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Nanog
Gene Detail
Symbol

Name
ID
Nanog
Nanog homeobox
MGI:1919200
Synonyms
2410002E02Rik, ecat4, ENK
Feature Type
protein coding gene
Genetic Map
Chromosome 6
57.80 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:122707489-122714633 bp, + strand
From VEGA annotation of GRCm38

  7145 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:78027  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: NANOG
Gene Tree: Nanog

Human
homologs
NANOG, Nanog homeobox
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 79923
neXtProt AC: NX_Q9H9S0

Human Chr (Location): 12p13.31; chr12:7788426-7796061 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(21) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a disruption in this gene die between E3.5 and E5.5 with abnormal embryonic and extraembryonic tissue development.
 
Interactions
Nanog interacts with 142 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process cell proliferation, embryo development, ...
Component nucleolus, nucleoplasm, ...
Function chromatin binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (112 records)
Data Summary: Results (377)    Tissues (146)    Images (73)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 38
RNA in situ 109
In situ reporter (knock in) 6
Northern blot 63
RT-PCR 161
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN nanog    NEW 
Molecular
reagents
All nucleic(31) cDNA(16) Primer pair(14) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000023511 (Evidence)
Ensembl Gene Model ENSMUSG00000012396 (Evidence)
Entrez Gene 71950 (Evidence)
DFCI TC1579485
DoTS DT.102548796, DT.103579263, DT.483724
NIA Mouse Gene Index U007377, U125018
PDB 2VI6
Consensus CDS Project CCDS39623.1, CCDS80607.1
International Mouse Phenotyping Consortium Status Nanog
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023511 VEGA Gene Model | MGI Sequence Detail 7145 C57BL/6J ±  kb
transcript OTTMUST00000057270 VEGA | MGI Sequence Detail 2211 Not Applicable 
polypeptide OTTMUSP00000027613 VEGA | MGI Sequence Detail 305 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(16) UniProt(4)
Polymorphisms
SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeobox domain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000010968 homeobox protein NANOG
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:222493 Yamaguchi YL, et al., Sall4 is essential for mouse primordial germ cell specification by suppressing somatic cell program genes. Stem Cells. 2015 Jan;33(1):289-300
All references(200)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory