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Mad2l2
Gene Detail
Symbol

Name
ID
Mad2l2
MAD2 mitotic arrest deficient-like 2
MGI:1919140
Synonyms
2310033C13Rik, G1-453-4, MAD2B, repro22, REV7
Feature Type
protein coding gene
Genetic Map
Chromosome 4
78.67 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:148130384-148145699 bp, + strand
From VEGA annotation of GRCm38

  15316 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4624  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: mitotic spindle assembly checkpoint protein MAD2A
Gene Tree: Mad2l2

Human
homologs
Human Homolog MAD2L2, MAD2 mitotic arrest deficient-like 2 (yeast)
NCBI Gene ID 10459
neXtProt AC  NX_Q9UI95
Human Synonyms  MAD2B, POLZ2, REV7
Human Chr (Location)  1p36; chr1:11674480-11691621 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit partial lethality between E13.5 and after birth, reduced body size, female and male infertility, atrophy of the testis and ovaries, apoptosis of primordial germ cells, forebrain neuroblast apoptosis and accumulation of double strand breaks.
 
Interactions
Mad2l2 interacts with 52 markers (Mir20a, Mir26a-2, Mir26b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process actin filament organization, cell cycle, ...
Component anaphase-promoting complex, cytoplasm, ...
Function JUN kinase binding, RNA polymerase II activating transcription factor binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (60)    Tissues (11)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 58
RT-PCR 2
cDNA source data(46)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(47) cDNA(46) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000010954 (Evidence)
Ensembl Gene ModelENSMUSG00000029003 (Evidence)
Entrez Gene71890 (Evidence)
UniGene9648
DFCITC1594612, TC1579800
DoTSDT.101141834, DT.530243, DT.94395653
NIA Mouse Gene IndexU005083
PDB4FJO
Consensus CDS ProjectCCDS18932.1
International Mouse Knockout Project StatusMad2l2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010954 VEGA Gene Model | MGI Sequence Detail 15316 C57BL/6J ±  kb
transcript OTTMUST00000025697 VEGA | MGI Sequence Detail 1162 Not Applicable 
polypeptide OTTMUSP00000011781 VEGA | MGI Sequence Detail 211 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(29) UniProt(7)
Polymorphisms
SNPs within 2kb(215 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003511 DNA-binding HORMA
Protein Ontology PR:000010040 mitotic spindle assembly checkpoint protein MAD2B
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:209515 Khalaj M, et al., A missense mutation in Rev7 disrupts formation of Polzeta, impairing mouse development and repair of genotoxic agent-induced DNA lesions. J Biol Chem. 2014 Feb 7;289(6):3811-24
All references(38)
Other
accession IDs
MGI:3512803

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory