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Arhgef3 Gene Detail
Summary
  • Symbol
    Arhgef3
  • Name
    Rho guanine nucleotide exchange factor (GEF) 3
  • Synonyms
    1200004I24Rik, 9830169H03Rik, C76747
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918954
    NCBI Gene: 71704
  • Gene Overview
    MyGene.info: ARHGEF3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:27114899-27403911 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      289013 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 16.09 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ARHGEF3, Rho guanine nucleotide exchange factor 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ARHGEF3, Rho guanine nucleotide exchange factor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GEF3, STA3, XPLN
  • Links
    NCBI Gene ID: 50650
    neXtProt AC: NX_Q9NR81
    UniProt: Q9NR81

  • Chr Location
    3p14.3; chr3:56727418-57079308 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased mean platelet volume and a mild delay in platelet recovery in response to thrombocytopenia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021895 Ensembl Gene Model | MGI Sequence Detail 289013 C57BL/6J ±  kb
transcript ENSMUST00000225949 Ensembl | MGI Sequence Detail 3198 Not Applicable  
polypeptide ENSMUSP00000153396 Ensembl | MGI Sequence Detail 551 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1861 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 82
    cDNA 82

    Microarray probesets 3
Other
Accession IDs
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MGI:1353572, MGI:2442908
References
more
  • Summaries
    All 41
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:241286 Zou S, et al., SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume. PLoS One. 2017;12(5):e0178095

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/13/2017
MGI 6.11
The Jackson Laboratory