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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mad2l2
MAD2 mitotic arrest deficient-like 2
MGI:1919140
49 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mad2l2repro22/Mad2l2repro22
C3.B6(Cg)-Mad2l2repro22 		absent germ cells J:209515
absent ovarian follicles J:209515
normal cellular phenotype J:209515
decreased cell proliferation J:209515
decreased enterocyte cell number J:209515
decreased primordial germ cell number J:209515
embryonic lethality, incomplete penetrance J:209515
female infertility J:209515
increased enterocyte apoptosis J:209515
male infertility J:209515
prenatal growth retardation J:209515
normal reproductive system phenotype J:209515
small ovary J:209515
small testis J:209515
Mad2l2repro22/Mad2l2repro22
involves: C3HeB/FeJ * C57BL/6J 		absent ovarian follicles J:92463
arrest of spermatogenesis J:92463
azoospermia J:92463
decreased male germ cell number J:92463
decreased oocyte number J:92463
decreased testis weight J:92463
female infertility J:92463
male infertility J:92463
small ovary J:92463
Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz
involves: 129S2/SvPas * BALB/cJ 		abnormal cell cycle J:223048
abnormal epigenetic regulation of gene expression J:223048
abnormal ovary morphology J:223048
abnormal primordial germ cell migration J:223048
abnormal primordial germ cell morphology J:223048
abnormal seminiferous tubule morphology J:223048
abnormal Sertoli cell morphology J:223048
absent germ cells J:223048
absent ovarian follicles J:223048
absent ovary J:223048
absent primordial germ cells J:223048
decreased body size J:223048
decreased body weight J:223048
decreased embryo size J:223048
decreased fetal size J:223048
decreased primordial germ cell number J:223048
ectopic Sertoli cells J:223048
female infertility J:223048
increased Leydig cell number J:223048
increased primordial germ cell apoptosis J:223048
lethality during fetal growth through weaning, incomplete penetrance J:223048
male infertility J:223048
postnatal growth retardation J:223048
slow postnatal weight gain J:223048
small gonad J:223048
small ovary J:223048
small testis J:223048
Mad2l2tm1Mpz/Mad2l2tm1Mpz
Tg(Prdm1-cre)1Masu/0
involves: 129S2/SvPas * C57BL/6 * CBA 		abnormal primordial germ cell apoptosis J:223048
Mad2l2tm1Ymu/Mad2l2tm1Ymu
involves: 129 * C57BL/6J 		abnormal double-strand DNA break repair J:198275
abnormal oogenesis J:198275
abnormal spermatogenesis J:198275
absent ovarian follicles J:198275
absent primordial germ cells J:198275
azoospermia J:198275
decreased birth body size J:198275
decreased body size J:198275
decreased body weight J:198275
decreased embryo size J:198275
decreased primordial germ cell number J:198275
decreased testis weight J:198275
female infertility J:198275
increased forebrain apoptosis J:198275
increased primordial germ cell apoptosis J:198275
lethality during fetal growth through weaning, incomplete penetrance J:198275
male infertility J:198275
normal nervous system phenotype J:198275
ovary atrophy J:198275
seminiferous tubule degeneration J:198275
small ovary J:198275
small testis J:198275
weakness J:198275
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory