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Slc39a4
Gene Detail
 Symbol
Name
ID
Slc39a4
solute carrier family 39 (zinc transporter), member 4
MGI:1919277
Synonyms 1600025H15Rik, AWMS2, zip4
Feature Type protein coding gene
Genetic Map
Chromosome 15
36.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:76612385-76616852 bp, - strand
From Ensembl annotation of GRCm38

  4468 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15638  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Slc39a4

Human
homologs
Human Homolog SLC39A4, solute carrier family 39 (zinc transporter), member 4
NCBI Gene ID 55630
neXtProt AC  NX_Q6P5W5
Human Synonyms  AEZ, AWMS2, ZIP4
Human Chr (Location)  8q24.3; chr8:144412414-144416895 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLC39A4
Alleles
and
phenotypes
All alleles(13) : Gene trapped(8) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit embryonic letahlity around E10. Mice heterozygous for a null allele exhibit developmental defects similar to the teratology of zinc deficiency.
 
Human Diseases Modeled Using Mouse Slc39a4 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cellular response to zinc ion starvation, cellular zinc ion homeostasis, ...
Component apical plasma membrane, cytoplasmic membrane-bounded vesicle, ...
Function metal ion transmembrane transporter activity, zinc ion transmembrane transporter activity
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (211)    Tissues (108)    Images (52)
Theiler Stages: 2, 3, 5, 11, 19, 22, 23, 28
Assay TypeResults
RNA in situ 164
In situ reporter (knock in) 5
Northern blot 6
RT-PCR 36
cDNA source data(49)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(52) cDNA(50) Primer pair(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000063354 (Evidence)
Entrez Gene72027 (Evidence)
UniGene276829
DFCITC1576727, TC1747276
DoTSDT.102549591, DT.530780
NIA Mouse Gene IndexU231208
Consensus CDS ProjectCCDS27578.1
International Mouse Knockout Project StatusSlc39a4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000063354 Ensembl Gene Model | MGI Sequence Detail 4468 C57BL/6J ±  kb
transcript ENSMUST00000073428 Ensembl | MGI Sequence Detail 2224 Not Applicable 
polypeptide ENSMUSP00000073134 Ensembl | MGI Sequence Detail 660 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003689 Zinc/iron permease
Protein Ontology PR:000015131 zinc transporter ZIP4
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:205936 Geiser J, et al., Clioquinol synergistically augments rescue by zinc supplementation in a mouse model of acrodermatitis enteropathica. PLoS One. 2013;8(8):e72543
All references(50)
Other
accession IDs
MGI:2146151

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/01/2014
MGI 5.18
The Jackson Laboratory