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Mcm9
Gene Detail
 Symbol
Name
ID
Mcm9
minichromosome maintenance complex component 9
MGI:1918817
Synonyms 9030408O17Rik, Mcmdc1
Feature Type protein coding gene
Genetic Map
Chromosome 10
27.21 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr10:53537324-53630439 bp, - strand
From NCBI annotation of GRCm38

  93116 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13546  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Mcm9

Human
homologs
Human Homolog MCM9, minichromosome maintenance complex component 9
NCBI Gene ID 254394
neXtProt AC  NX_Q9NXL9
Human Synonyms  C6orf61, dJ329L24.1, dJ329L24.3, MCMDC1
Human Chr (Location)  6q22.31; chr6:118813449-118935162 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(24) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for gene trap alleles display germ cell loss with reduced fertility or infertility and increased tumor incidence, particulary of hepatocellular carcinomas.
 
Human Diseases Modeled Using Mouse Mcm9 (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Mcm9 interacts with 185 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cellular response to DNA damage stimulus, DNA repair, ...
Component MCM8-MCM9 complex, nucleus
Function ATP binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (39)    Tissues (12)    Images (30)
Theiler Stages: 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 39
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000058298 (Evidence)
Entrez Gene71567 (Evidence)
NIA Mouse Gene IndexU031788
EC3.6.4.12
Consensus CDS ProjectCCDS23846.1
International Mouse Knockout Project StatusMcm9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 71567 NCBI Gene Model | MGI Sequence Detail 93116 C57BL/6J ±  kb
transcript NM_027830 RefSeq | MGI Sequence Detail 3873 Not Specified 
polypeptide Q2KHI9 UniProt | EBI | MGI Sequence Detail 1134 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(476 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR001208 Mini-chromosome maintenance, DNA-dependent ATPase
InterPro IPR012340 Nucleic acid-binding, OB-fold
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010251 DNA helicase MCM9
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:203320 Park J, et al., The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination. Mol Cell Biol. 2013 Apr;33(8):1632-44
All references(43)
Disease annotation references (1)
Other
accession IDs
MGI:2682936, MGI:2685081

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory