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Nanog
Gene Detail
Symbol

Name
ID
Nanog
Nanog homeobox
MGI:1919200
Synonyms
2410002E02Rik, ecat4, ENK
Feature Type
protein coding gene
Genetic Map
Chromosome 6
57.80 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:122707489-122714633 bp, + strand
From VEGA annotation of GRCm38

  7145 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:78027  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Nanog

Human
homologs
Human Homolog NANOG, Nanog homeobox
NCBI Gene ID 79923
neXtProt AC  NX_Q9H9S0
Human Chr (Location)  12p13.31; chr12:7789399-7796059 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(21) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a disruption in this gene die between E3.5 and E5.5 with abnormal embryonic and extraembryonic tissue development.
 
Interactions
Nanog interacts with 142 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process cell proliferation, embryo development, ...
Component nucleolus, nucleoplasm, ...
Function chromatin binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (97 records)
Data Summary: Results (377)    Tissues (146)    Images (73)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 38
RNA in situ 109
In situ reporter (knock in) 6
Northern blot 63
RT-PCR 161
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) cDNA(16) Primer pair(14) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000023511 (Evidence)
Ensembl Gene ModelENSMUSG00000012396 (Evidence)
Entrez Gene71950 (Evidence)
DFCITC1579485
DoTSDT.102548796, DT.103579263, DT.483724
NIA Mouse Gene IndexU007377, U125018
PDB2VI6
Consensus CDS ProjectCCDS39623.1
International Mouse Knockout Project StatusNanog
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023511 VEGA Gene Model | MGI Sequence Detail 7145 C57BL/6J ±  kb
transcript OTTMUST00000057270 VEGA | MGI Sequence Detail 2211 Not Applicable 
polypeptide OTTMUSP00000027613 VEGA | MGI Sequence Detail 305 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(10) UniProt(4)
Polymorphisms
SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000010968 homeobox protein NANOG
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:208425 Le Bin GC, et al., Oct4 is required for lineage priming in the developing inner cell mass of the mouse blastocyst. Development. 2014 Mar;141(5):1001-10
All references(181)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory