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Arhgef3 Gene Detail
Summary
  • Symbol
    Arhgef3
  • Name
    Rho guanine nucleotide exchange factor (GEF) 3
  • Synonyms
    1200004I24Rik, 9830169H03Rik, C76747
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918954
    NCBI Gene: 71704
  • Gene Overview
    MyGene.info: ARHGEF3
Location & Maps
more
  • Sequence Map
    Chr14:27238039-27403904 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      165866 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 16.09 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ARHGEF3, Rho guanine nucleotide exchange factor 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ARHGEF3, Rho guanine nucleotide exchange factor 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GEF3, STA3, XPLN
  • Links
    NCBI Gene ID: 50650
    neXtProt AC: NX_Q9NR81

  • Chr Location
    3p14.3; chr3:56727418-57079308 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    92
  • Gene trapped
    90
  • Targeted
    2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021895 Ensembl Gene Model | MGI Sequence Detail 165866 C57BL/6J ±  kb
transcript ENSMUST00000049206 Ensembl | MGI Sequence Detail 3585 Not Applicable  
polypeptide ENSMUSP00000046486 Ensembl | MGI Sequence Detail 531 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1861 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000004256 rho guanine nucleotide exchange factor 3
  • PDB
  • InterPro Domains
    IPR000219 Dbl homology (DH) domain
    IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
    IPR011993 PH domain-like
    IPR001849 Pleckstrin homology domain
Molecular
Reagents
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  • All nucleic 81
    cDNA 81

    Microarray probesets 3
Other
Accession IDs
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MGI:1353572, MGI:2442908
References
more
  • Summaries
    All 39
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory