Slc39a4
Gene Detail

Symbol Name ID

Slc39a4 solute carrier family 39 (zinc transporter), member 4 MGI:1919277

Synonyms

1600025H15Rik, AWMS2, zip4

Feature Type

protein coding gene

Genetic Map

Chromosome 15

36.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:76612385-76616852 bp, - strand From Ensembl annotation of GRCm38   4468 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:15638  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Slc39a4

Human homologs

Human Homolog		SLC39A4, solute carrier family 39 (zinc transporter), member 4
NCBI Gene ID		55630
neXtProt AC		NX_Q6P5W5
Human Synonyms		AEZ, AWMS2, ZIP4
Human Chr (Location)		8q24.3; chr8:145637798-145642273 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SLC39A4

Alleles and phenotypes

All alleles(12) : Targeted(4) Gene trapped(8)
 

Mice homozygous for a null allele exhibit embryonic letahlity around E10. Mice heterozygous for a null allele exhibit developmental defects similar to the teratology of zinc deficiency.

 
Human Diseases Modeled Using Mouse Slc39a4 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	cellular response to zinc ion starvation, cellular zinc ion homeostasis, ...
Component	apical plasma membrane, cytoplasmic membrane-bounded vesicle, ...
Function	metal ion transmembrane transporter activity, zinc ion transmembrane transporter activity

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (211)    Tissues (108)    Images (52)
Theiler Stages: 2, 3, 5, 11, 19, 22, 23, 28

Assay Type	Results
RNA in situ	164
In situ reporter (knock in)	5
Northern blot	6
RT-PCR	36

cDNA source data(49)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(52) cDNA(50) Primer pair(2)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000063354 (Evidence)
Entrez Gene	72027 (Evidence)
UniGene	276829
DFCI	TC1576727, TC1747276
DoTS	DT.102549591, DT.530780
NIA Mouse Gene Index	U231208
Consensus CDS Project	CCDS27578.1
International Mouse Knockout Project Status	Slc39a4

Sequences

Length	Strain/Species
genomic	ENSMUSG00000063354	Ensembl Gene Model | MGI Sequence Detail	4468	C57BL/6J
transcript	ENSMUST00000073428	Ensembl | MGI Sequence Detail	2224	Not Applicable
polypeptide	ENSMUSP00000073134	Ensembl | MGI Sequence Detail	660	Not Applicable

All sequences(25) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(16 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003689	Zinc/iron permease
Protein Ontology	PR:000015131	zinc transporter ZIP4

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:187178 Geiser J, et al., A mouse model of acrodermatitis enteropathica: loss of intestine zinc transporter ZIP4 (Slc39a4) disrupts the stem cell niche and intestine integrity. PLoS Genet. 2012 Jun;8(6):e1002766
All references(48)

Other accession IDs

MGI:2146151