Mad2l2^tm1.1Mpz
Targeted Allele Detail

Summary

• Symbol: Mad2l2^tm1.1Mpz
• Name: MAD2 mitotic arrest deficient-like 2; targeted mutation 1.1, Mehdi Pirouz
• MGI ID: MGI:5704065
• Synonyms: Mad2l2^-
• Gene: Mad2l2 Location: Chr4:148214841-148230156 bp, + strand Genetic Position: Chr4, 78.67 cM, cytoband E1
• Alliance: Mad2l2^tm1.1Mpz page

Small size of Mad2l2^tm1.1Mpz/Mad2l2^tm1.1Mpz mutants

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223048
• Parent Cell Line: MPI-II (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 8. Cre-mediated recombination removed exons 1 through 8 and the selection cassette. (J:223048)

Generation of the Mad2l2^tm1Mpz and Mad2l2^tm1.1Mpz aleles

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mad2l2 Mutation: 14 strains or lines available

References

• Original: J:223048 Pirouz M, et al., A critical function of Mad2l2 in primordial germ cell development of mice. PLoS Genet. 2013 Aug;9(8):e1003712
• All: 2 reference(s)