About   Help   FAQ
Cabyr Gene Detail
Summary
  • Symbol
    Cabyr
  • Name
    calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)
  • Synonyms
    1700016C01Rik, 4933421A18Rik, CBP86, FSP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918382
    NCBI Gene: 71132
  • Gene Overview
    MyGene.info: CABYR
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:12741324-12755146 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 6.77 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    97 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918382
protein coding gene Chr18:12739980-12755151 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024162
protein coding gene Chr18:9946807-9960451 (+)
A/J MGP_AJ_G0024124
protein coding gene Chr18:9746928-9760705 (+)
AKR/J MGP_AKRJ_G0024091
protein coding gene Chr18:10045547-10064043 (+)
BALB/cJ MGP_BALBcJ_G0024123
protein coding gene Chr18:9700578-9714976 (+)
C3H/HeJ MGP_C3HHeJ_G0023890
protein coding gene Chr18:9932936-9946709 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024568
protein coding gene Chr18:10432681-10452738 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022008
protein coding gene Chr18:9318383-9332251 (+)
CAST/EiJ MGP_CASTEiJ_G0023367
protein coding gene Chr18:9810586-9824204 (+)
CBA/J MGP_CBAJ_G0023862
protein coding gene Chr18:10583572-10599946 (+)
DBA/2J MGP_DBA2J_G0023991
protein coding gene Chr18:9587297-9601828 (+)
FVB/NJ MGP_FVBNJ_G0023956
protein coding gene Chr18:9462127-9476108 (+)
LP/J MGP_LPJ_G0024074
protein coding gene Chr18:10023704-10038717 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023985
protein coding gene Chr18:10733148-10749077 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024614
protein coding gene Chr18:9818353-9832897 (+)
PWK/PhJ MGP_PWKPhJ_G0023113
protein coding gene Chr18:9657894-9671670 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022922
protein coding gene Chr18:10077294-10090614 (+)
WSB/EiJ MGP_WSBEiJ_G0023433
protein coding gene Chr18:9811938-9825795 (+)



Homology
more
  • Human Ortholog
    CABYR, calcium binding tyrosine phosphorylation regulated
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CABYR, calcium binding tyrosine phosphorylation regulated
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CABYRa, CABYRc, CABYRc/d, CABYRe, CBP86, CT88, FSP2, FSP-2
  • Links
    NCBI Gene ID: 26256
    neXtProt AC: NX_O75952
    UniProt: O75952

  • Chr Location
    18q11.2; chr18:24138956-24161600 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Cabyr mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous knockout affects sperm flagellum morphology, resulting in reduced sperm motility. These mutant males are subfertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024430 Ensembl Gene Model | MGI Sequence Detail 13823 C57BL/6J ±  kb
transcript ENSMUST00000115857 Ensembl | MGI Sequence Detail 1557 Not Applicable  
polypeptide ENSMUSP00000111523 Ensembl | MGI Sequence Detail 453 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000004939 calcium-binding tyrosine phosphorylation-regulated protein
  • InterPro Domains
    IPR038848 Calcium-binding tyrosine phosphorylation-regulated protein
    IPR003117 cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 6
Other
Accession IDs
less
MGI:1919109
References
more
  • Summaries
    All 26
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 5
    Phenotypes 2
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:247126 Young SA, et al., CABYR is essential for fibrous sheath integrity and progressive motility in mouse spermatozoa. J Cell Sci. 2016 Dec 01;129(23):4379-4387

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory