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Chit1
Gene Detail
Symbol

Name
ID
Chit1
chitinase 1 (chitotriosidase)
MGI:1919134
Synonyms
2300002L19Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 1
58.12 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:134111242-134151540 bp, + strand
From VEGA annotation of GRCm38

  40299 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68318  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 western clawed frog

HCOP human homology predictions: CHIT1
Protein SuperFamily: chitinase-like protein
Gene Tree: Chit1

Human
homologs
CHIT1, chitinase 1 (chitotriosidase)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1118
neXtProt AC: NX_Q13231

Human Synonyms: CHI3, CHIT, CHITD

Human Chr (Location): 1q32.1; chr1:203212823-203230099 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CHIT1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced pulmonary fibrosis induced by bleomycin or IL13 expression.
 
Interactions
Chit1 interacts with 14 markers (Mir15a, Mir92-2, Mir212, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process carbohydrate metabolic process, chitin catabolic process, ...
Component extracellular region, extracellular space, ...
Function chitinase activity, chitin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(8) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021755 (Evidence)
Ensembl Gene Model ENSMUSG00000026450 (Evidence)
Entrez Gene 71884 (Evidence)
UniGene 328268
DFCI TC1588236, TC1595611
DoTS DT.102555201, DT.50316116
NIA Mouse Gene Index U000822
EC 3.2.1.14
Consensus CDS Project CCDS15304.1, CCDS69943.1
International Mouse Phenotyping Consortium Status Chit1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021755 VEGA Gene Model | MGI Sequence Detail 40299 C57BL/6J ±  kb
transcript OTTMUST00000051642 VEGA | MGI Sequence Detail 1815 Not Applicable 
polypeptide OTTMUSP00000024343 VEGA | MGI Sequence Detail 464 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(12) UniProt(2)
Polymorphisms
SNPs within 2kb(301 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011583 Chitinase II
InterPro IPR029070 Chitinase insertion domain
InterPro IPR002557 Chitin binding domain
InterPro IPR013781 Glycoside hydrolase, catalytic domain
InterPro IPR001579 Glycoside hydrolase, chitinase active site
InterPro IPR001223 Glycoside hydrolase family 18, catalytic domain
InterPro IPR017853 Glycoside hydrolase superfamily
Protein Ontology PR:000005426 chitotriosidase-1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:189872 Lee CG, et al., Chitinase 1 is a biomarker for and therapeutic target in scleroderma-associated interstitial lung disease that augments TGF-beta1 signaling. J Immunol. 2012 Sep 1;189(5):2635-44
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory