Atad3a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Atad3a
ATPase family, AAA domain containing 3A
MGI:1919214

35 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Atad3a^{Gt(E118D03)Wrst}/Atad3a^{Gt(E118D03)Wrst} involves: 129P2/OlaHsd * C57BL/6J	abnormal developmental patterning	J:195793
	abnormal ectoderm development	J:195793
	abnormal ectoplacental cone morphology	J:195793
	abnormal embryo development	J:195793
	abnormal endoderm development	J:195793
	abnormal extraembryonic ectoderm morphology	J:195793
	abnormal proximal-distal axis patterning	J:195793
	abnormal trophectoderm morphology	J:195793
	absent ectoplacental cone	J:195793
	absent extraembryonic ectoderm	J:195793
	embryonic growth retardation	J:195793
	embryonic lethality between implantation and placentation, complete penetrance	J:195793
	failure to gastrulate	J:195793
	small embryonic epiblast	J:195793
Atad3a^{tm1a(KOMP)Wtsi}/Atad3a⁺ C57BL/6N-Atad3a^{tm1a(KOMP)Wtsi}/Wtsi	decreased circulating cholesterol level	J:211773
	decreased circulating HDL cholesterol level	J:211773
Atad3a^{tm1a(KOMP)Wtsi}/Atad3a^{tm1a(KOMP)Wtsi} C57BL/6N-Atad3a^{tm1a(KOMP)Wtsi}/Wtsi	preweaning lethality, complete penetrance	J:211773
Atad3a^{tm1c(KOMP)Wtsi}/Atad3a^{tm1c(KOMP)Wtsi} Myl1^tm1(cre)Sjb/Myl1⁺ B6J.Cg-Myl1^tm1(cre)Sjb Atad3a^{tm1c(KOMP)Wtsi}	abnormal cholesterol homeostasis	J:263681
	abnormal mitochondrial crista morphology	J:263681
	abnormal motor coordination/balance	J:263681
	abnormal muscle fiber mitochondrial morphology	J:263681
	abnormal muscle fiber morphology	J:263681
	abnormal oxidative phosphorylation	J:263681
	cachexia	J:263681
	decreased grip strength	J:263681
	decreased locomotor activity	J:263681
	decreased mitochondrial size	J:263681
	decreased skeletal muscle fiber mitochondrial DNA content	J:263681
	decreased skeletal muscle weight	J:263681
	disorganized mitochondrial cristae	J:263681
	normal growth/size/body region phenotype	J:263681
	kyphosis	J:263681
	skeletal muscle fiber atrophy	J:263681
	skeletal muscle fiber degeneration	J:263681
	weakness	J:263681

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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