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Arhgef3 Gene Detail
Summary
  • Symbol
    Arhgef3
  • Name
    Rho guanine nucleotide exchange factor (GEF) 3
  • Synonyms
    1200004I24Rik, 9830169H03Rik, C76747
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918954
    NCBI Gene: 71704
  • Gene Overview
    MyGene.info: ARHGEF3
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:27114899-27403911 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 16.09 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1861 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918954
protein coding gene Chr14:27114822-27403916 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021091
protein coding gene Chr14:20246010-20418018 (+)
A/J MGP_AJ_G0021039
protein coding gene Chr14:19445014-19619852 (+)
AKR/J MGP_AKRJ_G0021016
protein coding gene Chr14:20506876-20680127 (+)
BALB/cJ MGP_BALBcJ_G0021043
protein coding gene Chr14:19564514-19731000 (+)
C3H/HeJ MGP_C3HHeJ_G0020826
protein coding gene Chr14:20367991-20536555 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021475
protein coding gene Chr14:21087898-21265599 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019038
protein coding gene Chr14:19573494-19741805 (+)
CAST/EiJ MGP_CASTEiJ_G0020351
protein coding gene Chr14:19992880-20168522 (+)
CBA/J MGP_CBAJ_G0020793
protein coding gene Chr14:21928060-22113090 (+)
DBA/2J MGP_DBA2J_G0020915
protein coding gene Chr14:19527076-19694646 (+)
FVB/NJ MGP_FVBNJ_G0020899
protein coding gene Chr14:19490577-19655294 (+)
LP/J MGP_LPJ_G0020984
protein coding gene Chr14:20543183-20725037 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020925
protein coding gene Chr14:21278710-21450200 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021508
protein coding gene Chr14:20265402-20433720 (+)
PWK/PhJ MGP_PWKPhJ_G0020099
protein coding gene Chr14:18939708-19112290 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019923
protein coding gene Chr14:19764932-19929773 (+)
WSB/EiJ MGP_WSBEiJ_G0020406
protein coding gene Chr14:20310788-20491191 (+)



Homology
more
  • Human Ortholog
    ARHGEF3, Rho guanine nucleotide exchange factor 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ARHGEF3, Rho guanine nucleotide exchange factor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GEF3, STA3, XPLN
  • Links
    NCBI Gene ID: 50650
    neXtProt AC: NX_Q9NR81
    UniProt: Q9NR81

  • Chr Location
    3p14.3; chr3:56727418-57079308 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased mean platelet volume and a mild delay in platelet recovery in response to thrombocytopenia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021895 Ensembl Gene Model | MGI Sequence Detail 289013 C57BL/6J ±  kb
transcript ENSMUST00000225949 Ensembl | MGI Sequence Detail 3198 Not Applicable  
polypeptide ENSMUSP00000153396 Ensembl | MGI Sequence Detail 551 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 83
    cDNA 83

    Microarray probesets 3
Other
Accession IDs
less
MGI:1353572, MGI:2442908
References
more
  • Summaries
    All 42
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:241286 Zou S, et al., SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume. PLoS One. 2017;12(5):e0178095

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory