Automated description from the Alliance of Genome Resources (Release 9.0.0)
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including cell dedifferentiation; positive regulation of transcription by RNA polymerase II; and regulation of stem cell division. Acts upstream of or within several processes, including negative regulation of BMP signaling pathway; negative regulation of transcription by RNA polymerase II; and response to retinoic acid. Located in nucleoplasm. Is active in chromatin. Is expressed in several structures, including 4-8 cell stage conceptus; alimentary system; blastocyst-stage conceptus; central nervous system; and genitourinary system. Orthologous to several human genes including NANOG (Nanog homeobox).
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