Mcm9
Gene Detail

Symbol Name ID

Mcm9 minichromosome maintenance complex component 9 MGI:1918817

Synonyms

9030408O17Rik, Mcmdc1

Feature Type

protein coding gene

Genetic Map

Chromosome 10

27.21 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr10:53537324-53630439 bp, - strand From NCBI annotation of GRCm38   93116 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:13546  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Mcm9

Human homologs

Human Homolog		MCM9, minichromosome maintenance complex component 9
NCBI Gene ID		254394
neXtProt AC		NX_Q9NXL9
Human Synonyms		C6orf61, dJ329L24.1, dJ329L24.3, MCMDC1
Human Chr (Location)		6q22.31; chr6:119134612-119256327 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(26) : Targeted(2) Gene trapped(24)
 

Mice homozygous for gene trap alleles display germ cell loss with reduced fertility or infertility and increased tumor incidence, particulary of hepatocellular carcinomas.

 
Human Diseases Modeled Using Mouse Mcm9 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	DNA repair, double-strand break repair via homologous recombination, ...
Component	MCM8-MCM9 complex, nucleus
Function	ATP binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (39)    Tissues (10)    Images (30)
Theiler Stages: 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	39

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) cDNA(14)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000058298 (Evidence)
Entrez Gene	71567 (Evidence)
NIA Mouse Gene Index	U031788
EC	3.6.4.12
Consensus CDS Project	CCDS23846.1
International Mouse Knockout Project Status	Mcm9

Sequences

Length	Strain/Species
genomic	71567	NCBI Gene Model | MGI Sequence Detail	93116	C57BL/6J
transcript	NM_027830	RefSeq | MGI Sequence Detail	3873	Not Specified
polypeptide	Q2KHI9	UniProt | EBI | MGI Sequence Detail	1134	Not Applicable

All sequences(29) RefSeq(3) UniProt(3)

Polymorphisms

SNPs(283 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003593	AAA+ ATPase domain
InterPro	IPR001208	Mini-chromosome maintenance, DNA-dependent ATPase
InterPro	IPR012340	Nucleic acid-binding, OB-fold
InterPro	IPR016027	Nucleic acid-binding, OB-fold-like
Protein Ontology	PR:000010251	DNA replication licensing factor MCM9

Graphical View of Protein Domain Structure

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:187623 Lutzmann M, et al., MCM8- and MCM9-Deficient Mice Reveal Gametogenesis Defects and Genome Instability Due to Impaired Homologous Recombination. Mol Cell. 2012 Aug 24;47(4):523-34
All references(42)

Other accession IDs

MGI:2682936, MGI:2685081