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Trmu
Gene Detail
Symbol

Name
ID
Trmu
tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
MGI:1919276
Synonyms
1110005N20Rik, 1600025P05Rik, Trmt1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
40.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:85879312-85897394 bp, + strand
From VEGA annotation of GRCm38

  18083 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5589  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TRMU
Protein SuperFamily: S-adenosyl-L-methionine dependent tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase
Gene Tree: Trmu

Human
homologs
TRMU, tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 55687
neXtProt AC: NX_O75648

Human Synonyms: LCAL3, MTO2, MTU1, TRMT, TRMT1, TRNT1

Human Chr (Location): 22q13; chr22:46335401-46357340 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human TRMU

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Radiation induced(1) Targeted(1)
Genomic Mutations involving Trmu (1)
Incidental mutations (data from Mutagenetix , APF )
Phenotype Images(2)
Interactions
Trmu interacts with 74 markers (Mir26a-1, Mir127, Mir133a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process tRNA methylation, tRNA processing, ...
Component mitochondrion
Function ATP binding, nucleotide binding, ...
External Resources: FuncBase
Expression
cDNA source data(36)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase trmu    NEW 
Molecular
reagents
All nucleic(38) cDNA(38)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000034977 (Evidence)
Ensembl Gene Model ENSMUSG00000022386 (Evidence)
Entrez Gene 72026 (Evidence)
UniGene 158211
DFCI TC1580950, TC1638439, TC1731314, TC1754200
DoTS DT.101721729, DT.40167398, DT.94148232
NIA Mouse Gene Index U016533
EC 2.8.1.-
Consensus CDS Project CCDS27726.1
International Mouse Phenotyping Consortium Status Trmu
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034977 VEGA Gene Model | MGI Sequence Detail 18083 C57BL/6J ±  kb
transcript OTTMUST00000088943 VEGA | MGI Sequence Detail 1526 Not Applicable 
polypeptide OTTMUSP00000048548 VEGA | MGI Sequence Detail 417 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(13) UniProt(4)
Polymorphisms
SNPs within 2kb(205 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023382 Adenine nucleotide alpha hydrolase-like domains
InterPro IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
InterPro IPR004506 tRNA-specific 2-thiouridylase
Protein Ontology PR:000016686 mitochondrial tRNA-specific 2-thiouridylase 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23
All references(30)
Other
accession IDs
MGI:1915704, MGI:2145971

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory