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Phenotypes Associated with This Genotype
Genotype
MGI:6152755
Allelic
Composition
Cabyrem1Osb/Cabyrem1Osb
Genetic
Background
involves: C57BL/6NJcl * DBA/2NJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cabyrem1Osb mutation (2 available); any Cabyr mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• in mature caudal epididymal spermatozoa
• occasional extra doublet microtubules located outside fibrous sheath
• normal midpiece morphology
• disorganized fibrous sheath in mature caudal epididymal spermatozoa with unwound fibers and increased cytosolic space between axoneme and plasma membrane
• occasional extra doublet microtubules located outside fibrous sheath
• in mature caudal epididymal spermatozoa
• disorganized axonemal structure of proximal and distal regions of principal piece with more or fewer doublet microtubules than normal
• fibrous sheath transverse ribs preferentially disrupted or expanded and of abnormal morphology
• disorganized fibrous sheath with unwound fibers and increased cytosolic space between axoneme and plasma membrane
• abnormal morphology of fibrous sheath adjacent to doublet microtubules 3 and 8
• abnormal morphology of ribs in medial section of longitudinally lying flagella
• significantly higher frequency of vertically aligned ribs in lateral sections of longitudinally lying flagella
• normal morphology of longitudinal columns in medial section of longitudinally lying flagella
• significantly lower occurrence of hyperactivation after 2 h incubation
• only one pup born from 17 homozygous mutant male to wild-type female matings during 3 months
• inability of sperm to fertilize oocytes (cumulus-intact or cumulus-free) in vitro
• inability of sperm to penetrate zona pellucida of oocytes in vitro
• normal sperm fusion with oocytes free of zona pellucida in vitro
• normal binding of sperm to zona pellucida of oocytes in vitro
• normal acrosome reaction of sperm cells in vitro
• significantly lower average path velocity (VAP), straight line velocity (VSL) and curvilinear velocity (VCL) at both 10 min and 120 min of incubation
• decreased percentage motile cells in capacitating or non-capacitating medium
• in capacitating or non-capacitating medium
• only one pup born from 17 homozygous mutant male to wild-type female matings during 3 months

cellular
• in mature caudal epididymal spermatozoa
• occasional extra doublet microtubules located outside fibrous sheath
• normal midpiece morphology
• disorganized fibrous sheath in mature caudal epididymal spermatozoa with unwound fibers and increased cytosolic space between axoneme and plasma membrane
• occasional extra doublet microtubules located outside fibrous sheath
• in mature caudal epididymal spermatozoa
• disorganized axonemal structure of proximal and distal regions of principal piece with more or fewer doublet microtubules than normal
• fibrous sheath transverse ribs preferentially disrupted or expanded and of abnormal morphology
• disorganized fibrous sheath with unwound fibers and increased cytosolic space between axoneme and plasma membrane
• abnormal morphology of fibrous sheath adjacent to doublet microtubules 3 and 8
• abnormal morphology of ribs in medial section of longitudinally lying flagella
• significantly higher frequency of vertically aligned ribs in lateral sections of longitudinally lying flagella
• normal morphology of longitudinal columns in medial section of longitudinally lying flagella
• significantly lower average path velocity (VAP), straight line velocity (VSL) and curvilinear velocity (VCL) at both 10 min and 120 min of incubation
• decreased percentage motile cells in capacitating or non-capacitating medium
• in capacitating or non-capacitating medium

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
male infertility DOID:12336 J:247126


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory