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Nanog Gene Detail
Summary
  • Symbol
    Nanog
  • Name
    Nanog homeobox
  • Synonyms
    2410002E02Rik, ecat4, ENK
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919200
    NCBI Gene: 71950
  • Gene Overview
    MyGene.info: NANOG
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:122707489-122714633 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 57.80 cM, cytoband F2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    44 from dbSNP Build 142
  • Strain Annotations
    11
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919200
protein coding gene Chr6:122706483-122714633 (.)
129S1/SvImJ no annotation
A/J no annotation
AKR/J MGP_AKRJ_G0031130
protein coding gene Chr6:124398175-124405584 (+)
BALB/cJ MGP_BALBcJ_G0031210
protein coding gene Chr6:120756364-120771025 (+)
C3H/HeJ MGP_C3HHeJ_G0030929
protein coding gene Chr6:124357247-124366697 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031669
protein coding gene Chr6:129139306-129148792 (+)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0031001
protein coding gene Chr6:118923296-118930348 (+)
LP/J MGP_LPJ_G0031129
protein coding gene Chr6:126005973-126015072 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031036
protein coding gene Chr6:138126523-138133632 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031699
protein coding gene Chr6:124293239-124301885 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0029860
protein coding gene Chr6:122433156-122439479 (+)
WSB/EiJ MGP_WSBEiJ_G0035000
protein coding gene ChrX:84669227-84670321 (-)



Homology
more
  • Human Ortholog
    NANOG, Nanog homeobox
  • Vertebrate Orthologs
    7
  • Human Ortholog
    NANOG, Nanog homeobox
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 79923
    neXtProt AC: NX_Q9H9S0
    UniProt: Q9H9S0

  • Chr Location
    12p13.31; chr12:7789396-7796061 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene die between E3.5 and E5.5 with abnormal embryonic and extraembryonic tissue development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000012396 Ensembl Gene Model | MGI Sequence Detail 7145 C57BL/6J ±  kb
    transcript ENSMUST00000012540 Ensembl | MGI Sequence Detail 2211 Not Applicable  
    polypeptide ENSMUSP00000012540 Ensembl | MGI Sequence Detail 305 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 17
      Primer pair 16
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 288
      Developmental Gene Expression 156
      Gene Ontology 44
      Phenotypes 20
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:264612 Morgani SM, et al., A Sprouty4 reporter to monitor FGF/ERK signaling activity in ESCs and mice. Dev Biol. 2018 Sep 1;441(1):104-126

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.
    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory