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Trmu Gene Detail
Summary
  • Symbol
    Trmu
  • Name
    tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
  • Synonyms
    1110005N20Rik, 1600025P05Rik, Trmt1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919276
    NCBI Gene: 72026
Location & Maps
more
  • Sequence Map
    Chr15:85879312-85897394 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18083 bp   ±  kb flank

  • Genome Browsers
Homology
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  • Human Ortholog
    TRMU, tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TRMU, tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LCAL3, MTO2, MTU1, TRMT, TRMT1, TRNT1
  • Links
    NCBI Gene ID: 55687
    neXtProt AC: NX_O75648

  • Chr Location
    22q13; chr22:46335401-46357340 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human TRMU associations

Human Disease Mouse Models
       Deafness, Aminoglycoside-Induced   OMIM: 580000
Liver Failure, Infantile, Transient; LFIT   OMIM: 613070
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    2
  • Targeted
    1
  • Genomic Mutations
    3 involving Trmu
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034977 VEGA Gene Model | MGI Sequence Detail 18083 C57BL/6J ±  kb
transcript OTTMUST00000088943 VEGA | MGI Sequence Detail 1526 Not Applicable  
polypeptide OTTMUSP00000048548 VEGA | MGI Sequence Detail 417 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    205 from dbSNP Build 137
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000016686 mitochondrial tRNA-specific 2-thiouridylase 1
  • EC
  • InterPro Domains
    IPR023382 Adenine nucleotide alpha hydrolase-like domains
    IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
    IPR004506 tRNA-specific 2-thiouridylase
Molecular
Reagents
less
  • All nucleic 38
    cDNA 38

    Microarray probesets 3
Other
Accession IDs
less
MGI:1915704, MGI:2145971
References
more
  • Summaries
    All 28
    Diseases 1
    Gene Ontology 6
    Phenotypes 21
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory