Nanog
Gene Detail

Symbol Name ID

Nanog Nanog homeobox MGI:1919200

Synonyms

2410002E02Rik, ecat4, ENK

Feature Type

protein coding gene

Genetic Map

Chromosome 6

57.80 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr6:122707489-122714633 bp, + strand From VEGA annotation of GRCm38   7145 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:78027  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Gene Tree: Nanog

Human homologs

Human Homolog		NANOG, Nanog homeobox
NCBI Gene ID		79923
neXtProt AC		NX_Q9H9S0
Human Chr (Location)		12p13.31; chr12:7941995-7948655 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(27) : Targeted(6) Gene trapped(21)
 

Mice homozygous for a disruption in this gene die between E3.5 and E5.5 with abnormal embryonic and extraembryonic tissue development.

 

Gene Ontology (GO) classifications

All GO classifications: (47 annotations)

Process	cell proliferation, embryo development, ...
Component	nucleolus, nucleoplasm, ...
Function	chromatin binding, DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (79 records)
Data Summary: Results (330)    Tissues (131)    Images (55)
Theiler Stages: 1, 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	36
RNA in situ	95
In situ reporter (knock in)	6
Northern blot	49
RT-PCR	144

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) cDNA(14) Primer pair(12) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000023511 (Evidence)
Ensembl Gene Model	ENSMUSG00000012396 (Evidence)
Entrez Gene	71950 (Evidence)
DFCI	TC1579485
DoTS	DT.102548796, DT.103579263, DT.483724
NIA Mouse Gene Index	U007377, U125018
PDB	2VI6
Consensus CDS Project	CCDS39623.1
International Mouse Knockout Project Status	Nanog

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023511	VEGA Gene Model | MGI Sequence Detail	7145	C57BL/6J
transcript	OTTMUST00000057270	VEGA | MGI Sequence Detail	2211	Not Applicable
polypeptide	OTTMUSP00000027613	VEGA | MGI Sequence Detail	305	Not Applicable

All sequences(44) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(27 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
Protein Ontology	PR:000010968	homeobox protein NANOG

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194075 Guenatri M, et al., Plasticity in Dnmt3L-dependent and -independent modes of de novo methylation in the developing mouse embryo. Development. 2013 Feb 1;140(3):562-72
All references(156)