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Myh14
Gene Detail
 Symbol
Name
ID
Myh14
myosin, heavy polypeptide 14
MGI:1919210
Synonyms 2400004E04Rik, NMHC II-C
Feature Type protein coding gene
Genetic Map
Chromosome 7
28.85 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:44605803-44670843 bp, - strand
From VEGA annotation of GRCm38

  65041 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23480  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Myh14

Human
homologs
Human Homolog MYH14, myosin, heavy chain 14, non-muscle
NCBI Gene ID 79784
neXtProt AC  NX_Q7Z406
Human Synonyms  DFNA4, DFNA4A, MHC16, MYH17, myosin, NMHC II-C, NMHC-II-C, PNMHH
Human Chr (Location)  19q13.33; chr19:50203628-50310545 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human MYH14
Alleles
and
phenotypes
All alleles(8) : Targeted(5) Gene trapped(3)
 
Mice homozygous for a knock-out allele are healthy and survive to adulthood with no apparent defects. About 30% of knock-in mice either heterozygous or homozygous for a single amino acid mutation exhibit increased lymphoma incidence.
 
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process actin filament-based movement, actomyosin structure organization, ...
Component actomyosin, axon, ...
Function actin binding, actin-dependent ATPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (121)    Tissues (38)    Images (28)
Theiler Stages: 20, 23, 24, 28
Assay TypeResults
RNA in situ 88
Western blot 1
RT-PCR 32
cDNA source data(40)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(42) cDNA(40) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000017593 (Evidence)
Ensembl Gene ModelENSMUSG00000030739 (Evidence)
Entrez Gene71960 (Evidence)
UniGene158289
DFCITC1582128, TC1624335
DoTSDT.101723482, DT.40143047, DT.91327954
NIA Mouse Gene IndexU028495
Consensus CDS ProjectCCDS39943.1
International Mouse Knockout Project StatusMyh14
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017593 VEGA Gene Model | MGI Sequence Detail 65041 C57BL/6J ±  kb
transcript OTTMUST00000113906 VEGA | MGI Sequence Detail 6499 Not Applicable 
polypeptide OTTMUSP00000063619 VEGA | MGI Sequence Detail 2033 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(18) UniProt(4)
Polymorphisms SNPs within 2kb(654 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001609 Myosin head, motor domain
InterPro IPR027401 Myosin-like IQ motif-containing domain
InterPro IPR004009 Myosin, N-terminal, SH3-like
InterPro IPR008989 Myosin S1 fragment, N-terminal
InterPro IPR002928 Myosin tail
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010824 myosin-14
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:198338 Ebrahim S, et al., NMII forms a contractile transcellular sarcomeric network to regulate apical cell junctions and tissue geometry. Curr Biol. 2013 Apr 22;23(8):731-6
All references(46)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory