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Atad3a Gene Detail
Summary
  • Symbol
    Atad3a
  • Name
    ATPase family, AAA domain containing 3A
  • Synonyms
    2400004H09Rik, Tob3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919214
    NCBI Gene: 108888
Location & Maps
more
  • Sequence Map
    Chr4:155740641-155761093 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20453 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 87.20 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ATAD3A, ATPase family, AAA domain containing 3A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ATAD3A, ATPase family, AAA domain containing 3A
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 55210
    neXtProt AC: NX_Q9NVI7

  • Chr Location
    1p36.33; chr1:1512143-1534687 (+)  GRCh38.p2

  • Human Ortholog
    ATAD3B, ATPase family, AAA domain containing 3B
    Orthology source: HGNC
  • Synonyms
    AAA-TOB3, TOB3
  • Links
    NCBI Gene ID: 83858
    neXtProt AC: NX_Q5T9A4

  • Chr Location
    1p36.33; chr1:1471732-1509479 (+)  GRCh38.p2

  • Human Ortholog
    ATAD3C, ATPase family, AAA domain containing 3C
    Orthology source: HGNC
  • Links
    NCBI Gene ID: 219293
    neXtProt AC: NX_Q5T2N8

  • Chr Location
    1p36.33; chr1:1441301-1470158 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Gene trapped
    5
  • Targeted
    2
  • Incidental Mutations
Mice homozygous for a gene trapped allele die around E7.5 exhibiting growth retardation, failure to gastrulate, and impaired development of the trophoblast lineage immediately after implantation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010851 VEGA Gene Model | MGI Sequence Detail 20453 C57BL/6J ±  kb
transcript OTTMUST00000025387 VEGA | MGI Sequence Detail 2413 Not Applicable  
polypeptide OTTMUSP00000011641 VEGA | MGI Sequence Detail 591 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    156 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000030707 ATPase family AAA domain-containing protein 3A
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR003959 ATPase, AAA-type, core
    IPR021911 ATPase family AAA domain-containing protein 3, domain of unknown function DUF3523
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 116
    cDNA 115
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:207851 Li S, et al., Expression analysis of ATAD3 isoforms in rodent and human cell lines and tissues. Gene. 2014 Feb 1;535(1):60-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory