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Slc39a4 Gene Detail
Summary
  • Symbol
    Slc39a4
  • Name
    solute carrier family 39 (zinc transporter), member 4
  • Synonyms
    1600025H15Rik, AWMS2, zip4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919277
    NCBI Gene: 72027
  • Gene Overview
    MyGene.info: SLC39A4
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:76612383-76617379 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 36.16 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    20 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919277
protein coding gene Chr15:76612383-76617384 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022001
protein coding gene Chr15:76700232-76704659 (-)
A/J MGP_AJ_G0021959
protein coding gene Chr15:73897234-73901693 (-)
AKR/J MGP_AKRJ_G0021942
protein coding gene Chr15:75904962-75909433 (-)
BALB/cJ MGP_BALBcJ_G0021968
protein coding gene Chr15:73924452-73928911 (-)
C3H/HeJ MGP_C3HHeJ_G0021740
protein coding gene Chr15:75950087-75954546 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022408
protein coding gene Chr15:79565204-79569671 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019937
protein coding gene Chr15:70555072-70560103 (-)
CAST/EiJ MGP_CASTEiJ_G0021259
protein coding gene Chr15:76755645-76760154 (-)
CBA/J MGP_CBAJ_G0021707
protein coding gene Chr15:82080952-82085411 (-)
DBA/2J MGP_DBA2J_G0021832
protein coding gene Chr15:73436754-73441206 (-)
FVB/NJ MGP_FVBNJ_G0021812
protein coding gene Chr15:72492063-72496482 (-)
LP/J MGP_LPJ_G0021903
protein coding gene Chr15:76791247-76795635 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021837
protein coding gene Chr15:87419045-87427723 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022428
protein coding gene Chr15:76179321-76185035 (-)
PWK/PhJ MGP_PWKPhJ_G0021000
protein coding gene Chr15:73599804-73604568 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020840
protein coding gene Chr15:75872006-75876492 (-)
WSB/EiJ MGP_WSBEiJ_G0021311
protein coding gene Chr15:76267514-76271973 (-)



Homology
more
  • Human Ortholog
    SLC39A4, solute carrier family 39 member 4
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SLC39A4, solute carrier family 39 member 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AEZ, AWMS2, ZIP4
  • Links
    NCBI Gene ID: 55630
    neXtProt AC: NX_Q6P5W5
    UniProt: Q6P5W5

  • Chr Location
    8q24.3; chr8:144412414-144416895 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Slc39a4 mouse models; 1 with human SLC39A4 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 3 alleles in 3 genetic backgrounds
    3 images
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic letahlity around E10. Mice heterozygous for a null allele exhibit developmental defects similar to the teratology of zinc deficiency.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72027 NCBI Gene Model | MGI Sequence Detail 4997 C57BL/6J ±  kb
    transcript NM_028064 RefSeq | MGI Sequence Detail 2244 C57BL/6  
    polypeptide Q78IQ7 UniProt | EBI | MGI Sequence Detail 660 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      cDNA 51
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2146151
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 10
      Diseases 2
      Gene Ontology 8
      Phenotypes 36
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:254216 Bin BH, et al., Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10-p63 axis in epithelial homeostasis. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12243-12248

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory