Trmu
Gene Detail

Symbol Name ID

Trmu tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase MGI:1919276

Synonyms

1110005N20Rik, 1600025P05Rik, Trmt1

Feature Type

protein coding gene

Genetic Map

Chromosome 15

40.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr15:85879312-85897394 bp, + strand From VEGA annotation of GRCm38   18083 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5589  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: S-adenosyl-L-methionine dependent tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase
Gene Tree: Trmu

Human homologs

Human Homolog		TRMU, tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
NCBI Gene ID		55687
neXtProt AC		NX_O75648
Human Synonyms		MTO2, MTU1, TRMT, TRMT1, TRNT1
Human Chr (Location)		22q13; chr22:46731298-46753237 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human TRMU

Alleles and phenotypes

All alleles(3) : Targeted(1) Gene trapped(2)

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	tRNA processing
Component	cytoplasm, mitochondrion
Function	ATP binding, nucleotide binding, ...

External Resources: FuncBase

Expression

cDNA source data(36)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(38) cDNA(38)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000034977 (Evidence)
Ensembl Gene Model	ENSMUSG00000022386 (Evidence)
Entrez Gene	72026 (Evidence)
UniGene	158211
DFCI	TC1580950, TC1638439, TC1731314, TC1754200
DoTS	DT.101721729, DT.40167398, DT.94148232
NIA Mouse Gene Index	U016533
EC	2.8.1.-
Consensus CDS Project	CCDS27726.1
International Mouse Knockout Project Status	Trmu

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034977	VEGA Gene Model | MGI Sequence Detail	18083	C57BL/6J
transcript	OTTMUST00000088943	VEGA | MGI Sequence Detail	1526	Not Applicable
polypeptide	OTTMUSP00000048548	VEGA | MGI Sequence Detail	417	Not Applicable

All sequences(56) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(103 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023382	Adenine nucleotide alpha hydrolase-like domains
InterPro	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold
InterPro	IPR004506	tRNA-specific 2-thiouridylase
Protein Ontology	PR:000016686	mitochondrial tRNA-specific 2-thiouridylase 1

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23
All references(32)

Other accession IDs

MGI:1915704, MGI:2145971