Tmprss6
Gene Detail

Symbol Name ID

Tmprss6 transmembrane serine protease 6 MGI:1919003

Synonyms

1300008A22Rik, matriptase-2

Feature Type

protein coding gene

Genetic Map

Chromosome 15

37.49 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:78439668-78468634 bp, - strand From Ensembl annotation of GRCm38   28967 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:12408  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: matriptase-2
Gene Tree: Tmprss6

Human homologs

Human Homolog		TMPRSS6, transmembrane protease, serine 6
NCBI Gene ID		164656
neXtProt AC		NX_Q8IU80
Human Synonyms		IRIDA
Human Chr (Location)		22q12.3; chr22:37461479-37499693 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TMPRSS6

Alleles and phenotypes

All alleles(11) : Targeted(6) Gene trapped(2) Chemically induced(3)
 

Homozygosity for an inactivating mutation of this gene results in hair loss over the entire body except the face, microcytic anemia and female infertility, all reversible by dietary iron supplementation.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	fibrinolysis, iron ion homeostasis, ...
Component	integral to membrane, membrane, ...
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
cDNA source data(66)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(66) cDNA(66)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000016942 (Evidence)
Entrez Gene	71753 (Evidence)
UniGene	34056
DFCI	TC1579967
DoTS	DT.101297023, DT.489908
NIA Mouse Gene Index	U036382
EC	3.4.21.-
Consensus CDS Project	CCDS37133.1
International Mouse Knockout Project Status	Tmprss6

Sequences

Length	Strain/Species
genomic	ENSMUSG00000016942	Ensembl Gene Model | MGI Sequence Detail	28967	C57BL/6J
transcript	ENSMUST00000017086	Ensembl | MGI Sequence Detail	3191	Not Applicable
polypeptide	ENSMUSP00000017086	Ensembl | MGI Sequence Detail	811	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(153 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000859	CUB
InterPro	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR017118	Peptidase S1A, matriptase-2
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site
InterPro	IPR000082	SEA
Protein Ontology	PR:000016460	transmembrane protease serine 6

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:185154 Nai A, et al., Deletion of TMPRSS6 attenuates the phenotype in a mouse model of beta-thalassemia. Blood. 2012 May 24;119(21):5021-9
All references(48)