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Myh14 Gene Detail
Summary
  • Symbol
    Myh14
  • Name
    myosin, heavy polypeptide 14
  • Synonyms
    2400004E04Rik, NMHC II-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919210
    NCBI Gene: 71960
  • Gene Overview
    MyGene.info: MYH14
Location & Maps
more
  • Sequence Map
    Chr7:44605803-44670843 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      65041 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 28.85 cM, cytoband B2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MYH14, myosin heavy chain 14
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MYH14, myosin heavy chain 14
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DFNA4, DFNA4A, FP17425, MHC16, MYH17, myosin, NMHC II-C, NMHC-II-C, PNMHH
  • Links
    NCBI Gene ID: 79784
    neXtProt AC: NX_Q7Z406

  • Chr Location
    19q13.33; chr19:50188186-50310544 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human MYH14 associations

Human Disease Mouse Models
       Deafness, Autosomal Dominant 4A; DFNA4A   OMIM: 600652
Peripheral Neuropathy, Myopathy, Hoarseness, and Hearing Loss; PNMHH   OMIM: 614369
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    3
  • Targeted
    5
  • Incidental Mutations
Mice homozygous for a knock-out allele are healthy and survive to adulthood with no apparent defects. About 30% of knock-in mice either heterozygous or homozygous for a single amino acid mutation exhibit increased lymphoma incidence.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017593 VEGA Gene Model | MGI Sequence Detail 65041 C57BL/6J ±  kb
transcript OTTMUST00000113906 VEGA | MGI Sequence Detail 6499 Not Applicable  
polypeptide OTTMUSP00000063619 VEGA | MGI Sequence Detail 2033 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    643 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 42
    cDNA 40
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 48
    Developmental Gene Expression 13
    Gene Ontology 9
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:222409 Kim S, et al., Convergence and extrusion are required for normal fusion of the mammalian secondary palate. PLoS Biol. 2015 Apr;13(4):e1002122

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory