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Jmjd1c Gene Detail
Summary
  • Symbol
    Jmjd1c
  • Name
    jumonji domain containing 1C
  • Synonyms
    5430433L24Rik, D630035I23Rik, TRIP8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918614
    NCBI Gene: 108829
Location & Maps
more
  • Sequence Map
    Chr10:67096125-67256318 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      160194 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 34.85 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    JMJD1C, jumonji domain containing 1C
  • Vertebrate Orthologs
    10
  • Human Ortholog
    JMJD1C, jumonji domain containing 1C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TRIP8, TRIP-8
  • Links
    NCBI Gene ID: 221037
    neXtProt AC: NX_Q15652

  • Chr Location
    10q21.3; chr10:63167221-63466001 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3129
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: JMJD1C
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    359
  • Chemically induced (other)
    1
  • Gene trapped
    354
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Jmjd1c
  • Incidental Mutations
Mice homozygous for a null allele exhibit an age-dependent male infertility phenotype, characterized by early loss of undifferentiated spermatogonia, and a progressive reduction in testis size/weight and male germ cells, partly due to increased male germ cell apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037955 VEGA Gene Model | MGI Sequence Detail 160194 C57BL/6J ±  kb
transcript OTTMUST00000097831 VEGA | MGI Sequence Detail 8377 Not Applicable  
polypeptide OTTMUSP00000054870 VEGA | MGI Sequence Detail 2531 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    847 from dbSNP Build 142
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000031528 JmjC domain-containing histone demethylation protein 2C
  • EC
  • InterPro Domains
    IPR003347 JmjC domain
Molecular
Reagents
less
  • All nucleic 20
    cDNA 20

    Microarray probesets 3
Other
Accession IDs
less
MGI:2444048
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 20
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:232419 Zhu N, et al., MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C. J Clin Invest. 2016 Mar 1;126(3):997-1011

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory