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Chit1 Gene Detail
Summary
  • Symbol
    Chit1
  • Name
    chitinase 1 (chitotriosidase)
  • Synonyms
    2300002L19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919134
    NCBI Gene: 71884
Location & Maps
more
  • Sequence Map
    Chr1:134111242-134151540 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40299 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 58.12 cM, cytoband E4
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CHIT1, chitinase 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CHIT1, chitinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CHI3, CHIT, CHITD
  • Links
    NCBI Gene ID: 1118
    neXtProt AC: NX_Q13231

  • Chr Location
    1q32.1; chr1:203212823-203230099 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CHIT1 associations

Human Disease Mouse Models
       Chitotriosidase Deficiency; CHITD   OMIM: 614122
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    3 involving Chit1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit reduced pulmonary fibrosis induced by bleomycin or IL13 expression.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021755 VEGA Gene Model | MGI Sequence Detail 40299 C57BL/6J ±  kb
transcript OTTMUST00000051642 VEGA | MGI Sequence Detail 1815 Not Applicable  
polypeptide OTTMUSP00000024343 VEGA | MGI Sequence Detail 464 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    298 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:189872 Lee CG, et al., Chitinase 1 is a biomarker for and therapeutic target in scleroderma-associated interstitial lung disease that augments TGF-beta1 signaling. J Immunol. 2012 Sep 1;189(5):2635-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory