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Slc39a4
Gene Detail
Symbol

Name
ID
Slc39a4
solute carrier family 39 (zinc transporter), member 4
MGI:1919277
Synonyms
1600025H15Rik, AWMS2, zip4
Feature Type
protein coding gene
Genetic Map
Chromosome 15
36.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:76612385-76616852 bp, - strand
From Ensembl annotation of GRCm38

  4468 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15638  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: SLC39A4
Gene Tree: Slc39a4

Human
homologs
SLC39A4, solute carrier family 39 (zinc transporter), member 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 55630
neXtProt AC: NX_Q6P5W5

Human Synonyms: AEZ, AWMS2, ZIP4

Human Chr (Location): 8q24.3; chr8:144412414-144418034 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SLC39A4

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(8) Radiation induced(1) Targeted(6)
Genomic Mutations involving Slc39a4 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit embryonic letahlity around E10. Mice heterozygous for a null allele exhibit developmental defects similar to the teratology of zinc deficiency.
 
Human Diseases Modeled in Mice Using Slc39a4 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(5)
Interactions
Slc39a4 interacts with 34 markers (Mir15a, Mir15b, Mir16-1, ...)
Expression
Literature Summary: (8 records)
Data Summary: Results (211)    Tissues (108)    Images (52)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 164
In situ reporter (knock in) 5
Northern blot 6
RT-PCR 36
cDNA source data(49)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc39a4 ; ZFIN slc39a4    NEW 
Molecular
reagents
All nucleic(52) cDNA(50) Primer pair(2)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000063354 (Evidence)
Entrez Gene 72027 (Evidence)
UniGene 276829
DFCI TC1747276, TC1576727
DoTS DT.530780, DT.102549591
NIA Mouse Gene Index U231208
Consensus CDS Project CCDS27578.1
International Mouse Phenotyping Consortium Status Slc39a4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000063354 Ensembl Gene Model | MGI Sequence Detail 4468 C57BL/6J ±  kb
transcript ENSMUST00000073428 Ensembl | MGI Sequence Detail 2224 Not Applicable 
polypeptide ENSMUSP00000073134 Ensembl | MGI Sequence Detail 660 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003689 Zinc/iron permease
Protein Ontology PR:000015131 zinc transporter ZIP4
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:205936 Geiser J, et al., Clioquinol synergistically augments rescue by zinc supplementation in a mouse model of acrodermatitis enteropathica. PLoS One. 2013;8(8):e72543
All references(50)
Disease annotation references (2)
Other
accession IDs
MGI:2146151

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory