targeted Allele Detail

Summary

• Symbol: Ddhd2^tm1Crv
• Name: DDHD domain containing 2; targeted mutation 1, Benjamin F Cravatt
• MGI ID: MGI:5662251
• Gene: Ddhd2 Location: Chr8:26215351-26244502 bp, - strand Genetic Position: Chr8, 14.17 cM, cytoband A3
• Alliance: Ddhd2^tm1Crv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216446
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic region including exon 8 was replaced with a neo cassette via homologous recombination. RT-PCR analysis confirmed the absence of mRNA expression in brain tissue from homozygous mice. (J:216446)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ddhd2 Mutation: 40 strains or lines available

References

• Original: J:216446 Inloes JM, et al., The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14924-9
• All: 1 reference(s)